The Role of Simplifying Models in Neuroscience: Modelling Structure and Function

  • Dina M. Kronhaus
  • Stephen J. Eglen
Part of the Lecture Notes in Computer Science book series (LNCS, volume 5151)


The adult human brain has around 1011 neurons and 1015 connections between these neurons, thus forming an incredibly complex network. In this article, we first describe two complementary approaches to modelling brain function, namely simplifying and realistic models. We then demonstrate, by way of two examples, the utility of building simplifying neural models. In the first example, we consider the development of neuronal positioning. In the second example, we investigate the stability of a cortical network under control and perturbed conditions.


simplifying neural models retinal mosaics cortical compensation anterior cingulate 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Dina M. Kronhaus
    • 1
  • Stephen J. Eglen
    • 2
  1. 1.Computer LaboratoryCambridge UniversityUK
  2. 2.Cambridge Computational Biology InstituteUK

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