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Keimzelltumoren bei Kindern und Jugendlichen

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Book cover Uroonkologie

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Zusammenfassung

Die Keimzelltumoren bei Kindern und Jugendlichen umfassen eine klinisch äußerst heterogene Gruppe von Tumoren, die bei Kindern überwiegend an extragonadalen mittelliniennahen Lokalisationen wie der Steißbeinregion, dem Mediastinum und dem zentralen Nervensystem auftreten. Hierdurch erklärt sich die Notwendigkeit der interdisziplinären Behandlung im Rahmen der aktuellen Therapieoptimierungsprotokolle. Keimzelltumoren zeigen im Kindes- und Jugendalter ein charakteristisches Muster der Alters- und Geschlechtsverteilung in Bezug auf die verschiedenen Lokalisationen und histologischen Subentitäten. Diese altersabhängigen Unterschiede korrelieren mit einer unterschiedlichen Tumorbiologie und Prognose. Allen Tumoren ist jedoch der zelluläre Ursprung von der totipotenten primordialen Keimzelle gemeinsam. Dabei leiten sich Tumoren verschiedener Lokalisationen offensichtlich von verschiedenen Entwicklungsstadien dieser primordialen Keimzellen ab.

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Literatur

  • Ablin AR (1981) Malignant germ cell tumors in children. Front Radiat Ther Oncol 16: 14–19

    Google Scholar 

  • Ablin AR, Krailo MD, Ramsay NK, Malogolowkin MH, Isaacs H, Raney RB et al. (1991) Results of treatment of malignant germ cell tumors in 93 children: a report from the Childrens Cancer Study Group. J Clin Oncol 9: 1782–92

    CAS  PubMed  Google Scholar 

  • Baranzelli MC, Bouffet E, Quintana E, Portas M, Thyss A, Patte C (2000) Non-seminomatous ovarian germ cell tumours in children. Eur J Cancer 36: 376–83

    Article  CAS  PubMed  Google Scholar 

  • Baranzelli MC, Kramar A, Bouffet E, Quintana E, Rubie H, Edan C et al. (1999) Prognostic factors in children with localized malignant nonseminomatous germ cell tumors. J Clin Oncol 17: 1212–9

    CAS  PubMed  Google Scholar 

  • Blohm ME, Vesterling-Hörner D, Calaminus G, Göbel U (1998) Alpha 1-fetoprotein (AFP) reference values in infants up to 2 years of age. Pediatr Hematol Oncol 15: 135–42

    Article  CAS  PubMed  Google Scholar 

  • Bussey KJ, Lawce HJ, Himoe E, Shu XO, Heerema NA, Perlman EJ et al. (2001) SNRPN methylation patierns in germ cell tumors as a reflection of primordial germ cell development. Genes Chromosomes. Cancer 32: 342–52

    CAS  Google Scholar 

  • Cushing B, Giller R, Cullen JW, Marina NM, Lauer SJ, Olson TA et al. (2004) Randomized comparison of combination chemotherapy with etoposide, bleomycin, and either high-dose or standard-dose cisplatin in children and adolescents with high-risk malignant germ cell tumors: a pediatric intergroup study — Pediatric Oncology Group 9049 and Children’s Cancer Group 8882. J Clin Oncol 22: 2691–700

    Article  CAS  PubMed  Google Scholar 

  • Ernestus K, Pietsch T, Gessler M, Simon T, Hero B, Berthold F (2006) Structure, use, and risks of biomaterial repositories of embryonal tumors. Klin Pädiatr 218:132–8

    Article  CAS  PubMed  Google Scholar 

  • Flamant F, Schwartz L, Delons E, Caillaud JM, Hartmann O, Lemerle J (1984) Nonseminomatous malignant germ cell tumors in children. Multidrug therapy in stages III. and IV. Cancer 54: 1687–91

    Article  CAS  PubMed  Google Scholar 

  • Frappaz D, Conter C (2007) Testicular neoplasms in children: lymphatic or metastatic involvement is rare. Rev Prat 57: 368–9

    PubMed  Google Scholar 

  • Göbel U, Calaminus G, Engert J, Kaatsch P, Gadner H, Bökkerink JP et al. (1998) Teratomas in infancy and childhood. Med Pediatr Oncol 31: 8–15

    Article  PubMed  Google Scholar 

  • Göbel U, Calaminus G, Teske C, Bamberg M, Bokkerink JP, Haas RJ et al. (1993) BEP/VIP in children and adolescents with malignant non-testicular germ cell tumors. A comparison of the results of treatment of therapy studies MAKEI 83/86 and 89P/89. Klin Pädiatr 205: 231–40

