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Fat Transfer with Platelet-Rich Plasma for Breast Augmentation

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Autologous Fat Transfer

Abstract

Tissue augmentation with autologous elements is considered the ideal choice for transplantation and volume augmentation surgery. It is well recognized that the ideal graft tissue should offer the standard features of being readily available, have low antigenicity, minimal donor site morbidity, predictable and reproducible retention, and avoid disease transmission. Gradual standardization of consistent harvesting, manipulations, and transfer protocols is improving the ability to accurately predict volume enhancements and appreciate the long-term survival of the grafted tissues. Platelets actively extrude multiple growth factors very important to early wound healing processes. In response to platelet-to-platelet or platelet-to-connective tissue contact, the platelet cell membrane is “activated” to release these products from the alpha granules via active extrusion. When these extruded growth factors are released, histones and carbohydrate chains are added to receptor sites, thereby creating their unique chemistries and make the “active” growth factors. Autologous fat grafting offers a viable and safe alternative means of breast augmentation in select patients. Platelet rich plasma enhances the fat transfer to the breast.

The author has no financial interest in Harvest Technology, Tulip Medical, or Shippert Medical companies.

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Authors and Affiliations

  1. Department of Surgery, University of Washington, Seatle, WA, USA

    Robert W. Alexander

  2. 3500 188th St.S.W. Suite 670, Lynnwood, WA, 98037, USA

    Robert W. Alexander

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  1. Tustin, California, USA

    Melvin A. Shiffman

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Alexander, R.W. (2010). Fat Transfer with Platelet-Rich Plasma for Breast Augmentation. In: Shiffman, M. (eds) Autologous Fat Transfer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00473-5_33

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