Abstract
Common chronic wounds, including pressure ulcers, diabetic foot ulcers, arterial and venous ulcers often involve damage to adipose tissue. In addition, defects or deficiencies in adipose tissue can occur due to lipoatrophies, trauma, and tumor resection. Clinical treatment options vary, but it is difficult to specifically regenerate or reconstruct adipose tissue. Materials that promote adipose regeneration have the potential to serve as alternatives or supplements to current treatments options. However, the majority of attempts to engineer adipose tissue have used standard synthetic or natural materials as scaffolds with little consideration of unique features of the adipose extracellular microenvironment. The extracellular matrix is different in composition and structure in every tissue and these differences play an important role in cell behavior and tissue function. An ideal material would account for these differences. Based on this knowledge a technique was developed where hydrogels can be extracted and assembled from any soft tissue. The structure, composition, and biological properties of these hydrogels vary depending on the tissue used for extraction and the mechanism of gelation. Hydrogels derived from adipose tissue using this technique promote greater preadipocyte differentiation in vitro and vascularized adipose formation in vivo than what has been observed with other materials in the absence of exogenous cells or growth factors. These complex, multi-component hydrogels hold great promise for soft tissue reconstruction.
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Cheng, M.D.MH., Uriel, S., Brey, E.M. (2009). Tissue-Derived Materials for Adipose Regeneration. In: Gefen, A. (eds) Bioengineering Research of Chronic Wounds. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00534-3_13
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DOI: https://doi.org/10.1007/978-3-642-00534-3_13
Publisher Name: Springer, Berlin, Heidelberg
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