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Calcium Signaling

  • Thierry TordjmannEmail author
Chapter

Abstract

In normal eukaryotic cells, the concentration of free Ca2+ in the cytosol ([Ca2+]i) is actively kept much lower (100–200 nM) than extracellular (1–2 mM) and endoplasmic reticulum (ER) (0.5 mM) Ca2+ concentrations [1]. The cytosol, with its very low concentration of free calcium, is located at the interface of these two highly calcium-rich environments. This results in the cytosol, being a site of major and rapid variations in [Ca2+]i in response to the transfer of small quantities of Ca2+ from the extracellular medium or intracellular storage compartments [2]. These variations in [Ca2+]i (“calcium signals”), induced by agonists such as hormones and neurotransmitters, constitute a kind of language which is translated into physiological responses by the cells. Such calcium signals, highly organized in space and time, orchestrate a wide array of physiological processes from the subcellular to the whole tissue ­levels [2 –4].

Keywords

Liver Regeneration Calcium Signal Endoplasmic Reticulum Calcium InsP3 Receptor Intracellular Calcium Wave 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.INSERM U757Université Paris sudOrsayFrance

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