Skip to main content
SpringerLink
Log in
Book cover

Obstetric Dermatology pp 63–75Cite as

Autoimmune Conditions During Pregnancy

  • Chapter

  • 1188 Accesses

Systemic lupus erythematosus (SLE) is a relatively common disease, with an incidence of approximately one per 1,000 women [41]. The mean onset of disease is about 30 years of age [15]; therefore, it is not surprising that SLE and pregnancy may occur coincidentally together, and indeed lupus is seen in approximately one of every 1,660 pregnancies [45].

There is an abundance of material published on SLE in pregnancy; however, despite this vast amount of literature, there is no agreement regarding the effects of pregnancy on SLE clinical manifestations, or whether there are adverse effects of SLE on fetal or maternal outcome [15].

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Fine LG, Barnett E V, Danovitch GM et al (1981) Systemic lupus erythematosus in pregnancy. Ann Intern Med 94:667–677

    Google Scholar 

  2. Anhalt GJ (1999) Making sense of antigens and antibodies in pemphigus. J Am Acad Dermatol 40:763–766

    Article  PubMed  CAS  Google Scholar 

  3. Artlett CM (2003) Microchimerism and scleroderma: an update. Curr Rheumatol Rep 5:154–159

    Article  PubMed  Google Scholar 

  4. Ballou S P, Morley JJ, Kushner I (1984) Pregnancy and systemic sclerosis. Arthritis Rheum 27:295–298

    Article  PubMed  CAS  Google Scholar 

  5. Beck JS, Oakley CL, Rowell NR (1966) Transplacental passage of antinuclear antibody. Study in infants of mothers with systemic lupus erythematosus. Arch Dermatol 93:656–663

    Article  PubMed  CAS  Google Scholar 

  6. Black CM, Stevens WM (1989) Scleroderma. Rheum Dis Clin North Am 15:193–212

    PubMed  CAS  Google Scholar 

  7. Branch DW, Khamashta MA (2003) Antiphospholipid syndrome: obstetric diagnosis, management, and controversies. Obstet Gynecol 101:1333–1344

    Article  PubMed  Google Scholar 

  8. Brown AN, Bolster MB (2003) Scleroderma renal crisis in pregnancy associated with massive proteinuria. Clin Exp Rheumatol 21:114–116

    PubMed  CAS  Google Scholar 

  9. Buyon JP (1998) The effects of pregnancy on autoimmune diseases. J Leukoc Biol 63:281–287

    PubMed  CAS  Google Scholar 

  10. Chowdhury MM, Natarajan S (1998) Neonatal pemphigus vulgaris associated with mild oral pemphigus vulgaris in the mother during pregnancy. Br J Dermatol 139:500–503

    Article  PubMed  CAS  Google Scholar 

  11. Chung L, Lin J, Furst DE et al (2006) Systemic and localized scleroderma. Clin Dermatol 24:374–392

    Article  PubMed  Google Scholar 

  12. Clowse ME, Magder LS, Witter F et al (2005) The impact of increased lupus activity on obstetric outcomes. Arthritis Rheum 52:514–521

    Article  PubMed  Google Scholar 

  13. Devoe LD, Taylor RL (1979) Systemic lupus erythematosus in pregnancy. Am J Obstet Gyne-col 135:473–479

    CAS  Google Scholar 

  14. Dhar J P, Sokol RJ (2006) Lupus and pregnancy: complex yet manageable. Clin Med Res 4:310–321

    Article  PubMed  Google Scholar 

  15. Eudy SF, Baker GF (1990) Dermatopathology for the obstetrician. Clin Obstet Gynecol 33:728–737

    Article  PubMed  CAS  Google Scholar 

  16. Eyre RW, Stanley JR (1988) Maternal pemphigus foliaceus with cell surface antibody bound in neonatal epidermis. Arch Dermatol 124:25–27

    Article  PubMed  CAS  Google Scholar 

  17. Frances C, Piette JC (1997) Cutaneous manifestations of Hughes syndrome occurring in the context of lupus erythematosus. Lupus 6:139–144

