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Part of the book series: IFMBE Proceedings ((IFMBE,volume 22))

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Abstract

Stents are largely used to counteract and relieve duct or vessel obstructions. The purpose of this current study is to select a biodegradable, antibacterial and environmentally friendly material to design and prepare a stent to counteract anastomotic leakage following gastrointestinal surgery. A precast moulding process was used to prepare medium molecular weight chitosan scaffolds, for stent design. Chitosan samples were prepared by opening the bonds of the material in acetic acid, moulding the material and curing the mouldings in sodium hydroxide. The film like mouldings were wound around a metallic rod, fixing the layers together with un-cured chitosan and subsequently curing the chitosan layers together with sodium hydroxide producing the stent like shape. Tensile and tensile creep strength of the chitosan material was investigated. This research concluded that chitosan can be moulded into a stent like geometry. Mechanical testing showed the tensile and tensile creep strength were repeatable and could be predetermined. This indicates that chitosan is a suitable material for the further development of a biodegradable stent designed to counteract gastrointestinal leakage.

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References

  1. Sina Dorudi, Robert JC Steele & Colin S. McArdle, (2002) surgery for colorectal cancer, British medical bulletin 64: 101–118.

    Article  Google Scholar 

  2. CRC Cancerstats, (1999) London: Cancer research campaign.

    Google Scholar 

  3. Global cancer facts and figures (2007), American cancer society.

    Google Scholar 

  4. B. J. Moran & R. J. Heard, (2000) risk factors for and management of anastomotic leakage in rectal surgery, Blackwell Science Ltd. Colorectal Disease, 3, 135–137.

    Google Scholar 

  5. Anthony S. Mee, (2000) expandable metal stents in malignant colorectal obstruction, British medical journal 321(7261): 584–585.

    Article  Google Scholar 

  6. Chien Yuh Yeh et al, (2005) pelvic drainage and other risk factors for leakage after elective anterior resection in rectal cancer patients, Annals of surgery, 241(1), 9–13.

    Google Scholar 

  7. Michael Lim et al, 2005 clinical and subclinical leaks after low colorectal anastomosis, Disease of the colon and rectum 49: 1611–1619.

    Article  Google Scholar 

  8. Hok-Kwok Choi et al, (2006) leakage after resection and intraperitonal anastomosis for colorectal malignancy, Disease of the colon and rectum 49: 1719–1725.

    Article  Google Scholar 

  9. Iruru Maetani et al, (2005) technical tips for stent placement in the proximal colon using knitted esophageal stent, Digestive endoscopy 17, 334–337.

    Article  Google Scholar 

  10. S. Athreya et al, (2006) colorectal stenting for colonic obstructions, European journal of radiology 60,1: 91–94.

    Article  MathSciNet  Google Scholar 

  11. Thomas Scileppi et al, (2005) the use of a Polyflex coated esophageal stent to assist in the closure of a colonic anastomotic leak, gastrointestinal endoscopy 62,4: 643–645.

    Article  Google Scholar 

  12. Makoto Obayashi et al, (2002) endoscopic placement of a metallic stent for colonic stricture resulting from carcinoma located at the splenic flexure, digestive endoscopy 14: 123–127.

    Article  Google Scholar 

  13. A. Lauto et al, (2001) self-expandable chitosan stent: design and preparation, Elsevier, biomaterials 22, 1869–1874.

    Google Scholar 

  14. Yawo-Kuo et al, 2005 Preparation of novel chitosan scaffolds by electrochemical process, Elsevier, carbohydrate polymers 62, 113–119.

    Google Scholar 

  15. James M. Pachence et al, (2000) biodegradable polymers, principles of tissue engineering, 2nd edition, chapter 22, 265–266.

    Google Scholar 

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© 2009 Springer-Verlag Berlin Heidelberg

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Rothwell, R.A., Thomson, G.A., Pridham, M.S. (2009). Stent Design for Gastrointestinal Leakage. In: Vander Sloten, J., Verdonck, P., Nyssen, M., Haueisen, J. (eds) 4th European Conference of the International Federation for Medical and Biological Engineering. IFMBE Proceedings, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-89208-3_518

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  • DOI: https://doi.org/10.1007/978-3-540-89208-3_518

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-89207-6

  • Online ISBN: 978-3-540-89208-3

  • eBook Packages: EngineeringEngineering (R0)

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