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Sonic Hedgehog Pathway

  • Alessia Omenetti
  • Anna Mae DiehlEmail author
Chapter

Abstract

The Hedgehog (Hh) Pathway, originally identified in Drosophila, [1–4] is a highly conserved signaling pathway which orchestrates multiple, disparate aspects of embryogenesis, development and tissue remodeling in a wide spectrum of systems [5–8]. This is usually accomplished by autocrine/paracrine signaling and aims to control the size and localization of Hh-responsive cell populations in response to local/long distance signals [7, 9]. Hh pathway activation typically enhances the growth and viability of Hh-responsive cells, whereas abrogating Hh signal transduction usually triggers apoptosis in such cells, unless other locally available differentiating factors expedite cellular differentiation to a more mature phenotype that no longer requires Hh viability signals [5, 9]. Thus, up-/down-regulation of the Hh pathway provides a selective growth advantage for cell types that are capable of responding to Hh ligands, when compared to neighboring cells that lack Hh receptors. This leads to ­expansion/contraction, respectively, of Hh-responsive cells, thereby, orchestrating the cellular composition of several tissues [5–7, 9].

Keywords

Primary Biliary Cirrhosis Bile Duct Ligation Alcoholic Hepatitis Hedgehog Pathway Mature Hepatocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Department of Medicine, Division of GastroenterologyDuke University Medical Center, GSRBIDurhamUSA

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