Zusammenfassung
Der Begriff Atherothrombose beschreibt die Kombination aus akuten und chronischen Ereignissen in erkrankten arteriellen Gefäßen und stellt derzeit v. a. in den westlichen Ländern die hauptsächliche Ursache für Morbidität und Mortalität dar. Frühes Erkennen und Risikostratifizierung sind nach wie vor ein wichtiger Bestandteil der Prävention der Atherosklerose und ihrer Komplikationen. Neben klassischen Risikofaktoren sind in den letzten Jahren verschiedene Messparameter erarbeitet worden, die einen gesicherten oder möglichen prognostischen Faktor für Aspekte der Atherothrombose darstellen. Eine weitere wichtige Ursache für Thromboembolien im arteriellen System, v. a. bei jungen Patienten, stellt ein persistierendes Foramen ovale (PFO) dar, das zu einem Rechts-links-Shunt und damit zum übertreten von thrombotischem Material in den aortalen Kreislauf führen kann.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
Literatur
Bhatt DL, Steg PG, Ohman EM et al. (2006) International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis. JAMA 295: 180–9.
Bigalke B, Lindemann S, Ehlers R et al. (2006) Expression of platelet collagen receptor glycoprotein VI is associated with acute coronary syndrome. Eur Heart J 27: 2165–9
Blankenberg S, McQueen MJ, Smieja M et al. (2006) Comparative impact of multiple biomarkers and N-Terminal pro-brain natriuretic peptide in the context of conventional risk factors for the prediction of recurrent cardiovascular events in the Heart Outcomes Prevention Evaluation (HOPE) Study. Circulation 114: 201–8
Bogousslavsky J, Garazi S, Jeanrenaud X et al. (1996) Stroke recurrence in patients with patent foramen ovale: the Lausanne Study. Lausanne Stroke with Paradoxal Embolism Study Group. Neurology 46: 1301–5
Cujec B, Mainra R, Johnson DH (1999) Prevention of recurrent cerebral ischemic events in patients with patent foramen ovale and cryptogenic strokes or transient ischemic attacks. Can J Cardiol 15: 57–64
Folsom AR, Chambless LE, Ballantyne CM et al. (2006) An assessment of incremental coronary risk prediction using C-reactive protein and other novel risk markers: the atherosclerosis risk in communities study. Arch Intern Med 166: 1368–73
Gawaz M, Langer H, May AE (2005) Platelets in inflammation and atherogenesis. J Clin Invest 115: 3378–84
Healy AM, Pickard MD, Pradhan AD et al. (2006) Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular events. Circulation 113: 2278–84
Homma S, Sacco RL, Di Tullio MR et al. (2002) Effect of medical treatment in stroke patients with patent foramen ovale: patent foramen ovale in Cryptogenic Stroke Study. Circulation 105: 2625–31
Khairy P, O’Donnell CP, Landzberg MJ (2003) Transcatheter closure versus medical therapy of patent foramen ovale and presumed paradoxical thromboemboli: a systematic review. Ann Intern Med 139: 753–60
Kizer JR, Devereux RB (2005) Clinical practice. Patent foramen ovale in young adults with unexplained stroke. N Engl J Med 353: 2361–72
Mattace-Raso FU, van der Cammen TJ, Hofman A et al. (2006) Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation 113: 657–63
O’Hare AM, Katz R, Shlipak MG et al. (2006) Mortality and cardiovascular risk across the ankle-arm index spectrum: results from the Cardiovascular Health Study. Circulation 113: 388–93
Orgera MA, O’Malley PG, Taylor AJ (2001) Secondary prevention of cerebral ischemia in patent foramen ovale: systematic review and meta-analysis. South Med J 94: 699–703
Redgrave JN, Lovett JK, Gallagher PJ et al. (2006) Histological assessment of 526 symptomatic carotid plaques in relation to the nature and timing of ischemic symptoms: the Oxford plaque study. Circulation 113: 2320–8
Ruggeri ZM (2002) Platelets in atherothrombosis. Nat Med 8: 1227–34
Sanz J, Moreno PR, Fuster V (2007) The year in atherothrombosis. J Am Coll Cardiol 49: 1740–9
Sattar N, Wannamethee G, Sarwar N et al. (2006) Adiponectin and coronary heart disease: a prospective study and meta-analysis. Circulation 114: 623–9
Schnabel R, Lubos E, Rupprecht HJ et al. (2006) B-type natriuretic peptide and the risk of cardiovascular events and death in patients with stable angina: results from the AtheroGene study. J Am Coll Cardiol 47: 552–8
Smith A, Patterson C, Yarnell J et al. (2005) Which hemostatic markers add to the predictive value of conventional risk factors for coronary heart disease and ischemic stroke? The Caerphilly Study. Circulation 112: 3080–7
Werner N, Kosiol S, Schiegl T et al. (2005) Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med 353: 999–1007
Wilson PW, D’Agostino RB, Levy D et al. (1998) Prediction of coronary heart disease using risk factor categories. Circulation 97: 1837–47
Yusuf S, Hawken S, Ounpuu S et al. (2005) Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a casecontrol study. Lancet 366: 1640–9
Literatur
Alessi MC, Juhan-Vague I (2006) PAI-1 and the metabolic syndrome — Links, causes, and consequences. Arterioscler Thromb Vascular Biol 26(10): 2200–7
Bonaa KH, Njolstad I, Ueland PM, Schirmer H, Tverdal A, Steigen T et al. (2006) Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Eng J Med 354(15): 1578–88
Brey RL (2004) Management of the neurological manifestations of APS — what do the trials tell us? Thrombosis Research 114(5–6): 489–99
Cervera R, Khamashta MA, Font J, Sebastiani GD, Gil A, Lavilla P et al. (2003) Morbidity and mortality in systemic lupus erythematosus during a 10-year period — A comparison of early and late manifestations in a cohort of 1,000 patients. Medicine 82(5): 299–308
Cervera R, Piette JC, Font J, Khamashta MA, Cervera R, Piette JC et al. (2002) Antiphospholipid syndrome — Clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis and Rheumatism 46(4): 1019–27
Chen YQ, Su M, Walia RR, Hao Q, Covington JW, Vaughan DE (1998) Sp1 sites mediate activation of the plasminogen activator inhibitor-1 promoter by glucose in vascular smooth muscle cells. J Biol Chem 273(14): 8225–31
