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JNKs in liver diseases

  • R. SchwabeEmail author
Chapter

Abstract

c-Jun NH2-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family. Like other MAPKs, JNKs are conserved throughout eukaryotic evolution, activated via three-tiered phosphorylation cascades, and involved in a wide range of cellular responses to stress. JNKs have been shown to play important roles in proliferation, cell death, inflammation and cell metabolism. These seemingly unrelated responses are part of an overall stress response program that ensures proper repair of cells sustaining minor damage, elimination of cells sustaining irreversible structural or genetic damage, as well as their proper replacement.

Keywords

Liver Injury Liver Regeneration Hepatic Stellate Cell Hepatocyte Cell Death Hepatic Reperfusion Injury 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

This work was supported by NIH grants R01DK076920 and U54CA126513.

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© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Department of Medicinecolumbia UniversityNew YorkUSA

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