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Pancreatology pp 63–73Cite as

Bioecological Control of Disease, Especially Pancreatic Disease

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Abstract

Patients with acute pancreatitis often suffer an uncontrolled superinflammation, and as a result of that a malfunctioning innate immune system, which frequently leads to complications: severe infections, systemic inflammatory syndrome, and sometimes multiple organ failure. Among the characteristics of the superinflammation are an exuberant, e.g., exaggerated and prolonged, inflammatory response, an aberrant cellular response, and extreme elevations in levels of cytokines and acute-phase proteins but also in levels of coagulation and growth factors. The cytokine storm, which occurs during the first few hours, will almost immediately reach the lungs and other distant organs via the lymphatics 1], and will condition them to be/make them susceptible to a subsequent infection. Overgrowth of potentially pathogenic microorganisms in the stomach and intestines, due to disease, inhibition of gastric and gastrointestinal (GI) secretions, and absence of a food stream, provides the source of bacteria for subsequent infection of the chest, pancreas, urinary tract, and other organs.

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Author information

Authors and Affiliations

  1. Institute of Hepatology, University College London Medical School, 185 Barrier Point Road, Royal Docks, London, E16 2SE, UK

    S. Bengmark

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  1. S. Bengmark
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Correspondence to S. Bengmark .

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Editors and Affiliations

  1. Unité 624, Stress Cellulaire, Centre de Recherche INSERM, av. de Luminy 163, Marseille, 13288, France

    Juan Iovanna

  2. Centre of Hepatobiliary, Pancreatic Surgery, Tashkent Medical Academy, S. Azimov St. 74, Tashkent, 700062, Uzbekistan

    Uktam Ismailov

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© 2009 Springer-Verlag Berlin Heidelberg

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Bengmark, S. (2009). Bioecological Control of Disease, Especially Pancreatic Disease. In: Iovanna, J., Ismailov, U. (eds) Pancreatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-00152-9_7

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  • DOI: https://doi.org/10.1007/978-3-642-00152-9_7

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-00151-2

  • Online ISBN: 978-3-642-00152-9

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