Posterior Pituitary Hormone, Diabetes Insipidus
Idiopathic diabetes insipidus is rarely connected to specific skin diseases. There are no specific cutaneous manifestations; only singular reports on allergic reactions caused by vasopressin preparations are available.
Langerhans cell histiocytosis (LCH) is associated in up to 50% of patients with diabetes insipidus. LCH is a clonal accumulation of specific cells resembling normal epidermal Langerhans cells. The skin lesions are agglomerated red or brown papules and tumours with ulceration and incrustation. Diagnosis requires pathohistological investigation, and the singular diagnostic feature is the presence of LCH cells. For treatment, chemotherapy or radiotherapy have been performed.
KeywordsDiabetes Insipidus Nephrogenic Diabetes Insipidus Central Diabetes Insipidus Plasma Vasopressin Birbeck Granule
Unable to display preview. Download preview PDF.
- Donadieu J, Rolon MA, Thomas C, Brugieres L, Plantaz D, Emile J F, Frappaz D, David M, Brauner R, Genereau T, Debray D, Cabrol S, Barthez MA, Hoang-Xuan K, Polak M; French LCH Study Group. Endocrine involvement in pediatric-onset Langerhans' cell histiocytosis: a population-based study. J Pediatr. 2004;144(3):344–50.PubMedCrossRefGoogle Scholar
- Favara BE, Jaffe MB. The histopathology of Langerhans cell histiocytosis. Br J Cancer 1994;70(Suppl 23):S17–S23Google Scholar
- Kaltsas GA, Powles TB, Evanson J, Plowman PN, Drinkwater JE, Jenkins PJ, Monson J P, Besser GM, Grossman AB. Hypothalamo-pituitary abnormalities in adult patients with langerhans cell histiocytosis: clinical, endocrinological, and radiological features and response to treatment. J Clin Endocrinol Metab. 2000;85(4):1370–6.PubMedCrossRefGoogle Scholar
- Khiari K, Cherif L, Hadj Ali I, Turki S, Lakhoua Y, Ben Abdallah N, Ben Maiz H. Central diabetes insipidus with Behcet disease. A case report. Ann Endocrinol (Paris). 2003;64(6):426–7.Google Scholar
- Yokota M, Matsukura S, Kaji H, Taminato T, Fujita T. Allergic reaction to DDAVP (deamino arginin vasopressinin) in diabetes insipidus: successful treatment with its graded doses. Endo-crinol Jpn. 1982;29(4):475–7.Google Scholar