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Virological and Cellular Roles of the Transcriptional Coactivator LEDGF/p75

Chapter
First Online:
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 339)

Abstract

The chromatin-associated cellular proteins LEDGF/p75 and LEDGF/p52 have been implicated in transcriptional regulation, cell survival and autoimmunity. LEDGF/p75 also appears to act as a chromatin-docking factor or receptor for HIV-1 and other lentiviruses and to play a role in leukemogenesis. For both the viral and cellular roles of this protein, a key feature is its ability to act as a molecular adaptor and tether proteins to the chromatin fiber. This chapter reviews the emerging roles of LEDGF/p75 and LEDGF/p52 in diverse cellular processes and disease states.

Keywords

Nuclear Localization Signal Feline Immunodeficiency Virus Equine Infectious Anemia Virus Strand Transfer Chromatin Binding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Notes

Acknowledgements

We are grateful for support from N.I.H. grants 1SC2GM082301 to M. L. and AI77344 to E.M.P. We thank P. Spearman for editorial advice, and patience.

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© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  1. 1.Department of Molecular Medicine, Department of Molecular Medicine and Division of Infectious DiseasesMayo Clinic College of MedicineRochesterUSA
  2. 2.Biological Sciences DepartmentUniversity of TexasEl PasoUSA

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