Abstract
Using microcell mediated chromosome transfer most (92%) of human chromosome 21 was inserted into a mouse embryonic stem cell line. These cells were used to generate a transchromosomic mouse line carrying and inheriting the human chromosome. Proof of principle: it is possible to generate a transchromosomic mouse line with a (nearly) complete human chromosome. To generate a model for human trisomy 21 To use the model to study pathogenesis and develop treatment options for this disease
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© 2009 Springer-Verlag Berlin Heidelberg
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Bader, M. (2009). Case 7 – O’Doherty: Mouse with human chromosome. In: Taupitz, J., Weschka, M. (eds) CHIMBRIDS - Chimeras and Hybrids in Comparative European and International Research. Veröffentlichungen des Instituts für Deutsches, Europäisches und Internationales Medizinrecht, Gesundheitsrecht und Bioethik der Universitäten Heidelberg und Mannheim, vol 34. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-93869-9_13
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DOI: https://doi.org/10.1007/978-3-540-93869-9_13
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