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The Roles of Tetraspanins in HIV-1 Replication

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HIV Interactions with Host Cell Proteins

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 339))

Abstract

Tetraspanins are small integral membrane proteins that are known to control a variety of cellular processes, including signaling, migration and cell–cell fusion. Research over the past few years established that they are also regulators of various steps in the HIV-1 replication cycle, but the mechanisms through which these proteins either enhance or repress virus spread remain largely unknown.

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Acknowledgements

I thank the current members of my group, Dimitry Krementsov, Marie Lambelé, Nate Roy and Jia Weng, for critical reading of the manuscript. Work in our laboratory is supported by the NIH and by UVM’s College of Medicine.

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  1. Department of Microbiology and Molecular Genetics, College of Medicine and CALS, University of Vermont, 318 Stafford Hall, 95 Carrigan Drive, Burlington, VT, 05405-0084, USA

    Markus Thali

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Correspondence to Markus Thali .

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Editors and Affiliations

  1. School of Medicine, Dept. Pediatrics, Emory University, Uppergate Drive NE., 2015, Atlanta, 30322, Georgia, USA

    Paul Spearman

  2. HIV Drug Resistance Program, National Cancer Institute-Frederick, Frederick, Maryland, USA

    Eric O. Freed

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Thali, M. (2009). The Roles of Tetraspanins in HIV-1 Replication. In: Spearman, P., Freed, E. (eds) HIV Interactions with Host Cell Proteins. Current Topics in Microbiology and Immunology, vol 339. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02175-6_5

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