    Article  PubMed  CAS  Google Scholar 

  18. Ginsberg JS, Bates SM (2003) Management of venous thromboembolism during pregnancy. J Thromb Haemost 1:1435–1442

    Article  PubMed  CAS  Google Scholar 

  19. Goldberg NS, DeFeo C, Kirshenbaum N (1993) Pemphigus vulgaris and pregnancy: risk factors and recommendations. J Am Acad Dermatol 28:877–879

    Article  PubMed  CAS  Google Scholar 

  20. Gordon C (2004) Pregnancy and autoimmune diseases. Best Pract Res Clin Rheumatol 18:359–379

    PubMed  CAS  Google Scholar 

  21. Green D, Maize JC (1982) Maternal pemphigus vulgaris with in vivo bound antibodies in the stillborn fetus. J Am Acad Dermatol 7:388–392

    Article  PubMed  CAS  Google Scholar 

  22. Gutierrez G, Dagnino R, Mintz G (1984) Polymyositis/dermatomyositis and pregnancy. Arthritis Rheum 27:291–294

    Article  PubMed  CAS  Google Scholar 

  23. Hayslett J P, Reece EA (1985) Systemic lupus erythematosus in pregnancy. Clin Perinatol 12:539–550

    PubMed  CAS  Google Scholar 

  24. Hellreich P (1974) The skin changes of pregnancy. Cutis 13:82–86

    Google Scholar 

  25. Hern S, Vaughan Jones SA, Setterfield J et al (1998) Pemphigus vulgaris in pregnancy with favourable foetal prognosis. Clin Exp Dermatol 23:260–263

    Article  PubMed  CAS  Google Scholar 

  26. Hirsch R, Anderson J, Weinberg JM et al (2003) Neonatal pemphigus foliaceus. J Am Acad Dermatol 49:S187–189

    Article  PubMed  Google Scholar 

  27. Honeyman JF, Eguiguren G, Pinto A et al (1981) Bullous dermatoses of pregnancy. Arch Dermatol 117:264–267

    Article  PubMed  CAS  Google Scholar 

  28. Imbasciati E, Surian M, Bottino S et al (1984) Lupus nephropathy and pregnancy. A study of 26 pregnancies in patients with systemic lupus erythematosus and nephritis. Nephron 36:46–51

    Article  PubMed  CAS  Google Scholar 

  29. Johnson MJ, Petri M, Witter FR et al (1995) Evaluation of preterm delivery in a systemic lupus erythematosus pregnancy clinic. Obstet Gynecol 86:396–399

    Article  PubMed  CAS  Google Scholar 

  30. Johnson TR, Banner EA, Winkelmann RK (1964) Scleroderma and pregnancy. Obstet Gynecol 23:467–469

    PubMed  CAS  Google Scholar 

  31. Karlen JR, Cook WA (1974) Renal scleroderma and pregnancy. Obstet Gynecol 44:349–354

    PubMed  CAS  Google Scholar 

  32. Khamashta MA, Hughes GR (1996) Pregnancy in systemic lupus erythematosus. Curr Opin Rheumatol 8:424–429

    Article  PubMed  CAS  Google Scholar 

  33. Khamashta MA, Ruiz-Irastorza G, Hughes GR (1997) Systemic lupus erythematosus flares during pregnancy. Rheum Dis Clin North Am 23:15–30

    Article  PubMed  CAS  Google Scholar 

  34. King CR, Chow S (1985) Dermatomyositis and pregnancy. Obstet Gynecol 66:589–592

    PubMed  CAS  Google Scholar 

  35. Lavery JP (1981) Teratology for the dermatologist. Int J Dermatol 20:272–274

    Article  PubMed  CAS  Google Scholar 

  36. Lee LA, Lillis PJ, Fritz KA et al (1983) Neonatal lupus syndrome in successive pregnancies. J Am Acad Dermatol 9:401–406

    Article  PubMed  CAS  Google Scholar 

  37. Leinwand I, Duryee AW, Richter MN (1954) Scleroderma; based on a study of over 150 cases. Ann Intern Med 41:1003–1041

    PubMed  CAS  Google Scholar 

  38. Lockshin MD (1985) Lupus pregnancy. Clin Rheum Dis 11:611–632

    PubMed  CAS  Google Scholar 

  39. McCuiston C, Schoch E (1954) Possible discoid lupus erythematosus in a newborn infant: Report of a case with subsequent development of acute systemic lupus erythematosus in mother. Arch Dermatol 70:782–785

