Posterior Pituitary Hormone, Diabetes Insipidus


  • Idiopathic diabetes insipidus is rarely connected to specific skin diseases. There are no specific cutaneous manifestations; only singular reports on allergic reactions caused by vasopressin preparations are available.

  • Langerhans cell histiocytosis (LCH) is associated in up to 50% of patients with diabetes insipidus. LCH is a clonal accumulation of specific cells resembling normal epidermal Langerhans cells. The skin lesions are agglomerated red or brown papules and tumours with ulceration and incrustation. Diagnosis requires pathohistological investigation, and the singular diagnostic feature is the presence of LCH cells. For treatment, chemotherapy or radiotherapy have been performed.


Diabetes Insipidus Nephrogenic Diabetes Insipidus Central Diabetes Insipidus Plasma Vasopressin Birbeck Granule 
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