    Article  PubMed  Google Scholar 

  • Göbel U, Gutiahr P, Jürgens H, Kabisch H, Lampert F, Spaar HJ et al. (1986) Cooperative therapy study of nontesticular germ cell tumors MAKEI 83 of the Society of Pediatric Oncology: analysis after 3 ye: ars. Klin Padiatr 198: 237–44

    Article  PubMed  Google Scholar 

  • Göbel U, Schneider DT, Calaminus G, Haas RJ, Schmidt P, Harms D (2000) Germ-cell tumors in childhood and adolescence. Ann Oncol 11: 263–71

    Article  PubMed  Google Scholar 

  • Göbel U, Schneider DT, Calaminus G, Jürgens H, Spaar HJ, Sternschulte W et al. (2001) Multimodal treatment of malignant sacrococcygeal germ cell tumors: a prospective analysis of 66 patients of the german cooperative protocols MAKEI 83/86 and 89. J Clin Oncol 19: 1943–50

    PubMed  Google Scholar 

  • Haas RJ, Göbel U, Harms D, Schmidt P, Weissbach L (1988) Results of the cooperative Malignant Testicular Tumors 82 Study of the German Society of Pediatric Oncology on the therapy of malignant germ cell tumors in childhood. Klin Padiatr 200: 230–5

    Article  CAS  PubMed  Google Scholar 

  • Haas RJ, Schmidt P, Göbel U, Harms D (1995) Testicular germ cell tumors. Results of the GPO MAHO studies −82, −88, −92. Klin Pädiatr 207: 145–50

    Article  CAS  PubMed  Google Scholar 

  • Harms D, Jänig U (1986) Germ cell tumours of childhood. Report of 170 cases including 59 pure and partial yolk-sac tumours. Virchows Arch A Pathol Anat Histopathol 409: 223–39

    Article  CAS  PubMed  Google Scholar 

  • Harms D, Zahn S, Göbel U, Schneider DT (2006) Pathology and molecular biology of teratomas in childhood and adolescence. Klin Pädiatr 218: 296–302

    Article  CAS  PubMed  Google Scholar 

  • Heidenreich A, Weissbach L, Holtl W, Albers P, Kliesch S, Kohrmann KU et al. (2001) Organ sparing surgery for malignant germ cell tumor of the testis. J Urol 166: 2161–5

    Article  CAS  PubMed  Google Scholar 

  • Kaatsch P, Kaletsch U, Michaelis J (2004) Annual Report of the German Childhood Cancer Registry. www.kinderkrebsregister.de

    Google Scholar 

  • Lopes LF, Sonaglio V, Ribeiro KC, Schneider DT, de CB (2008) Improvement in the outcome of children with germ cell tumors. Pediatr Blood Cancer 50: 250–3

    Article  PubMed  Google Scholar 

  • Mann JR, Raafat F, Robinson K, Imeson J, Gornall P, Phillips M et al. (1998) UKCCSG’s germ cell tumour (GCT) studies: improving outcome for children with malignant extracranial non-gonadal tumours — carboplatin, etoposide, and bleomycin are effective and less toxic than previous regimens. United Kingdom Children’s Cancer Study Group. Med Pediatr Oncol 30: 217–27

    Article  CAS  PubMed  Google Scholar 

  • Mann JR, Raafat F, Robinson K, Imeson J, Gornall P, Sokal M et al. (2000) The United Kingdom Children’s Cancer Study Group’s Second Germ Cell Tumor Study: Carboplatin, etoposide, and bleomycin are effective treatment for children with malignant extracranial germ cell tumors, with acceptable toxicity. J Clin Oncol 18: 3809–18

    CAS  PubMed  Google Scholar 

  • Mayer F, Gillis AJ, Dinjens W, Oosterhuis JW, Bokemeyer C, Looijenga LH (2002) Microsatellite instability of germ cell tumors is associated with resistance to systemic treatment. Cancer Res 62: 2758–60

    CAS  PubMed  Google Scholar 

  • Oosterhuis JW, Looijenga LH (2005) Testicular germ-cell tumours in a broader perspective. Nat Rev Cancer 5: 210–22

    Article  CAS  PubMed  Google Scholar 

  • Palmer RD, Barbosa-Morais NL, Gooding EL, Muralidhar B, Thornton CM, Pett MR et al. (2008) Pediatric malignant germ cell tumors show characteristic transcriptome profilles. Cancer Res 68: 4239–47

    Article  CAS  PubMed  Google Scholar 

  • Palmer RD, Foster NA, Vowler SL, Roberts I, Thornton CM, Hale JP et al. (2007) Malignant germ cell tumours of childhood: new associations of genomic imbalance. Br J Cancer 96: 667–76

