Toll-Like Receptors

  • Gyongyi SzaboEmail author
  • Pranoti Mandrekar


Since the discovery of toll-like receptors (TLRs) in ­Dro­sophila in 1996 [1], scientific knowledge has exploded on the role of pattern recognition receptors in immunity, host defense, and in various noninfectious conditions including liver diseases. Studies demonstrated that TLR expression in immune and nonimmune cells plays an important role in tissue homeostasis, response to infections, and injury in the liver. Links between TLR activation and modulation of functions of TLRs in liver diseases are being discovered. Here, we discuss the characteristics and signaling pathways of TLRs and summarize current knowledge on their role in liver diseases.


Kupffer Cell Alcoholic Hepatitis TLR4 Activation Biliary Epithelial Cell TLR4 Coreceptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Department of MedicineUniversity of Massachusetts Medical SchoolWorcesterUSA

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