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Contraception Targets in Mammalian Ovarian Development

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Fertility Control

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 198))

Abstract

In the human ovary, early in pre-natal life, oocytes are surrounded by pre-granulosa follicular cells to form primordial follicles. These primordial oocytes remain dormant, often for decades, until recruited into the growing pool throughout a woman’s adult reproductive years. Activation of follicle growth and subsequent development of growing oocytes in pre-antral follicles are major biological checkpoints that determine an individual females reproductive potential. In the past decade, great strides have been made in the elucidation of the molecular and cellular mechanisms underpinning maintenance of the quiescent primordial follicle pool and initiation and development of follicle growth. Gaining an in-depth knowledge of the intracellular signalling systems that control oocyte preservation and follicle activation has significant implications for improving female reproductive productivity and alleviating infertility. It also has application in domestic animal husbandry, feral animal population control and contraception in women.

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Acknowledgements

The authors gratefully acknowledge the financial assistance to EAM by the Australian Research Council, National Health and Medical Research Council, Hunter Medical Research Institute and the Newcastle Permanent Building Society Charitable Trust. APS is the recipient of an Australian Postgraduate Award PhD scholarship.

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Authors and Affiliations

  1. Reproductive Science Group, School of Environmental & Life Sciences, University of Newcastle, Callaghan, NSW, 2308, Australia

    Eileen A. McLaughlin & Alexander P. Sobinoff

  2. ARC Centre of Excellence in Biotechnology & Development, University of Newcastle, Callaghan, NSW, 2308, Australia

    Eileen A. McLaughlin

Authors
  1. Eileen A. McLaughlin
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  2. Alexander P. Sobinoff
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Correspondence to Eileen A. McLaughlin .

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Editors and Affiliations

  1. , Women's Health Care Research, Bayer Schering Pharma AG, Berlin, 13342, Berlin, Germany

    Ursula-F. Habenicht

  2. ARC Centre of Excellence in, Biotechnology & Development, University of Newcastle, Callaghan, 2308, New South Wales, Australia

    R. John Aitken

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McLaughlin, E.A., Sobinoff, A.P. (2010). Contraception Targets in Mammalian Ovarian Development. In: Habenicht, UF., Aitken, R. (eds) Fertility Control. Handbook of Experimental Pharmacology, vol 198. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02062-9_4

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