Autophagy in Mammalian Antiviral Immunity

  • Anthony Orvedahl
  • Beth LevineEmail author
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 335)


Autophagy plays diverse roles in cellular adaptation to stress and promotes vital housekeeping functions by recycling unused or damaged organelles and proteins. As an innate immune defense pathway, autophagy also protects against infection with diverse pathogens, including viruses. Autophagy combats infections with both RNA and DNA viruses, and may function by degrading viral components, by promoting the survival of virally infected cells, and/or by activating innate and adaptive immunity. Viruses have evolved counter-mechanisms to evade host autophagy in order to promote their own survival. This chapter will highlight recent advances and unanswered questions relating to autophagy in mammalian antiviral immunity.


Human Immunodeficiency Virus Autophagy Induction Sindbis Virus Viral Component Autophagy Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We apologize to authors whose work could not be included due to space restrictions. We thank Deborah Shaw for administrative support. The work in the authors’ laboratory was supported by NIH grants R01 A10151367 (B.L.) and T32 A1007520 (A.O), and an Ellison Medical Foundation Senior Scholars Award in Infectious Diseases (B.L.).


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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  1. 1.Department of Internal MedicineUniversity of Texas Southwestern Medical CenterDallasUSA
  2. 2.Department of MicrobiologyUniversity of Texas Southwestern Medical CenterDallasUSA
  3. 3.Department of Internal MedicineUniversity of Texas Southwestern Medical CenterDallasUSA
  4. 4.Department of MicrobiologyUniversity of Texas Southwestern Medical CenterDallasUSA
  5. 5.Howard Hughes Medical InstituteUniversity of Texas Southwestern Medical CenterDallasUSA

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