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Simulation of tissue differentiation in a mechanically loaded bone regeneration chamber

  • Hanifeh KhayyeriEmail author
  • S. Checa
  • M. Tagil
  • P. J. Prendergast
Part of the IFMBE Proceedings book series (IFMBE, volume 22)

Abstract

Tissue differentiation can be regulated by mechanical loading. A bone chamber experiment has been conducted in order to investigate the effect of loading on tissue differentiation in vivo. In this study a computational model of the experiment was developed in which a mechano-regulation algorithm for stem cell differentiation in response to mechanical stimulus was combined with algorithms for cell migration, proliferation and apoptosis. The results show that the simulation is feasible to forecast the tissue differentiation process inside a bone chamber.

Keywords

tissue differentiation bone chamber mechano-regulation finite element model numerical simulation 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Hanifeh Khayyeri
    • 1
    Email author
  • S. Checa
    • 1
  • M. Tagil
    • 2
  • P. J. Prendergast
    • 1
  1. 1.Trinity Centre for BioengineeringSchool of Engineering, Trinity CollegeDublinIreland
  2. 2.Department of OrthopedicsLund University HospitalLundSweden

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