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Drug Addiction as a Non-monotonic Process: a Multiscale Computational Model

  • Conference paper
13th International Conference on Biomedical Engineering

Part of the book series: IFMBE Proceedings ((IFMBE,volume 23))

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Abstract

Addiction is considered a “bio-psycho-socialspiritual disorder” [1] for which complete recovery cannot be assured. Although addiction was computationally characterized as a non-reversible process [2, 3], behavioral evidences support the possibility of recovery [4, 5, 6, 7].

We thus propose to consider addiction as a non-monotonic dynamical disease. Previously, we presented a multiscale computational model that combines three scales of observations: behavior, cognition, and neuropsychology. This model evaluates the drug-seeking behavior in virtual subjects.

We use our model to analyze dynamical properties of two typical virtual subjects. One has become an addict at the age of 17 and has since expressed a severe multi relapse pattern. The other one was exposed to addictive behavior at age 36 but managed to cease drug seeking. The results are encouraging for further explorations into the individual dynamics in addicts.

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Author information

Authors and Affiliations

  1. Department of Computer Science, Laboratory of Biologically Inspired Neural and Dynamical Systems (BINDS), University of Massachusetts Amherst, 140 Governors Drive, Amherst, MA, USA

    Y. Z. Levy & H. T. Siegelmann

  2. Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel

    D. Levy

  3. Laboratory of Developmental Neuropharmacology, University of Massachusetts Amherst, USA

    J. S. Meyer

Authors
  1. Y. Z. Levy
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  2. D. Levy
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  3. J. S. Meyer
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  4. H. T. Siegelmann
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Editor information

Editors and Affiliations

  1. Division of Bioengineering & Department of Mechanical Engineering Faculty of Engineering, National University of Singapore, 7 Engineering Drive 1 Block E3A #04-15, Singapore, 117574

    Chwee Teck Lim

  2. Department of Orthopaedic Surgery, YLL School of Medicine & Division of Bioengineering, Faculty of Engineering & NUS Tissue Engineering Program, Life Sciences Institute, Level 4, DSO (Kent Ridge) Building 27 Medical Drive, Singapore, 117510

    James C. H. Goh

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© 2009 International Federation of Medical and Biological Engineering

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Levy, Y.Z., Levy, D., Meyer, J.S., Siegelmann, H.T. (2009). Drug Addiction as a Non-monotonic Process: a Multiscale Computational Model. In: Lim, C.T., Goh, J.C.H. (eds) 13th International Conference on Biomedical Engineering. IFMBE Proceedings, vol 23. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-92841-6_419

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  • DOI: https://doi.org/10.1007/978-3-540-92841-6_419

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-92840-9

  • Online ISBN: 978-3-540-92841-6

  • eBook Packages: EngineeringEngineering (R0)

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