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VEGF Signaling

  • David Semela
  • Jean-François DufourEmail author
Chapter

Abstract

Vascular endothelial growth factor (VEGF) is the main growth factor for angiogenesis and vasculogenesis. Identified as a vascular endothelial cell mitogen and survival factor, it has been sequenced and cloned by Ferrara and Connolly in 1989 [1, 2]. Intense research over the past years has deciphered the gene, molecular pathways, receptors, and functions of this angiogenic factor [3]. VEGF plays a key role in liver regeneration, hepatic fibrogenesis, portal hypertension, hepatocarcinogenesis, and malignant ascites formation.

Keywords

Vascular Endothelial Growth Factor Vascular Endothelial Growth Factor Receptor Vascular Endothelial Growth Factor Expression Liver Regeneration Hepatic Stellate Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Institute of Clinical Pharmacology and Visceral ResearchUniversity of BernBernSwitzerland

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