    Google Scholar 

  40. McKenzie AW (1971) Skin disorders in pregnancy. Practitioner 206:773–780

    PubMed  CAS  Google Scholar 

  41. Mecacci F, Pieralli A, Bianchi B et al (2007) The impact of autoimmune disorders and adverse pregnancy outcome. Semin Perinatol 31:223–226

    Article  PubMed  Google Scholar 

  42. Mok CC, Kwan TH, Chow L (2003) Scleroderma renal crisis sine scleroderma during pregnancy. Scand J Rheumatol 32:55–57

    Article  PubMed  CAS  Google Scholar 

  43. Molad Y, Borkowski T, Monselise A et al (2005) Maternal and fetal outcome of lupus pregnancy: a prospective study of 29 pregnancies. Lupus 14:145–151

    Article  PubMed  CAS  Google Scholar 

  44. Moncada B, Kettelsen S, Hernandez-Moctezuma JL et al (1982) Neonatal pemphigus vulgaris: role of passively transferred pemphigus antibodies. Br J Dermatol 106:465–467

    Article  PubMed  CAS  Google Scholar 

  45. Mor-Yosef S, Navot D, Rabinowitz R et al (1984) Collagen diseases in pregnancy. Obstet Gynecol Surv 39:67–84

    Article  PubMed  CAS  Google Scholar 

  46. Muhammad JK, Lewis MA, Crean SJ (2002) Oral pemphigus vulgaris occurring during pregnancy. J Oral Pathol Med 31:121–124

    PubMed  Google Scholar 

  47. Nelson JL (2003) Microchimerism in human health and disease. Autoimmunity 36:5–9

    Article  PubMed  CAS  Google Scholar 

  48. Petri M (1998) Pregnancy in SLE. Baillieres Clin Rheumatol 12:449–476

    Article  PubMed  CAS  Google Scholar 

  49. Pisa FE, Bovenzi M, Romeo L et al (2002) Reproductive factors and the risk of scleroderma: an Italian case-control study. Arthritis Rheum 46:451–456

    Article  PubMed  Google Scholar 

  50. Rocha-Alvarez R, Friedman H, Campbell IT et al (1992) Pregnant women with endemic pemphigus foliaceus (fogo selvagem) give birth to disease-free babies. J Invest Dermatol 99:78–82

    Article  PubMed  CAS  Google Scholar 

  51. Ross MG, Kane B, Frieder R et al (1986) Pemphigus in pregnancy: a reevaluation of fetal risk. Am J Obstet Gynecol 155:30–33

    PubMed  CAS  Google Scholar 

  52. Ruach M, Ohel G, Rahav D et al (1995) Pemphigus vulgaris and pregnancy. Obstet Gynecol Surv 50:755–760

    Article  PubMed  CAS  Google Scholar 

  53. Ruiz-Irastorza G, Lima F, Alves J et al (1996) Increased rate of lupus flare during pregnancy and the puerperium: a prospective study of 78 pregnancies. Br J Rheumatol 35:133–138

    Article  PubMed  CAS  Google Scholar 

  54. Scarpinato L, Mackenzie AH (1985) Pregnancy and progressive systemic sclerosis. Case report and review of the literature. Cleve Clin Q 52:207–211

    PubMed  CAS  Google Scholar 

  55. Shieh S, Fang Y V, Becker JL et al (2004) Pemphigus, pregnancy, and plasmapheresis. Cutis 73:327–329

    PubMed  Google Scholar 

  56. Silman AJ, Black C (1988) Increased incidence of spontaneous abortion and infertility in women with scleroderma before disease onset: a controlled study. Ann Rheum Dis 47:441–444

    Article  PubMed  CAS  Google Scholar 

  57. Slate WG, Graham AR (1968) Scleroderma and pregnancy. Am J Obstet Gynecol 101:335–341

    PubMed  CAS  Google Scholar 

  58. Steen VD (1997) Scleroderma and pregnancy. Rheum Dis Clin North Am 23:133–147

    Article  PubMed  CAS  Google Scholar 

  59. Steen VD (1999) Pregnancy in women with systemic sclerosis. Obstet Gynecol 94:15–20

    Article  PubMed  CAS  Google Scholar 

  60. Steen VD, Medsger TA Jr (1999) Fertility and pregnancy outcome in women with systemic sclerosis. Arthritis Rheum 42:763–768