    Article  CAS  PubMed  Google Scholar 

  • Schmidt P, Haas RJ, Göbel U, Calaminus G (2002) Results of the German studies (MAHO) for treatment of testicular germ cell tumors in children—an update. Klin Padiatr 214: 167–72

    Article  CAS  PubMed  Google Scholar 

  • Schmoll HJ, Kollmannsberger C, Metzner B, Hartmann JT, Schleucher N, Schoffski P et al. (2003) Long-term results of first-line sequential high-dose etoposide, ifosfamide, and cisplatin chemotherapy plus autologous stem cell support for patients with advanced metastatic germ cell cancer: an extended phase I/II study of the German Testicular Cancer Study Group. J Clin Oncol 21: 4083–91

    Article  CAS  PubMed  Google Scholar 

  • Schneider DT, Calaminus G, Reinhard H, Gutjahr P, Kremens B, Harms D et al. (2000) Primary mediastinal germ cell tumors in children and adolescents: results of the German Cooperative Protocols MAKEI 83/86, 89, and 96. J Clin Oncol 18:832–9

    CAS  PubMed  Google Scholar 

  • Schneider DT, Schuster AE, Fritsch MK, Hu J, Olson T, Lauer S et al. (2001) Multipoint imprinting analysis indicates a common precursor cell for gonadal and nongonadal pediatric germ cell tumors. Cancer Res 61: 7268–76

    CAS  PubMed  Google Scholar 

  • Schneider DT, Calaminus G, Göbel U (2001) Diagnostic value of alpha1-fetoprotein and human chorionic gonadotropic hormone in infancy and childhood. Pediatr Hematol Oncol 18: 11–26

    Article  CAS  PubMed  Google Scholar 

  • Schneider DT, Calaminus G, Koch S, Teske C, Schmidt P, Haas RJ et al. (2004) Epidemiological analysis of 1442 children and adolescents registered in the german germ cell tumor protocols. Pediatr Blood Cancer 169–75

    Google Scholar 

  • Schneider DT, Calaminus G, Harms D, Gobel U (2005) Ovarian sex cord-stromal tumors in children and adolescents. J Reprod Med 50: 439–46

    PubMed  Google Scholar 

  • Schneider DT, Zahn S, Sievers S, Alemazkour K, Reifenberger G, Wiestler OD et al. (2006) Molecular genetic analysis of central nervous system germ cell tumors with comparative genomic hybridization. Mod Pathol 19: 864–73

    CAS  PubMed  Google Scholar 

  • Skakkebaek NE (2004) Testicular dysgenesis syndrome: new epidemiological evidence. Int J Androl 27: 189–91

    Article  PubMed  Google Scholar 

  • Tröbs RB, Krauss M, Geyer C, Tannapfel A, Körholz D, Hirsch W (2007) Surgery in infants and children with testicular and paratesticular tumours: a single centre experience over a 25-year-period. Klein Padiatr 219: 146–51

    Article  Google Scholar 

  • Wessalowski R, Schneider DT, Mils O, Hannen M, Calaminus G, Engelbrecht V et al. (2003) An approach to cure: PEI chemotherapy and regional deep hyperthermia in children and adolescents with unresectable malignant tumors. Klin Pädiatr 215: 303–9

    Article  CAS  PubMed  Google Scholar 

  • Zahn S, Sievers S, Alemazkour K, Orb S, Harms D, Schulz WA et al. (2006) Imbalances of chromosome 1p in pediatric and adult germ cell tumors are caused by true allelic loss: a combined comparative genomic hybridization and microsatellite analysis. Genes Chromosomes. Cancer 45: 995–1006

    CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Klinik für Kinder- und Jugendmedizin, Klinikum Dortmund GmbH, Beurhausstraße 40, 44137, Dortmund

    Priv. Doz. Dr. med. Dominik Schneider

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  1. Priv. Doz. Dr. med. Dominik Schneider
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Editors and Affiliations

  1. Universitätsklinikum Essen, Hufelandstraße 55, 45122, Essen

    Herbert Rübben (Direktor der Klinik und Poliklinik für Urologie) (Direktor der Klinik und Poliklinik für Urologie)

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© 2009 Springer Medizin Verlag Heidelberg

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Schneider, D. (2009). Keimzelltumoren bei Kindern und Jugendlichen. In: Rübben, H. (eds) Uroonkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01382-9_32

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  • DOI: https://doi.org/10.1007/978-3-642-01382-9_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-01381-2

  • Online ISBN: 978-3-642-01382-9

  • eBook Packages: Medicine (German Language)

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