Clarke R, Collins R, Lewington S, Donald A, Alfthan G, Tuomilehto J et al. (2002) Homocysteine and risk of ischemic heart disease and stroke — A meta-analysis. Jama 288(16): 2015–22
Colman RW (2006) Are hemostasis and thrombosis two sides of the same coin? J Exper Med 203(3): 493–5
Cushman M, Lemaitre RN, Kuller LH, Psaty BM, Macy EM, Sharrett AR et al. (1999) Fibrinolytic activation markers predict myocardial infarction in the elderly — The cardiovascular health study. Arterioscler Thromb Vascular Biol 19(3): 493–8
Dawson S, Hamsten A, Wiman B, Henney A, Humphries S (1991) Genetic-Variation at the Plasminogen-Activator Inhibitor-1 Locus Is Associated with Altered Levels of Plasma Plasminogen-Activator Inhibitor-1 Activity. Arteriosclerosis and Thrombosis 11(1): 183–90
De Groot PG, Derksen RHMW (2005) The antiphospholipid syndrome: clinical characteristics, laboratory features and pathogenesis. Current Opinion in Infectious Diseases 18(3): 205–10
Eldibany MM, Caprini JA (2007) Hyperhomocysteinemia and thrombosis — An overview. Archives of Pathology & Laboratory Medicine 131(6): 872–84
Endler G, Marsik C, Jilma B, Schickbauer T, Quehenberger P, Mannhalter C (2007) Evidence of a U-shaped association between factor XII activity and overall survival. J Thrombosis Haemostasis 5(6): 1143–8
Eriksson P, Kallin B, Vanthooft FM, Bavenholm P, Hamsten A (1995) Allele-Specific Increase in Basal Transcription of the Plasminogen-Activator Inhibitor-1 Gene Is Associated with Myocardial-Infarction. Proceedings of the National Academy of Sciences of the United States of America 14; 92(6): 1851–5
Feinbloom D, Bauer KA (2005) Assessment of hemostatic risk factors in predicting arterial thrombotic events. Arterioscler Thromb Vascular Biol 25(10): 2043–53
Festa A, D’Agostino R, Tracy RP, Haffner SM (2002) Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes — The insulin resistance atherosclerosis study. Diabetes 51(4): 1131–7
Gailani D, Renne T (2007) Intrinsic pathway of coagulation and arterial thrombosis. Arterioscler Thromb Vascular Biol 27(12): 2507–13
Galli M (2003) Antiphospholipid syndrome: Association between laboratory tests and clinical practice. Pathophysiology of Haemostasis and Thrombosis 33(5–6): 249–55
Galli M (2005) Pathogenesis of antiphospholipid syndrome. Thrombosis Research 115: 103–7
Galli M, Luciani D, Bertolini G, Barbui T (2003) Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature. Blood 101(5): 1827–32
Giannakopoulos B, Passam F, Rahgozar S, Krilis SA (2007) Current concepts on the pathogenesis of the antiphospholipid syndrome. Blood 109(2): 422–30
Ginsburg D (2005) Genetic Risk Factors for Arterial Thrombosis and Inflammation. Hematology p 442–4
Girolami A, Randi ML, Gavasso S, Lombardi AM, Spiezia F (2004) The occasional venous thromboses seen in patients with severe (homozygous) FXII deficiency are probably due to associated risk factors: A study of prevalence in 21 patients and review of the literature. J Thrombosis Thrombolysis 17(2): 139–43
Govers-Riemslag JWP, Smid M, Cooper JA, Bauer KA, Rosenberg RD, Hack CE et al. (2007) The plasma kallikrein-kinin system and risk of cardiovascular disease in men. J Thrombosis Haemostasis 5(9): 1896–903
Green D (2003) Thrombophilia and Stroke. Topics in Stroke Rehabilitation 10(3): 21–33
Halleux CM, Declerck PJ, Tran SL, Detry R, Brichard SM (1999) Hormonal control of plasminogen activator inhibitor-1 gene expression and production in human adipose tissue: Stimulation by glucocorticoids and inhibition by catecholamines. J Clin Endocrinol Metabolism 84(11): 4097–105
Healy AM, Gelehrter TD (1994) Induction of Plasminogen-Activator Inhibitor-1 in Hepg2 Human Hepatoma-Cells by Mediators of the Acute-Phase Response. J Biol Chem 269(29): 19095–100
Heymans S, Luttun A, Nuyens D, Theilmeier G, Creemers E, Moons L et al. (1999) Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure. Nature Medicine 5(10):1135–42
Iacoviello L, Burzotta F, Di Castelnuovo A, Zito F, Marchioli R, Donati MB (1998). The 4G/5G polymorphism of PAI-1 promoter gene and the risk of myocardial infarction: A meta-analysis. Thrombosis and Haemostasis 80(6): 1029–30
Johansson L, Jansson JH, Boman K, Nilsson TK, Stegmayr B, Hallmans G (2000) Tissue plasminogen activator, plasminogen activator inhibitor-1, and tissue plasminogen activator/plasminogen activator inhibitor-1 complex as risk factors for the development of a first stroke. Stroke 31(1): 26–32
Kohler HP, Grant PJ (2000) Mechanisms of disease: Plasminogen-activator inhibitor type 1 and coronary artery disease. N Eng J Med 342(24): 1792–801
Koster T, Rosendaal FR, Briet E, Vandenbroucke JP (1994) John Hageman’s factor and deep-Vein thrombosis: Leiden Thrombophilia Study. Brit J Haematol 87(2): 422–4
Ladenvall P, Johansson L, Jansson JH, Jern S, Nilsson TK, Tjarnlund A et al. (2002) Tissue-type plasminogen activator-7,351 C/T enhancer polymorphism is associated with a first myocardial infarction. Thrombosis and Haemostasis 87(1): 105–9
Lane DA, Grant PJ (2000) Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease. Blood 95(5): 1517–32
Levine JS, Branch DW, Rauch J (2002) Medical progress: The antiphospholipid syndrome. N Eng J Med 346(10): 752–63
Libby P, Theroux P (2005) Pathophysiology of coronary artery disease. Circulation 111(25): 3481–8
Lonn E, Yusuf S, Arnold MJ, Sheridan P, Pogue J, Micks M et al. (2006) Homocysteine lowering with folic acid and B vitamins in vascular disease. N Eng J Med 354(15): 1567–77
Loscalzo J (2006) Homocysteine trials — Clear outcomes for complex reasons. N Eng J Med 354(15): 1629–32
Lundblad D, Dinesen B, Rautio A, Roder ME, Eliasson M (2005) Low level of tissue plasminogen activator activity in non-diabetic patients with a first myocardial infarction. J Intern Med 258(1): 13–20
