Physiology and Genetics

Volume 15 of the series The Mycota pp 233-245


Identification of Fungicide Targets in Pathogenic Fungi

  • Andrew J. FosterAffiliated withInstitut für Biotechnologie und Wirkstoff-Forschung e.V., Institute for Biotechnology and Drug Research Email author 
  • , Eckhard Thines

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The rapid emergence of fungicide resistance has brought a strong demand for plant protectants with a new mode of action. One of the challenges for modern plant pathology research is the identification of genes and gene products essential for the establishment of pathogenic interactions between host and pathogen. Genome-wide technologies, such as transcriptomics, metabolomics, and proteomics represent a new opportunity to identify such targets in phytopathogenic fungi. This chapter reviews genome-wide approaches that have emerged in the post-genomics era, e.g. comparative genomics and gene expression profiling experiments such as microarray-based transcriptional profiling, serial analysis of gene expression, and massively parallel signature sequencing. It also discusses prospects for exploiting these modern technologies for the development of plant protectants and system biology.