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An Evolutionary Study of the Human Papillomavirus Genomes

  • Conference paper
Comparative Genomics (RECOMB-CG 2008)

Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 5267))

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Abstract

In this article, we undertake a study of the evolution of Human Papillomaviruses (HPV), whose potential to cause cervical cancer is well known. First, we found that the existing HPV groups are monophyletic and that the high-risk carcinogenicity taxa are usually clustered together. Then, we present a new algorithm for analyzing the information content of multiple sequence alignments in relation to epidemiologic carcinogenicity data to identify regions that would warrant additional experimental analyses. The new algorithm is based on a sliding window procedure looking for genomic regions being responsible for disease. Examination of the genomes of 83 HPVs allowed us to identify specific regions that might be influenced by insertions, deletions, or simply by mutations, and that may be of interest for further analyses.

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Author information

Authors and Affiliations

  1. Département d’informatique, Université du Québec à Montréal, C.P. 8888, Succursale Centre-Ville, Montréal, (Québec), H3C 3P8, Canada

    Dunarel Badescu, Abdoulaye Baniré Diallo & Vladimir Makarenkov

  2. McGill Centre for Bioinformatics and School of Computer Science, McGill University, 3775 University Street, Montréal, Québec, H3A 2B4, Canada

    Abdoulaye Baniré Diallo & Mathieu Blanchette

Authors
  1. Dunarel Badescu
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  2. Abdoulaye Baniré Diallo
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  3. Mathieu Blanchette
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  4. Vladimir Makarenkov
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Editor information

Editors and Affiliations

  1. Molecular and Cell Biology, University of Connecticut, Division of Genetics and Genomics, Beach Hall, 354 Mansfiled Rd, CT 06269, Storrs, USA

    Craig E. Nelson

  2. Université Paris-Est, IGM-LabInfo, 5 Bd Descartes, Champs sur Marne, 77454, Marne la Vallée, France

    Stéphane Vialette

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© 2008 Springer-Verlag Berlin Heidelberg

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Badescu, D., Diallo, A.B., Blanchette, M., Makarenkov, V. (2008). An Evolutionary Study of the Human Papillomavirus Genomes. In: Nelson, C.E., Vialette, S. (eds) Comparative Genomics. RECOMB-CG 2008. Lecture Notes in Computer Science(), vol 5267. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-87989-3_10

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  • DOI: https://doi.org/10.1007/978-3-540-87989-3_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-87988-6

  • Online ISBN: 978-3-540-87989-3

  • eBook Packages: Computer ScienceComputer Science (R0)

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