Mammen EF (1999) Sticky platelet syndrome. Seminars in Thrombosis and Hemostasis 25(4): 361–5
Mannucci PM, Bernardinelli L, Foco L, Galli M, Ribichini F, Tubaro M et al. (2005) Tissue plasminogen activator antigen is strongly associated with myocardial infarction in young women. J Thrombosis Haemostasis 3(2): 280–6
Mannucci PM, Merlini PA, Ardissino D, Barzuini C, Bernardi F, Bernardinelli L et al. (2003) No evidence of association between prothrombotic gene Polymorphisms and the development of acute myocardial infarction at a young age. Circulation 107(8): 1117–22
Martinelli I (2005) von Willebrand factor and factor VIII as risk factors for arterial and venous thrombosis. Seminars in Hematology 42(1): 49–55
Melchor JP, Strickland S (2005) Tissue plasminogen activator in central nervous system physiology and pathology. Thrombosis and Haemostasis 93(4): 655–60
Meltzer ME, Doggen CJM, De Groot PG, Rosendaal FR, Lisman T (2007) Fibrinolysis and the risk of venous and arterial thrombosis. Current Opinion in Hematology 14(3): 242–8
Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R et al. (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thrombosis Haemostasis 4(2): 295–306
Ortel TL (2005) Thrombosis and the Antiphospholipid Syndrome. Hematology p 462–8
Reitsma PH (2004) Is hypercoagulability an issue in arterial thrombosis? No. J Thrombosis Haemostasis 2(5): 692–4
Ross R (1999) Mechanisms of disease — Atherosclerosis — An inflammatory disease. N Eng J Med 340(2): 115–26
Salomon O, Steinberg DM, Dardik R, Rosenberg N, Zivelin A, Tamarin I et al. (2003) Inherited factor XI deficiency confers no protection against acute myocardial infarction. J Haemostasis 1(4): 658–61
Schousboe I (2008) Pharmacological regulation of factor XII activation may be a new target to control pathological coagulation. Biological Pharmacology 75(5): 1007–1013
Smith A, Patterson C, Yarnell J, Rumley A, Ben-Shlomo Y, Lowe G (2005) Which hemostatic markers add to the predictive value of conventional risk factors for coronary heart disease and ischemic stroke? The Caerphilly Study. Circulation 112(20): 3080–7
Smith SA, Mutch NJ, Baskar D, Rohloff P, Docampo R, Morrissey JH (2006) Polyphosphate modulates blood coagulation and fibrinolysis. Proceedings of the National Academy of Sciences of the United States of America 103(4): 903–8
Takazoe K, Ogawa H, Yasue H, Sakamoto T, Soejima H, Miyao Y et al. (2001) Increased plasminogen activator inhibitor activity and diabetes predict subsequent coronary events in patients with angina pectoris. Annals of Medicine 33(3): 206–12
Thogersen AM, Soderberg S, Jansson JH, Dahlen G, Boman K, Nilsson TK et al. (2004) Interactions between fibrinolysis, lipoproteins and leptin related to a first myocardial infarction. Europ J Cardiovasc Prevention Rehabil 11(1): 33–40
Toole JF, Malinow MR, Chambless LE, Spence JD, Pettigrew LC, Howard VJ et al. (2004) Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death — The Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. Jama 291(5): 565–75
Vaughan DE, Lazos SA, Tong K (1995) Angiotensin-Ii Regulates the Expression of Plasminogen-Activator Inhibitor-1 in Cultured Endothelial-Cells — A Potential Link Between the Renin-Angiotensin System and Thrombosis. J Clin Invest 95(3): 995–1001
Voetsch B, Loscalzo J (2004) Genetic determinants of arterial thrombosis. Arterioscler Thromb Vascular Biol 24(2): 216–29
Wald DS, Law M, Morris JK (2002) Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. Brit Med J 325(7374): 1202–1206K
Wiman B, Andersson T, Hallqvist J, Reuterwall C, Ahlbom A, deFaire U (2000) Plasma levels of tissue plasminogen activator/plasminogen activator inhibitor-1 complex and von willebrand factor are significant risk markers for recurrent myocardial infarction in the Stockholm Heart Epidemiology Program (SHEEP) study. Arterioscler Thromb Vascular Biol 20(8): 2019–23
Zeerleder S, Schloesser M, Redondo M, Wuillemin WA, Engel W, Furlan M et al. (1999) Reevaluation of the incidence of thromboembolic complications in congenital factor XII deficiency — A study on 73 subjects from 14 Swiss families. Thrombosis and Haemostasis 82(4): 1240–6
Zorio E, Castello R, Falco C, Espana F, Osa A, Almenar L et al. (2003) Thrombin-activatable fibrinolysis inhibitor in young patients with myocardial infarction and its relationship with the fibrinolytic function and the protein C system. Brit J Haematol 122(6): 958–65
Zotz RB, Klein M, Dauben HP, Moser C, Gams E, Scharf RE (2000) Prospective analysis after coronary-artery bypass grafting: platelet GP IIIa polymorphism (HPA-1b/PIA2) is a risk factor for bypass occlusion, myocardial infarction, and death. Thromb Haemost 83(3): 404–7
Zotz RB, Scharf RE (2002) Platelet Receptor Polymorphisms and their Role in Cardiovascular Disease. Laboratoriumsmedizin/J Lab Med 26(11–12): 584–93
Zotz RB, Winkelmann BR, Muller C, Boehm BO, Marz W, Scharf RE (2005) Association of polymorphisms of platelet membrane integrins alpha IIb beta 3 (HPA-1b/Pl(A2)) and alpha(2)beta(1) (alpha(2)807TT) with premature myocardial infarction. J Thrombosis Haemostasis 3(7): 1522–9
Literatur
Antithrombotic Trialists’Collaboration (2002) Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 324: 71–86
Arca M, Gaspardone A (2007) Atorvastatin efficacy in the primary and secondary prevention of cardiovascular events. Drugs 67,Suppl 1: 29–42
Bhatt DL, Fox KAA, Werner ChB et al. (2006) Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med 354: 1706–1717
Diener HC, Sacco RL, Yusuf S et al; Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) study group (2008) Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a doubleblind, active and placebo-controlled study. Lancet Neurol 7: 875–884. Erratum in: Lancet Neurol 2008;7(11): 985
