Integrative Approach for Combining TNFα-NFκB Mathematical Model to a Protein Interaction Connectivity Map

  • Mahesh Visvanathan
  • Bernhard Pfeifer
  • Christian Baumgartner
  • Bernhard Tilg
  • Gerald Henry Lushington
Part of the Lecture Notes in Computer Science book series (LNCS, volume 5542)


We have investigated different mathematical models for signaling pathways and built a new pathway model for TNFα-NFκB signaling using an integrative analytical approach. This integrative approach consists of a knowledgebase, model designing/visualization and simulation environments. In particular, our new TNFα-NFκB signaling pathway model was developed based on literature studies and the use of ordinary differential equations and a detailed protein-protein interaction connectivity map within this approach. Using the most detailed mathematical model as a base model, three new relevant proteins – TRAF1, FLIP, and MEKK3 – were identified and included in our new model. Our results show that this integrative approach offers the most detailed and consistent mathematical description for TNFα-NFκB signaling and further increases the understanding of TNFα-NFκB signaling pathway.


TNFα mediated NF-κB signaling pathway protein-protein interaction and mathematical model 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Mahesh Visvanathan
    • 1
  • Bernhard Pfeifer
    • 2
  • Christian Baumgartner
    • 2
  • Bernhard Tilg
    • 2
  • Gerald Henry Lushington
    • 1
  1. 1.Bioinformatics Core FacilityUniversity of KansasLawrenceUSA
  2. 2.Medical Informatics and Technology (UMIT) Hall in TyrolUniversity for Health SciencesAustria

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