Almost all women, presumably up to 90%, and particularly those with dark hair and complexions, note some degree of hyperpigmentation during pregnancy. Patients are often deeply concerned by this condition, and may view these changes with uneasiness, yet hardly ever do they voluntarily express their concerns [21].
There is usually a mild generalized pigmentation, most marked in areas that are already slightly darker than surrounding skin, such as the nipples, areola, neck, upper back, periumbilical skin, and midline of the abdomen (Figs. 2.1–2.3). Other areas that may perceptibly darken are areas of friction such as the medial thighs, the perineum, and the axillae. In addition, freckles, nevi, and recent scars may darken and even enlarge during gestation [1]. Generalized hypermelanosis may rarely develop, and its occurrence suggests hyperthyroidism [11].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Barankin B, Silver SG, Carruthers A (2002) The skin in pregnancy. J Cutan Med Surg 6:236–240
Beischer NA, Wein P (1996) Linea alba pigmentation and umbilical deviation in nulliparous pregnancy: the ligamentum teres sign. Obstet Gynecol 87:254–256
Clark D, Thody AJ, Shuster S et al (1978) Immunoreactive alpha-MSH in human plasma in pregnancy. Nature 273:163–164
Dahlberg BC (1961) Melanocyte stimulating substances in the urine of pregnant women. Acta Endocrinol Suppl (Copenh) 38(Suppl 60):1–51
Elling S V, Powell FC (1997) Physiological changes in the skin during pregnancy. Clin Dermatol 15:35–43
Ellis DL, Wheeland RG (1986) Increased nevus estrogen and progesterone ligand binding related to oral contraceptives or pregnancy. J Am Acad Dermatol 14:25–31
Errickson C V, Matus NR (1994) Skin disorders of pregnancy. Am Fam Physician 49:605–610
Eudy SF, Baker GF (1990) Dermatopathology for the obstetrician. Clin Obstet Gynecol 33:728–737
Fryer JM, Werth VP (1992) Pregnancy-associated hyperpigmentation: longitudinal melanonychia. J Am Acad Dermatol 26:493–494
Grimes PE (1995) Melasma. Etiologic and therapeutic considerations. Arch Dermatol 131:1453–1457
Hellreich P (1974) The skin changes of pregnancy. Cutis 13:82–86
James WD, Meltzer MS, Guill MA et al (1984) Pigmentary demarcation lines associated with pregnancy. J Am Acad Dermatol 11:438–440
Katsambas A, Antoniou C (1995) Melasma. Classification and treatment. J Eur Acad Dermatol Venereol 4:217
Kligman AM, Willis I (1975) A new formula for depigmenting human skin. Arch Dermatol 111:40–48
Kumari R, Laxmisha C, Thappa DM (2006) Pigmentary demarcation lines associated with pregnancy. J Cosmet Dermatol 5:169–170
Kumari R, Jaisankar TJ, Thappa DM (2007) A clinical study of skin changes in pregnancy. Indian J Dermatol Venereol Leprol 73:141
Mallick S, Singh SK, Sarkar C et al (2005) Human placental lipid induces melanogenesis by increasing the expression of tyrosinase and its related proteins in vitro. Pigment Cell Res 18:25–33
Martin AG, Leal-Khouri S (1992) Physiologic skin changes associated with pregnancy. Int J Dermatol 31:375–378
McGuinness B (1963) Melanocyte-stimulating hormone. A clinical and laboratory study. Ann N Y Acad Sci 100:640–657
McKenzie AW (1971) Skin disorders in pregnancy. Practitioner 206:773–780
Muallem MM, Rubeiz NG (2006) Physiological and biological skin changes in pregnancy. Clin Dermatol 24:80–83
Murray JC (1990) Pregnancy and the skin. Dermatol Clin 8:327–334
Muzaffar F, Hussain I, Haroon TS (1998) Physiologic skin changes during pregnancy: a study of 140 cases. Int J Dermatol 37:429–431
Newcomer VD, Lindberg MC, Sternberg TH (1961) A melanosis of the face (“chloasma”). Arch Dermatol 83:284–299
Nussbaum R, Benedetto AV (2006) Cosmetic aspects of pregnancy. Clin Dermatol 24: 133–141
Ozawa H, Rokugo M, Aoyama H (1993) Pigmentary demarcation lines of pregnancy with erythema. Dermatology 187:134–136
Parmley T, O'Brien TJ (1990) Skin changes during pregnancy. Clin Obstet Gynecol 33: 713–717
Perez M, Sanchez JL, Aguilo F (1983) Endocrinologic profile of patients with idiopathic melasma. J Invest Dermatol 81:543–545
Raj S, Khopkar U, Kapasi A et al (1992) Skin in pregnancy. Indian Dermatol Venereol Leprol 58:84–88
Ranson M, Posen S, Mason RS (1988) Human melanocytes as a target tissue for hormones: in vitro studies with 1 alpha-25, dihydroxyvitamin D3, alpha-melanocyte stimulating hormone, and beta-estradiol. J Invest Dermatol 91:593–598
Rubin AI, Laborde S V, Stiller MJ (2001) Acquired dermal melanocytosis: appearance during pregnancy. J Am Acad Dermatol 45:609–613
Sanchez N P, Pathak MA, Sato S et al (1981) Melasma: a clinical, light microscopic, ultrastructural, and immunofluorescence study. J Am Acad Dermatol 4:698–710
Shizume K, Lerner AB (1954) Determination of melanocyte-stimulating hormone in urine and blood. J Clin Endocrinol Metab 14:1491–1510
Snell RS, Bischitz PG (1960) The effect of large doses of estrogen and estrogen and progesterone on melanin pigmentation. J Invest Dermatol 35:73–82
Szabo G (1954) The number of melanocytes in human epidermis. Br Med J 1:1016–1017
Thody AJ, Plummer NA, Burton JL et al (1974) Plasma beta-melanocyte-stimulating hormone levels in pregnancy. J Obstet Gynaecol Br Commonw 81:875–877
Vazquez M, Ibanez MI, Sanchez JL (1986) Pigmentary demarcation lines during pregnancy. Cutis 38:263–266
Wade TR, Wade SL, Jones HE (1978) Skin changes and diseases associated with pregnancy. Obstet Gynecol 52:233–242
Winton GB, Lewis CW (1982) Dermatoses of pregnancy. J Am Acad Dermatol 6:977–998
Wong RC, Ellis CN (1984) Physiologic skin changes in pregnancy. J Am Acad Dermatol 10:929–940
Wong RC, Ellis CN (1989) Physiologic skin changes in pregnancy. Semin Dermatol 8:7–11
Rights and permissions
Copyright information
© 2009 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
(2009). Hyperpigmentation and Melasma. In: Obstetric Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-88399-9_2
Download citation
DOI: https://doi.org/10.1007/978-3-540-88399-9_2
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-88398-2
Online ISBN: 978-3-540-88399-9
eBook Packages: MedicineMedicine (R0)