CARS-Investigators (1997) Randomised double-blind trial of fixed lowdose warfarin with aspirin after myocardial infarction. Lancet 350: 389–396
Catella-Lawson F, Reilly MP, Kapoor SC et al. (2001) Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med 345: 1809–1817
CURE-Trial Investigators (2001) Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 345: 494–502
Diener HC, Cunha L, Forbes C et al. (1996) European Stroke Prevention Study 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci 143: 1–13
Diener HC, Bogousslavsky J, Brass LM et al. on behalf of the MATCH investigators (2004) Aspirin and clopidogrel compared with clopidogrel alone after recent ischemic stroke in high-risk patients (MATCH): randomized, double-blind, placebo-controlled trial. Lancet 364: 331–337
(The) ESPRIT-Study Group (2006) Aspirin plus dipyridamole versus aspirin alone after cerebral ischemia of arterial origin (ESPRIT): randomised controlled trial. Lancet 367: 1665–1673
Frilling B, Schiele R, Gitt AK et al. (2001) Characterization and clinical course of patients not receiving aspirin for acute myocardial infarction: results from the MITRA and MIR studies. Am Heart J 141: 200–205
Gawaz M (2004) Role of platelets in coronary thrombosis and reperfusion of ischemic myocardium. Cardiovasc Res 61: 498–511
Geisler T, Graß D, Bigalke B et al. (2008) The Residual Platelet Aggregation after Deployment of Intracoronary Stent (PREDICT) score. J Thromb Haemost 6: 54–61
Gent M and CAPRIE Steering Committee (1996) A randomised, blinded trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 348: 1329–1339
Helin-Salminvaara A, Virtanen A, Vesalainen R et al. (2006) NSAID use and the risk of hospitalization for first myocardial infarction in the general population: a nationwide case-control study from Finland. Eur Heart J 27: 1657–1663
Hennekens CH, Sacks FM, Tonkin A et al. (2004) Additive benefits of pravastatin and aspirin to decrease risks of cardiovascular disease: randomized and observational comparisons of secondary prevention trials and their meta-analyses. Arch Int Med 164: 40–44
Hohlfeld T, Zimmermann N, Weber A-A et al. (2008) Pyrazolinone analgesics prevent the antiplatelet effect of aspirin and preserve human platelet thromboxane synthesis. J Thromb Haemost 6: 166–173
ISIS-2 (1988) Randomized trial of intravenous streptokinase, oral aspirin, both or neither among 17,187 cases of suspected acute myocardial infarction. Lancet 2: 349–360
Juul-Möller S, Edvardsson N, Jahnmatz B et al. () For the Swedish Angina Pectoris Aspirin Trial (SAPAT) Group. Double-blind trial of aspirin in primary prevention of myocardial infarction in patients with chronic stable angina pectoris. Lancet 1992 340: 1421–1425
Kearney PM, Baigent C, Godwin J et al. (2006) Do selective cyclooxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials. BMJ 332: 1302–1308
Labinaz M, Ho C, Banerjee S et al. (2007) Meta-analysis of clinical efficacy and bleeding risk with intravenous glycoprotein IIb/IIIa antagonists for percutaneous coronary intervention. Can J Cardiol 23: 963–970
Laufs U, Liao JK (2000) Targeting Rho in cardiovascular disease. Circ Res 87: 526–528
Massberg S, Schulz C, Gawaz M (2003) Role of platelets in the pathophysiology of acute coronary syndrome. Sem Vasc Med 3: 147–162
Mac Donald TM, Wei L (2003) Effect of ibuprofen on cardioprotective effect of aspirin. Lancet 361: 573–574
(The) Medical Research Council’s General Practice Research Framework (1998) Thrombosis prevention trial: randomised trial of low-intensity oral anticoagulation with warfarin and low-dose aspirin in the primary prevention of ischaemic heart disease in men at increased risk. Lancet 351: 233–241
McAlister FA, Ghali WA, Gong Y et al. (2006) Aspirin use and outcomes in a community-based cohort of 7352 patients discharged after first hospitalization for heart failure. Circulation 113: 2572–2578
O’Regan C, Wu P, Arora P et al. (2008) Statin therapy in stroke prevention: a metaanalysis involving 121,000 patients. Am J Med 121: 24–33
Patrono C, Coller B, Dalen JE et al. (2001) Platelet-active drugs. The relationship among dose, effectiveness, and side effects. Chest 119: 39S–63S
Sacks FM, Pfeffer MA, Moye LA et al. for the Cholesterol and Recurrent Events Trial Investigators (CARE) (1996) The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N Engl J Med 335: 1001–1009
Schrör K. Mehta P, Mehta JL (2005) Cardiovascular risk of selective cyclooxygenase-2-inhibitors. J Cardiovasc Pharmacol Ther 10: 95–101
Siller-Matula J, Schrör K, Wojta J, Huber K (2007) Thienopyridines in cardiovascular disease: Focus on clopidogrel resistance. Thromb Haemost 97: 385–393
Spencer FA, Santopinto JJ, Gore JM, Goldberg RJ et al. (2002) Impact of aspirin on presentation and hospital outcomes in patients with acute coronary syndromes (The Global Registry of acute Coronary Events [GRACE]). Am J Cardiol 90: 1056–1061
Steering Committee of the Physicians’ Health Study Research Group (1989) Final report on the aspirin component of the ongoing Physicians’ Health Study. N Engl J Med 321: 129–13
Stys T, Lawson WE, Smaldone GC, Stys A (2000) Does aspirin attenuate the beneficial effects of angiotensin-converting enzyme inhibition in heart failure? Arch Int Med 160: 1409–1413
Literatur
Adams HP, del Zoppo G, Alberts MJ et al. (2007) Guidelines for the early management of adults with ischemic stroke. Stroke 38: 1655–1711
Adams RJ, Albers G, Alberts MJ et al. (2008) Update to the AHA/ASA Recommendations for the prevention of stroke in patients with stroke and transient ischemic attacks. Stroke 39: 1647–1652
Albers G et al. (2006) Guidelines for the prevention of stroke in patients with ischemic stroke or transient ischemic attacks. Circulation 113: e409–e449
Amarenco P, Bogousslavsky J, Callahan A 3rd et al. (2006) High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med 355: 549–559
Amarenco P, Labreuche J, Lavallee P, Touboul PJ (2004) Statins in stroke prevention and carotid atherosclerosis: systematic review and upto-date meta-analysis. Stroke 35: 2902–2909
Bhatt DL, Fox KAA, Hacke W (2006) Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med 354: 1706–1717
Colhoun HM, Betteridge DJ, Durrington PN et al. (2004) Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet 364: 685–696
Collins R, Peto R, MacMahon S et al. (1990) Blood pressure, stroke, and coronary heart disease. Part 2, Short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context. Lancet 335: 827–838
Connolly S, Pogue J, Hart R et al. (2006) Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesatan for prevention of Vascular Events (ACTIVE-W): a randomized controlled trial. Lancet 367: 1903–1912
Dahlof B, Devereux RB, Kjeldsen SE et al. (2002) Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 359: 995–1003
Diener HC, Allenberg JR, Bode C et al. (2007) Leitlinien der Deutschen Gesellschaft für Neurologie und der Deutschen Schlaganfallgesellschaft zur Primär-und Sekundärprävention des Schlaganfalls. Akt Neurol 34: 8–12
Diener HC, Bogousslavsky J, Brass LM et al. (2004) Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet 364: 331–337
Eames PJ, Blake MJ, Dawson SL et al. (2002) Dynamic cerebral autoregulation and beat to beat blood pressure control are impaired in acute stroke. J Neurol Neurosurg Psychiatry 72: 467–472
Esprit study group (2006) Aspirin plus dipyridamole versus aspirin alone after cerebral ischemia of arterial origin (ESPRIT): randomized controlled trial. Lancet 367: 1665–1673
Fayad P (2007) Endarterectomy and stenting for asymptomatic carotid stenosis: a race at breakneck speed. Stroke 38: 707–714
Gaede P, Vedel P, Larsen N, et al. (2003) Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med 348: 383–393
Goldstein LB, Adams R, Alberts MJ, et al. (2006) Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council. Stroke 37: 1583–1633
Healy JS, Baranchuk A, Crystal E (2005) Prevention of atrial fibrillation with Angiotensin-Converting enzyme inhibitors and Angiotensin Receptor Blockers. JACC 45: 1832–1839
Khaja, AM, Grotta JC (2007) Established treatments for acute ischaemic stroke. Lancet 369: 319–330
Leonardi-Bee L, Bath PM, Philips SJ, Sandercock PA (2002) Blood pressure and clinical outcomes in the International Stroke Trial. Stroke 33: 1315–1320
Lindholm LH, Carlberg B, Samuelsson O (2005) Should beta blockers remain first choice in the treatment of primary hypertension? A meta-analysis. Lancet 366: 1545–1553
MRC/BHF (2002) MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360: 7–22.
Sacco RL, Adams R, Sacco RL, Diener HC, Yusuf S (2008) Aspirin and Extended-Release Dipyridamole versus Clopidogrel for recurrent stroke. N Engl J Med 359: 1238–1251
Statistisches Bundesamt (2003) Statistisches Jahrbuch. Wiesbaden: Statistisches Bundesamt
Staessen JA, Wang JG, Thijs L (2001) Cardiovascular protection and blood pressure reduction: a meta-analysis. Lancet 358: 1305–1315
Wang X, Qin X, Demirtas H et al. (2007) Efficacy of folic acid supplementation in stroke prevention: a meta-analysis. Lancet 369: 1876–1882
Weimar C, Roth MP, Zillessen G et al. (2002) Complications following acute ischemic stroke. Eur Neurol 48: 133–140
Wilcox R, Bousser MG, Betteridge DJ, et al. (2007) Effects of pioglitazone in patients with type 2 diabetes with or without previous stroke: results from PROactive (PROspective pioglitAzone Clinical Trial In macroVascular Events). Stroke 38: 865–873
Williams B, Lacy PS, Thom SM, et al. (2006) Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation 113: 1213–1225
Literatur
Antman EM, Cohen M, Radley D et al. (1999) Assessment of the treatment effect of enoxaparin for unstable angina/non-Q-wave myocardial infarction. TIMI 11B-ESSENCE meta-analysis. Circulation 100: 1602–1608
ASSENT (Assessment of the Safety and Efficacy of a New Thrombolytic) Investigators (1999) Single-bolus tenecteplase compared with front-loaded alteplase in acute myocardial infarction: the ASSENT-2 double-blind randomised trial. Lancet 354: 716–722
ASSENT-3 (Assessment of the Safety and Efficacy of a New Thrombolytic Regimen) investigators (2001) Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: the ASSENT-3 randomised trial in acute myocardial infarction. Lancet 358: 605–613
Bassand JP, Hamm CW, Ardissino D et al.; Task Force for Diagnosis and Treatment of Non-ST-Segment Elevation Acute Coronary Syndromes of European Society of Cardiology (2007). The European Society of Cardiology Task Force Guidelines for diagnosis and treatment of non-ST-segment elevation acute coronary syndromes. Eur Heart J 28(13): 1598–660
Bonnefoy E, Lapostolle F, Leizorovicz A, Steg G, McFadden EP, Dubien PY, Cattan S, Boullenger E, Machecourt J (2002) Primary angioplasty versus prehospital fibrinolysis in acute myocardial infarction: a randomised study. Comparison of Angioplasty and Prehospital Thrombolysis in Acute Myocardial Infarction (CAP-TIM) study group. Lancet 360: 825–829
Buse JB, Ginsberg HN, Bakris GL et al. (2007) Primary Prevention of Cardiovascular Diseases in People With Diabetes Mellitus: A Scientific Statement From the American Heart Association and the American Diabetes Association. Circulation 115: 114–126
Cannon CP, Weintraub WS, Demopoulos LA et al.; for the TACTICS investigators (2001) Comparisons of early invasive and conservative strategies in patients with unstable coronary syndroms treated with the glycoprotein IIb/IIIa inhibitor tirofiban. N Engl J Med 344: 1879–1887
CAPTURE Investigators (1997) Randomised placebo-controlled trial of abciximab before and during coronary intervention in refractory unstable angina: the CAPTURE Study. Lancet 349: 1429–1435
Chen ZM, Jiang, LX, Chen YP, Xie JX, Pan HC, Peto R, Collins R, Liu LS (2005) Addition of clopidogrel to aspirin in 45.852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet 366: 1607–1621
Elad Y, French WJ, Shavelle DM et al. (2002) Primary angioplasty and selection bias inpatients presenting late (>12 h) after onset of chest pain and ST-elevation myocardial infarction. J Am Coll Cardiol 39: 826–833
Fox KAA, Poole-Wilson PA, Henderson RA et al. (2002) Interventional versus conservative treatment for patients with unstable angina or non-ST-elevation myocardial infarction: the British Heart Foundation RITA 3 randomised trial. Lancet 360: 743–751
FRISC II investigators (1999) Invasive compared with non-invasive treatment in unstable coronary-artery disease: FRISC II prospective randomised multicentre study. Fragmin and Fast Revascularisation during Instability in Coronary artery disease Investigators. Lancet 354: 708–715
Grines CL, Patel A, Zijlstra F et al. (2003) Primary coronary angioplasty compared with intravenous thrombolytic therapy for acute myocardial infarction: six-month follow up and analysis of individual patient data from randomized trials. Am Heart J 145: 47–57
GUSTO III (Global Use of Strategies to Open Occluded Coronary Arteries) Investigators (1997) A comparsion of reteplase with alteplase for acute myocardial infarction. N Engl J Med 337: 1118–1123
GUSTO Investigators (1993) An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. N Engl J Med 329: 673–682
Hamm CW (2004a) Akutes Koronarsyndrom. Z Kardiol 93: 72–90
Hamm CW (2004b) Leitlinien: Akutes Koronarsyndrom (ACS). Teil 1: ACS ohne persitierende ST-Hebung. Z Kardiol 93: 72–90
Hamm CW (2004c) Leitlinien: Akutes Koronarsyndrom (ACS). Teil 2: Akutes Koronarsyndrom mit ST-Hebung. Z Kardiol 93: 324–341
Hamm CW, Heeschen C, Goldmann B et al. (1999) Benefit of abciximab in patients with refractory unstable angina in relation to serum troponin T levels. N Engl J Med 340: 1623–162
Hochholzer W, Trenk D, Frundi D, Blanke P, Fischer B, Andris K, Bestehorn HP, Buttner HJ, Neumann FJ (2005) Time dependence of platelet inhibition after a 600-mg loading dose of clopidogrel in a large, unselected cohort of candidates for percutaneous coronary intervention. Circulation 111(20): 2560–4
Kalla K, Christ G, Karnik R et al. (2006) Implementation of guidelines improves the standard of care: the Viennese registry on reperfusion strategies in ST-elevation myocardial infarction (Vienna STEMI registry). Circulation 113: 2398–2405
Kastrati A, Mehilli J, Neumann F-J et al. (2006) Abciximab in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention After Clopidogrel Pretreatment. The ISAR-REACT 2 Randomized Trial. JAMA 295: 1531–1538
Keeley EC, Boura JA, Grines CL (2003) Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet 361: 13–20
Mehta SR (2005) Efficacy and safety of fondaparinux compared to enoxaparin in 20.000 high risk patients with ACS without ST-elevation: the OASIS 5 Michelangelo programme. Presented at the European Society of Cardiology congress; September 4.–7. 2005; Stockholm, Sweden
Neumann F-J, Kastrati A, Pogatsa-Murray G, Behilli J, Bollwein H, Bestehorn H-P, Schmitt C, Seyfarth M, Dirschinger J, Schömig A (2003) Evaluation of prolonged antithrombotic pretreatment (“cooling-off„ strategy) before intervention in patients with unstable coronary syndromes. JAMA 290: 1593–1599
Pearson TA, Blair SN, Daniels SR et al. (2002) AHA Guidelines for Primary Prvention of Cardiovascular Disease and Stroke: 2002 Update: Consensus Panel Guide to Comprehensive Risk Reduction for Adult Patients Without Coronary or Other Atherosclerotic Vascular Diseases. Circulation 106: 388–391
PRISM-PLUS Study Investigators (1998) Inhibition of the platelet glycoprotein IIb/IIIa receptor with tirofiban in unstable angina and non-Q-wave myocardial infarction. Platelet Receptor Inhibition in Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms (PRISM-PLUS) Study Investigators. N Engl J Med 338(21): 1488–97
PURSUIT Trial Investigators (1998) Inhibition of platelet glycoprotein IIb/IIIa with eptifibatide in patients with acute coronary syndromes. N Engl J Med 339(7): 436–43
Roe MT, Parsons LS, Jr. Pollack CV et al. (2005) Quality of care by classification of myocardial infarction: treatment patterns for ST-Segment elevation vs non-ST-Segment elevation myocardial infarction. Arch Intern Med 165: 1630–1636
Ross AM, Coyne KS, Reiner JS et al. (1999) A randomized trial comparing primary angioplasty with a strategy of short-acting thrombolysis and immediate planned rescue angioplasty in acute myocardial infarction: the PACT trial. PACT investigators. Plasminogen-activator Angioplasty Compatibility Trial. J AM Coll Cardiol 34: 1954–1962
Schömig A, Mehilli J, Antoniucci D, et al.; for the Beyond 12 hours Reperfusion AlternatiVe Evaluation (BRAVE-2) Trial Investigators (2005) Mechanical reperfusion in patients with acute myocardial infarction presenting more than 12 hours from symptom onset: a randomized controlled trial. JAMA 293(23): 2865–72
Smith SC, Allen J, Blair SN et al. (2006) AHA/ACC Guidelines for Secondary Prevention for Patients With Coronary and Other Atherosclerotic Vascular Disease: 2006 Update: Endorsed by the National Heart, Lung, and Blood Institute. Circulation 113: 2363–2372
Stone GW, Brodie BR, Griffin JJ et al. (1999) Clinical and aniographic follow-up after primary stenting in acute myocardial infarction: the primary angioplasty in myocardial infarction (PAMI) stent pilot trial. Circulation 99: 1548–1554
Stone GW, Moliterno DJ, Bertrand M et al. (2002) Impact of Clinical syndrome acuity on the differential response to 2 glycoprotein IIb/IIIa inhibitors in patients undergoind coronary stenting. Circulation 105: 2347–2354
Topol EJ; The GUSTO V investigators (2001) Reperfusion therapy for acute myocardial infarction with fibrinolytic therapy or combination reduced fibrinolytic therapy and platelet glycoprotein IIb/IIIa inhibitoren: the GUSTO V randomised trial. Lancet 357: 1905–1914
Weaver WD, Simes RJ, Betriu A et al. (1997) Comparison of primary coronary angioplasty and intravenous thrombolytic therapy for acute myocardial infarction: a quanitative review: JAMA 278: 2093–2098
Zahn R, Schile R, Schneider S et al. (2001) Primary angioplasty versus no reperfusion therapy in patients with acute myocardial infarction and a prehospital delay of >12–24 hours: results from the pooled data of the maximal individual therapy in acute myocardial infarction (MITRA) registry and the myocardial infarction registry (MIR). J Invasive Cardiol 13: 367–372
Zijlstra F, de Boer MJ, Hoorntje JC, Reiffers S, Reiber JH, Suryapranata H (1993) A comparison of immediate coronary angioplasty with intravenous streptokinase in acute myocardial infarction. N Engl J Med 328: 680–684
Literatur
Anand S, Yusuf S, Xie C et al.; Warfarin Antiplatelet Vascular Evaluation (WAVE) Trial Investigators (2007) Oral anticoagulant and antiplatelet therapy and peripheral arterial disease. N Engl J Med 357: 217–227
ATTC (Antiplatelet Trialists’ Collaboration) (1994) Collaborative Overview of randomised trials of antiplatelet therapy-I: prevention of death, myocardial infarction and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ 308: 81–106; Erratum in: BMJ 1994; 308: 1540
Beebe HG, Dawson DL, Cutler BS, et al. (1999) A new pharmacological treatment for intermittent claudication: results of a randomized, multicenter trial. Arch Intern Med 159: 2041–2050
Berger JS, Rioncaglioni MC, Avanzini F, Pangrazzi I, Tognoni G, Brown DL (2006) Aspirin for the primary prevention of cardiovascular events in women and men: a sex-specific meta-analysis of randomized controlled trials. JAMA 295: 306–313. Erratum in: JAMA 2006; 295: 2002
BOA (The Dutch Bypass Oral anticoagulants or Aspirin) Study Group (2000) Efficacy of oral anticoagulants compared with aspirin after infrainguinal bypass surgery (The Dutch Bypass Oral anticoagulants or Aspirin study): a randomised trial. Lancet 355: 346–351
CAPRIE-Steering Committee (1996) A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 348: 1329–1339
Cosmi B, Conti E, Coccheri S (2001) Anticoagulants (heparin, low molecular weight heparin and oral anticoagulants) for intermittent claudication. Cochrane Database Syst Rev: CD001999
Dawson DL, Cutler BS, Hiatt WR, Hobson RW 2nd, Martin JD, Bortey EB, Forbes WP, Strandness DE Jr (2000) A comparison of cilostatzol and pentoxifylline for treating intermittent claudication. Am J Med 109: 523–530
de Vries SO, Hunink MG (1997) Results of aortic bifurcation grafts for aortoiliac occlusive disease: a meta-analysis. J Vasc Surg 26: 558–569
Diehm C, Schuster A, Allenberg JR, Darius H, Haberl R, Lange S, Pittrow D, von Stritzky B, Tepohl G, Trampisch HJ (2004) High prevalence of peripheral arterial disease and co-morbidity in 6880 primary care patients: cross-sectional study. Atherosclerosis 172: 95–105
Douglas JS Jr (2005) Role of adjunct pharmacologic therapy in the era of drug-eluting stents. Atheroscler Suppl 6: 47–52
Elam MB, Heckman J, Crouse JR, Hunningshake DB, Herd JA, Davidson M, Gordon IL, Bortey EB, Forbes WP (1998) Effect of the novel antiplatelet agent cilostazol on plasma lipoproteins in patients with intermittent claudication. Arterioscler Thromb Vasc Biol 18: 1942–1947
Gotho F, Tohgi H, Hirai S (2000) Cilostazol Stroke Prevention Study: a placebo-controlled double-blind trial for secondary prevention of cerebral infarction. J Stroke Cerebrovasc Dis 9: 147–157
Hiatt WR, Regensteiner JG, Creager MA et al. (2001) Propionyl-L-carnitine improves exercise performance and functional status in patients with claudication. Am J Med 110: 616–622
Hiatt WR, Money SR, Brass EP (2008) Long-term safety of cilostazol in patients with peripheral artery disease: the CASTLE study (Cilostazol: A Study in Long-term Effects). J Vasc Surg. 47:330–336
Hirsch AT, Haskal ZJ, Hertzer NR et al. (2005) ACC/AHA 2005 Practice Guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic). Circulation 113: e463–654
Hood SC, Moher D, Barber GG (1996) Management of intermittent claudication with pentoxifylline: meta-analysis of randomized controlled trials. CMAJ 155: 1053–1059
Kannel WB, McGee DL (1985) Update on some epidemiologic features of intermittent claudication: the Framingham Study. J Am Geriatr Soc 33: 13–18
Klein WM, van der Graaf Y, Seegers J, Moll FL, Mali WP (2004) Long-term cardiovascular morbidity, mortality, and reintervention after endovascular treatment in patients with iliac artery disease: The Dutch Iliac Stent Trial Study. nRadiology 232: 491–498
Lederman RJ, Mendelsohn FO, Anderson RD et al.; TRAFFIC Investigators (2002) Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study): a randomised trial. Lancet 359: 2053–2058
Lehert P, Comte S, Gamand S, Brown TM (1994) Naftidrofuryl in intermittent claudication: a retrospective analysis. J Cardiovasc Pharmacol 23Suppl 3: 48–52
Leng GC, Fowler B, Ernst E (2000) Exercise for intermittent claudication. Cochrane Database Syst Rev. (2): CD000990
Maxwell AJ, Anderson BE, Cooke JP (2000) Nutritional therapy for peripheral arterial disease: a double-blind, placebo-controlled, randomized trial of HeartBar. Vasc Med 5: 11–19
Mohler ER 3rd, Hiatt WR, Creager MA (2003) Cholesterol reduction with atorvastatin improves walking distance in patients with peripheral arterial disease. Circulation. 108: 1481–6
Mondillo S, Ballo P, Barbati R, Guerini F, Ammaturo T, Agricole E, Pastore M, Borello F, Belcastro M, Picchi A, Nami R (2003) Effects of simvastatin on walking performance and symptoms of intermittent claudication in hypercholesterolemic patients with peripheral vascular disease. Am J Med 114: 359–364
Muntner P, Wildman RP, Reynolds K, Desalvo KB, Chen J, Fonseca V (2005) Relationship between HbA1c level and peripheral arterial disease. Diabetes Care 28: 1981–1987
Muradin GS, Bosch JL, Stijnen T, Hunink MG (2001) Balloon dilation and stent implantation for treatment of femoropopliteal arterial disease: meta-analysis. Radiology 221: 137–145
Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FG; TASC II Working Group (2007) Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II). J Vasc Surg 45 Suppl S: S5–67
Otsuki M, Saito H, Xu X, Sumitani S, Kouhara K, Kurabayashi M, Kasayama S (2001) Cilostazol represses vascular cell adhesion molecule-1 gene transcription via inhibiting NF-kappaB binding to its recognition sequence. Atherosclerosis 158: 121–128
Rajagopalan S, Mohler ER 3rd, Lederman RJ et al. (2003) Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent claudication. Circulation 108: 1933–1938
Regensteiner JG, Ware JE Jr, McCarthy WJ, Zang P, Forbes WP, Heckmann J, Hiatt WR (2002) Effect of cilostazol on treadmill walking, community-based walking ability, and health-related quality of life in patients with intermittent claudication due to peripheral arterial disease: meta-analysis of six randomized controlled trials. J Am Geriatr Soc 50: 1939–1946
Ridker PM, Stampfer MJ, Rifai N (2001) Novel risk factors for systemic atherosclerosis: a comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease. JAMA 285: 2481–2485
Rutherford RB, Baker JD, Ernst C, Johnston KW, Porter JM, Ahn S, Jones DN (1997) Recommended standards for reports dealing with lower extremity ischemia: revised version. J Vasc Surg 26: 517–538. Erratum in: J Vasc Surg 2001; 33: 805
Salomaa V, Matei C, Aleksic N, Sansores-Garcia L, Folsom AR, Juneja H, Par E, Wu KK (2001) Cross-sectional association of soluble thrombomodulin with mild peripheral artery disease; the ARIC study. Atherosclerosis Risk in Communities. Atherosclerosis 157: 309–314
Selvin E, Marinopoulos S, Berkenblit G, Rami T, Brancati FL, Powe NR, Golden SH (2004) Meta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus. Ann Intern Med 141: 421–431
Spengel F, Clement D, Boccalon H, Liard F, Brown T, Lehert P (2002) Findings of the Naftidrofuryl in Quality of Life (NIQOL) European study program. Int Angiol 21: 20–27
Takahashi S, Oida K, Fujiwara R, Maeda H, Hayashi S, Takai H, Tamai T, Nakai T, Miyabo S (1992) Effect of cilostazol, a cyclic AMP-phosphodiesterase inhibitor, on the proliferation of rat aortic smooth muscle cells in culture. J Cardiovasc Pharmacol 20: 900–906
Tzoulaki I, Murray GD, Lee AJ, Rumley A, Lowe GD, Fowkes FG (2007) Inflammatory, haemostatic, and rheological markers for incident peripheral arterial disease: Edinburgh Artery Study. Eur Heart J 28: 354–362
Woo SK, Kang WK, Kwon KI (2002) Pharmacokinetic and pharmacodynamic modeling of the antiplatelet and cardiovascular effects of cilostazol in healthy humans. Clin Pharmacol Ther 71: 246–52
Literatur
Ammaturo C, De RA, Salzano A et al. (2001) Intestinal infarction: report of 98 cases. Chir Ital 53: 57–64
Augsburger JJ, Magargal LE (1980) Visual prognosis following treatment of acute central retinal artery obstruction. Br J Ophthalmol 64: 913–7
Batellier J, Kieny R (1990) Superior mesenteric artery embolism: eightytwo cases. Ann Vasc Surg 4: 112–6
Bolderman R, Oyen R, Verrijcken A et al. (2006) Idiopathic renal infarction. Am J Med 119: 356–12
Domanovits H, Paulis M, Nikfardjam M et al. (1999) Acute renal infarction. Clinical characteristics of 17 patients. Medicine (Baltimore) 78: 386–94
Eckstein HH (2003) Acute mesenteric ischemia. Resection or reconstruction? Chirurg 74: 419–31
Feltgen N, Neubauer A, Jurklies B et al. (2006) Multicenter study of the European Assessment Group for Lysis in the Eye (EAGLE) for the treatment of central retinal artery occlusion: design issues and implications. EAGLE Study report no. 1. Graefes Arch Clin Exp Ophthalmol 244: 950–6
Framme C, Spiegel D, Roider J et al. (2001) Central retinal artery occlusion. Importance of selective intra-arterial fibrinolysis. Ophthalmologe 98: 725–30
Frippiat F, Donckier J, Vandenbossche P et al. (1996) Splenic infarction: report of three cases of atherosclerotic embolization originating in the aorta and retrospective study of 64 cases. Acta Clin Belg 51: 395–402
Guth AA, Pachter HL, Jacobowitz GR (1996) Rupture of the pathologic spleen: is there a role for nonoperative therapy? J Trauma 41: 214–8
Hazanov N, Somin M, Attali M et al. (2004) Acute renal embolism. Fortyfour cases of renal infarction in patients with atrial fibrillation. Medicine (Baltimore) 83: 292–9
Jaroch MT, Broughan TA, Hermann RE (1986) The natural history of splenic infarction. Surgery 100: 743–50
Lessman RK, Johnson SF, Coburn JW et al. (1978) Renal artery embolism: clinical features and long-term follow-up of 17 cases. Ann Intern Med 89: 477–82
Rivers SP, Veith FJ (2000) Nonocclusive mesenteric ischemia. In: Rutherford RB (ed) Vascular Surgery, 5th edition. Philadelphia: Saunders, p 1519–23
Schumacher M, Schmidt D, Wakhloo AK (1991) Intra-arterial fibrinolysis in central artery occlusion. Radiologe 31: 240–3
Tsai FY, Wadley D, Angle JF et al. (1990) Superselective ophthalmic angiography for diagnostic and therapeutic use. Am J Neuroradiol 11: 1203–4
van Geloven AA, Biesheuvel TH, Luitse JS et al. (2000) Hospital admissions of patients aged over 80 with acute abdominal complaints. Eur J Surg 166: 866–871
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Langer, H.F. et al. (2010). Arterielle Thromboembolien. In: Pötzsch, B., Madlener, K. (eds) Hämostaseologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01544-1_33
Download citation
DOI: https://doi.org/10.1007/978-3-642-01544-1_33
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-01543-4
Online ISBN: 978-3-642-01544-1
eBook Packages: Medicine (German Language)