Abstract
Yanagimachi R. et al. (1976) The use of zona-free animal ova as a test system for the assessment of the fertilizing capacity of human spermatozoa. Biol.Reprod. 15: 471-476 The hamster egg penetration test (HEPT) is a sperm function assay that is based on the capacity of human spermatozoa to fuse with zona pellucida-free golden hamster oocytes, leading to subsequent decondensation of the sperm nuclei. The assay is terminated prior to nuclear fusion and before formation of the zygote is completed.29. The assay is used for testing the fertilisation capacity of human sperm specimens for medical purposes. The new assay was thought to reduce wastage of precious oocytes and costly in vitro fertilisation (IVF) cycles.
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Bernhard, HP. (2009). Case 8 – Yanagimachi: Hamster egg penetration test. In: Taupitz, J., Weschka, M. (eds) CHIMBRIDS - Chimeras and Hybrids in Comparative European and International Research. Veröffentlichungen des Instituts für Deutsches, Europäisches und Internationales Medizinrecht, Gesundheitsrecht und Bioethik der Universitäten Heidelberg und Mannheim, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-93869-9_14
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DOI: https://doi.org/10.1007/978-3-540-93869-9_14
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