    Article  PubMed  CAS  Google Scholar 

  61. Steen VD, Conte C, Day N et al (1989) Pregnancy in women with systemic sclerosis. Arthritis Rheum 32:151–157

    Article  PubMed  CAS  Google Scholar 

  62. Storer JS, Galen WK, Nesbitt LT Jr et al (1982) Neonatal pemphigus vulgaris. J Am Acad Dermatol 6:929–932

    Article  PubMed  CAS  Google Scholar 

  63. Swinburne LM (1970) Leucocyte antigens and placental sponge. Lancet 2:592–594

    Article  PubMed  CAS  Google Scholar 

  64. Syrop CH, Varner MW (1983) Systemic lupus erythematosus. Clin Obstet Gynecol 26:547–557

    Article  PubMed  CAS  Google Scholar 

  65. Terpstra H, de Jong MC, Klokke AH (1979) In vivo bound pemphigus antibodies in a stillborn infant. Passive intrauterine transfer of pemphigus vulgaris? Arch Dermatol 115:316–319

    Article  PubMed  CAS  Google Scholar 

  66. Tope WD, Kamino H, Briggaman RA et al (1993) Neonatal pemphigus vulgaris in a child born to a woman in remission. J Am Acad Dermatol 29:480–485

    Article  PubMed  CAS  Google Scholar 

  67. Torgerson RR, Marnach ML, Bruce AJ et al (2006) Oral and vulvar changes in pregnancy. Clin Dermatol 24:122–132

    Article  PubMed  Google Scholar 

  68. Tsai A, Lindheimer MD, Lamberg SI (1973) Dermatomyositis complicating pregnancy. Obstet Gynecol 41:570–573

    PubMed  CAS  Google Scholar 

  69. Tseng CE, Buyon JP (1997) Neonatal lupus syndromes. Rheum Dis Clin North Am 23:31–54

    Article  PubMed  CAS  Google Scholar 

  70. Urowitz MB, Gladman DD, Farewell VT et al (1993) Lupus and pregnancy studies. Arthritis Rheum 36:1392–1397

    Article  PubMed  CAS  Google Scholar 

  71. Vaughan Jones SA, Black MM (1999) Pregnancy dermatoses. J Am Acad Dermatol 40:233–241

    Article  PubMed  CAS  Google Scholar 

  72. Walker DC, Kolar KA, Hebert AA et al (1995) Neonatal pemphigus foliaceus. Arch Dermatol 131:1308–1311

    Article  PubMed  CAS  Google Scholar 

  73. Wasserstrum N, Laros RK Jr (1983) Transplacental transmission of pemphigus. JAMA 249:1480–1482

    Article  PubMed  CAS  Google Scholar 

  74. Watson RM, Lane AT, Barnett NK et al (1984) Neonatal lupus erythematosus. A clinical, serological and immunogenetic study with review of the literature. Medicine (Baltimore) 63:362–378

    CAS  Google Scholar 

  75. 75.Winton GB (1989) Skin diseases aggravated by pregnancy. J Am Acad Dermatol 20:1–13

    Article  PubMed  CAS  Google Scholar 

  76. Winton GB, Lewis CW (1982) Dermatoses of pregnancy. J Am Acad Dermatol 6:977–998

    Article  PubMed  CAS  Google Scholar 

  77. Wu H, Wang ZH, Ya n A et al (2000) Protection against pemphigus foliaceus by desmoglein 3 in neonates. N Engl J Med 343:31–35

    Article  PubMed  CAS  Google Scholar 

  78. Yell JA, Burge SM (1993) The effect of hormonal changes on cutaneous disease in lupus ery-thematosus. Br J Dermatol 129:18–22

    Article  PubMed  CAS  Google Scholar 

Download references

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

(2009). Autoimmune Conditions During Pregnancy. In: Obstetric Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-88399-9_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-88399-9_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-88398-2

  • Online ISBN: 978-3-540-88399-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation