Pharming pp 101-120

Part of the Ethics of Science and Technology Assessment book series (ETHICSSCI, volume 35) | Cite as

The welfare of pharming animals

  • Eckard Rehbinder
  • E. Rehbinder
  • M. Engelhard
  • K. Hagen
  • R. B. Jørgensen
  • R. Pardo-Avellaneda
  • A. Schnieke
  • F. Thiele

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Boivin J, Takefman JE (1996) Impact of in-vitro fertilization process on emotional, physical and relational variables. Human Reprod 11:903–907Google Scholar
  2. Brem G, Kuhholzer B (2002) The recent history of somatic cloning in mammals. Cloning Stem Cells 1:57–63CrossRefGoogle Scholar
  3. Broom DM (1991) Animal welfare concepts and measurement. J Anim Sci 69:4167–4175PubMedGoogle Scholar
  4. Broom DM, Johnson KG (1993) Stress and Animal Welfare. Chapman and Hall, LondonGoogle Scholar
  5. Canadian Council on Animal Care (1997) Canadian Council on Animal Care (CCAC) Guidelines on Transgenic Animals http://www.ccac.ca/en/CCAC_Programs/Guidelines_Policies/GDLINES/ TRANSGEN/TRANSGE1.HTM (April 2008)
  6. Chavatte-Palmer P, Heyman Y, Richard C, Monget P, LeBourhis D, Kann G, Chilliard Y, Vignon X, Renard JP (2002) Clinical, hormonal, and hematologic characteristics of bovine calves derived from nuclei from somatic cells. Biol Reprod 66:1596–1603PubMedCrossRefGoogle Scholar
  7. Chavatte-Palmer P, Remy D, Cordonnier N, Richard C, Issenmann H, Laigre P, Heyman Y, Mialot JP (2004) Health status of cattle at different ages. Cloning Stem Cells 6:94–100PubMedCrossRefGoogle Scholar
  8. Costa P (1997) Production of transgenic animals: practical problems and welfare aspects. In: van Zutphen LFM, van der Meer M (eds) Welfare aspects of transgenic animals. Springer, Berlin, pp 68–77Google Scholar
  9. Dawkins MS (1980) Animal suffering: the science of animal welfare. Chapman and Hall, LondonGoogle Scholar
  10. Devinoy E, Stinnakre MG, Lavialle F, Thépot D, Ollivier-Bousquet M (1995) Intracellular routing and release of caseins and growth hormone produced into milk from transgenic mice. Experimental Cell Research 221:272–280PubMedCrossRefGoogle Scholar
  11. Duncan I (1993) Welfare is to do with what animals feel. J Ag & Appl Ethics 6:8–14Google Scholar
  12. Duncan I (2005) Science-based assessment of animal welfare: farm animals. Rev sci tech Off int Epiz 24:483–492Google Scholar
  13. Eaton M (2004) Ethics and the Business of Bioscience. Stanford University Press, StanfordGoogle Scholar
  14. Edwards JL, Schrick FN, McCracken MD, van Amstel SR, Hopkins FM, Welborn MG, Davies CJ (2003) Cloning adult farm animals: a review of the possibilities and problems associated with somatic cell nuclear transfer. Am J Reprod Immun 50:113–123CrossRefGoogle Scholar
  15. EFSA (2005) Aspects of the biology and welfare of animals used for experimental and other scientific purposes. EFSA-Q-2004-105. Annex to the European Food Safety Authority Journal 292:1–136Google Scholar
  16. EFSA (2006) Basic information for the development of the animal welfare risk assessment guidelines http://www.efsa.europa.eu/EFSA/DocumentSet/AHAW_report_basicinfo_AWRA_ en,0.pdf (June 2008)
  17. EFSA (2007) Opinion of the Scientific Panel on Animal Health and Welfare on a selfmandate on the Framework for EFSA AHAW Risk Assessments, The EFSA Journal 550:1–46 http://www.efsa.europa.eu/EFSA/Scientific_Opinion/ahaw_op_ej550_ framework_en,1.pdf (June 2008)
  18. Enright BP, Taneja M, Schreiber D, Riesen J, Tian XC, Fortune JE, Yang X (2002) Reproductive characteristics of cloned heifers derived from adult somatic cells. Biol Reprod 66:291–296PubMedCrossRefGoogle Scholar
  19. Fecteau ME, Palmer JE, Wilkins PA (2005) Neonatal care of high-risk cloned and transgenic calves. Vet Clin Food Anim 21:637–653CrossRefGoogle Scholar
  20. Fraser AF, Broom DM (1997) Farm animal behaviour and welfare. CAB InternationalGoogle Scholar
  21. Garry FB, Adams R, McCann JP, Odde KG (1996) Postnatal characteristics of calves produced by nuclear transfer cloning. Theriogenology 45:141–152CrossRefGoogle Scholar
  22. Gibbons J, Arat S, Rzucidlo J, Miyoshi K, Waltenburg R, Respess D, Venable A, Stice S (2002) Enhanced survivability of cloned calves derived from roscovitinetreated adult somatic cells. Biol Reprod 66:199–203CrossRefGoogle Scholar
  23. Govoni KE, Tian XC, Kazmer GW, Taneja M, Enright BP, Rivard AL, Yang X, Zinn SA (2002) Age-related changes of the somatotropic axis in cloned Holstein calves. Biol Reprod 66:291–296CrossRefGoogle Scholar
  24. Heyman Y, Richard C, Rodriguez-Martinez H, Lazzari G, Chavatte-Palmer P, Vignon X, Galli C (2004) Zootechnical performance of cloned cattle and offspring: preliminary results. Cloning Stem Cells 6:111–120PubMedCrossRefGoogle Scholar
  25. Hill JR, Roussel AJ, Cibelli JB, Edwards JF, Hooper NL, Miller MW, Thompson JA, Looney CR, Westhusin ME, Robl JM, Stice SL (1999) Clinical and pathological features of cloned transgenic calves and fetuses (13 case studies). Theriogenology 51:1451–1465PubMedCrossRefGoogle Scholar
  26. Institute of Laboratory Animal Research, Commission on Life Sciences, National Research Council (1996) Guide for the care and use of laboratory animals. National Acadamy PressGoogle Scholar
  27. Kaliste E (ed) (2004) The welfare of laboratory animals. Springer, BerlinGoogle Scholar
  28. Lanza RP, Cibelli JB, Faber D, Sweeney RW, Henderson B, Nevala W, West MD, Wettstein PJ (2001) Cloned cattle can be healthy and normal. Science 294:1893–1894PubMedCrossRefGoogle Scholar
  29. Li S, Li Y, Du W, Zhang L, Yu S, Dai Y, Zhao C, Li N (2005) Aberrant gene expression in organs of bovine clones that die within two days after birth. Biol Reprod 72:258–265PubMedCrossRefGoogle Scholar
  30. Lubon H (1998) Transgenic animal bioreactors in biotechnology and production of blood proteins. Biotechnol Annu Rev 4:1–54PubMedCrossRefGoogle Scholar
  31. MacKenzie AA (2005) Applications of genetic engineering for livestock and biotechnology products. World Organisation for Animal Health (OIE): 73 SG/10 http://www.oie.int/downld/SG/2005/A_73 {%}20SG_10.pdf (January 2007)
  32. Massoud M, Attal J, Thépot D, Pointu H, Stinnakre MG, Théron MC, Lopez C, Houdebine LM (1996) The deleterious effects of human erythropoietin gene driven by the rabbit whey acidic protein gene promoter in transgenic rabbits. Reprod Nutr Dev 36:555–563PubMedCrossRefGoogle Scholar
  33. Mertens C, Rülicke T (1999) Score sheets for the monitoring of transgenic mice. Animal Welfare 8:433–438Google Scholar
  34. Mertens C, Rülicke T (2000) Phenotype characterisation and welfare assessment of transgenic rodents (mice). Journal of Applied Animal Welfare Science 3:127–139CrossRefGoogle Scholar
  35. Mills AD, Beilharz RG, Hocking PM (1997) Genetic selection. In: Appleby MC, Hughes, BO (eds) Animal Welfare. CABI, pp 219–231Google Scholar
  36. Moberg GP, Mench JA (eds) (2000) The biology of animal stress: basic principles and implications for animal welfare. CABI, New YorkGoogle Scholar
  37. Müller-Graf C, Candiani D, Barbieri S, Ribó O, Afonso A, Aiassa E, Have P, Correia S, De Massis F, Grudnik T, Serratosa J (2007) Risk assessment in animal welfare – EFSA approach. Alternatives to Animal Testing and Experimentation 14, Special Issue:189–794 http://altweb.jhsph.edu/wc6/paper789.pdf (June 2008)
  38. Olsson IAS, Sandøe P (2004) Ethical decisions concerning animal biotechnology: what is the role of animal welfare science? Animal Welfare 13:139–144Google Scholar
  39. Pace MM, Augenstein ML, Betthauser JM, Childs LA, Eilertsen KJ, Enos JM, Forsberg EJ, Golueke PJ, Graber DF, Kemper JC, Koppang RW, Lange G, Lesmeister TL, Mallon KS, Mell GD, Misica PM, Pfister-Genskow M, Strelchenko NS, Voelker GR Watt SR, Bishop MD (2002) Ontongeny of cloned cattle to lactation. Biol Reprod 67:334–339PubMedCrossRefGoogle Scholar
  40. Panarace M, Agüero JI, Garrote M, Jauregui G, Segovia A, Cané L, Gutiérrez J, Marfil M, Rigali F, Pugliese M, Young S, Lagioia J, Garnil C, Forte Pontes JE, Ereno Junio JC, Mower S, Medina M (2006) How healthy are clones and their progeny: 5 years of field experience. Theriogenology 67:142–151PubMedCrossRefGoogle Scholar
  41. Perry GC (ed) (2004) Welfare of the Laying Hen (Poultry Science Symposium, No. 27). CABIGoogle Scholar
  42. Piedrahita JA, Wells DN, Miller AL, Oliver JE, Berg MC, Peterson AJ, Tervit HR (2002) Effects of follicular size of cytoplast donor on the efficiency of cloning in cattle. Mol Reprod Dev 61:317–326PubMedCrossRefGoogle Scholar
  43. Poole TB (ed) (1999) The UFAW Handbook on the Care and Management of Laboratory Animals. BlackwellGoogle Scholar
  44. Pursel VG, Pinkert CA, Miller KF, Bolt DJ, Campbell RG, Palmiter RD, Brinster RL, Hammer RE (1989) Genetic engineering of livestock. Science 244:1281–1288PubMedCrossRefGoogle Scholar
  45. Renard JP, Chastant S, Chesne P, Richard C, Marchal J, Cordonnier N, Chavatte P, Vignon X (1999) Lymphoid hypoplasia and somatic cloning. Lancet 353:1489–1491PubMedCrossRefGoogle Scholar
  46. Russell WMS, Burch RL (1959) The Principles of Humane Experimental Technique. Methuen & Co., LondonGoogle Scholar
  47. Sandøe P, Forsman B, Hansen AK (1997) Transgenic animals: the need for ethical dialogue. In: van Zutphen LFM, van der Meer M (eds) Welfare aspects of transgenic animals. Springer, Berlin, pp 90–101Google Scholar
  48. Schmitt EH (2004) Regulatory background in the development of medicinal products for human use produced by transgenic animals – current situation and perspective in the EU and USA. Wissenschaftliche Prüfungsarbeit zur Erlangung des Titels “Master of Drug Regulatory Affairs” der Rheinischen Friedrich-Wilhelms- Universitöt BonnGoogle Scholar
  49. Shamay A, Pursel VG, Wilkinson F, Wall RJ, Henninghausen L (1992) Expression of whey acidic protein in transgenic pigs impairs mammary development. Transgenic Research 1:124–132PubMedCrossRefGoogle Scholar
  50. Smith CP, Taylor V (eds) (1996) Environmental enrichment information resources for laboratory animals: 1965–1995. Birds, cats, dogs, farm animals, ferrets, rabbits, and rodents. Diane Publishing Company, DarbyGoogle Scholar
  51. Stolba A, Wood-Gush DGM (1984) The identification of behavioural key features and their incorporation into a housing design for pigs. Annales de Recherches Véterinaires 15:287–298PubMedGoogle Scholar
  52. Stolba A, Wood-Gush DGM (1989) The behaviour of pigs in a seminatural environment. Animal Production 48:419–425Google Scholar
  53. Ting CN, Kohrmann D, Burgess DL, Boyle A, Altschuler A, Gholizadeh G, Samuelson LC, Jang W, Meisler MH (1994) Insertional mutations of mouse chromosome 18 with vestibular and cranofacial abnormalities. Genetics 136:247–254PubMedGoogle Scholar
  54. Tsunoda Y, Kato Y (2002) Recent progress and problems in animal cloning. Differentiation 69:158–161PubMedCrossRefGoogle Scholar
  55. Van der Meer M, Rolls A, Baumans V, Olivier B, van Zutphen LFM (2001) Use of score sheets for welfare assessment of transgenic mice. Laboratory Animals 35:379–389PubMedCrossRefGoogle Scholar
  56. Van Reenen CG, Blokhuis HJ (1997) Evaluation of welfare of transgenic animals; lessons from a case study in cattle. In: Nilsson A (ed) Proc. transgenic animals and food production workshop, Stockholm, Sweden. J Royal Swedish Academy of Agriculture and Forestry 136:99–105Google Scholar
  57. Van Reenen CG, Meuwissen THE, Hopster H, Oldenbrock K, Kruip TAM, Blokhuis HJ (2001) Transgenesis may affect animal welfare: a case for systematic risk assessment. J Anim Sci 79:1763–1779PubMedGoogle Scholar
  58. Wall RJ, Rexroad CE, Powell A, Shamay A, McKnight R, Henninghausen L (1996) Synthesis and secretion of the mouse whey acidic protein in transgenic sheep. Transgenic Research 5:67–72PubMedCrossRefGoogle Scholar
  59. Weiher H, Nod T, Gray DA, Sharpe AH, Jaenisch R (1990) Transgenic mouse model of kidney disease: insertional inactivation of ubiquitously expressed gene leads to nephrotic syndrome. Cell 62:425–434PubMedCrossRefGoogle Scholar
  60. Wells DN, Wall RJ (1999) One gene is not enough. In: Murray JD, Anderson GB, Oberauer AM, McGloughlin MM (eds) Transgenic animals in agriculture. CABI, Oxon pp 37–56Google Scholar
  61. Wells DN, Forsyth JT, McMillan V, Oback B (2004) The health of somatic cell cloned cattle and their offspring. Cloning Stem Cells 2:101–110CrossRefGoogle Scholar
  62. Young LE, Sinclair KD, Wilmut I (1998) Large offspring syndrome in cattle and sheep. Rev Reprod 3:155–163PubMedCrossRefGoogle Scholar
  63. Young LE, Fairburn HR (2000) Improving the safety of embryo technologies: possible role of genomic imprinting. Theriogenology 53:627–648PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Eckard Rehbinder
    • 1
  • E. Rehbinder
  • M. Engelhard
  • K. Hagen
  • R. B. Jørgensen
  • R. Pardo-Avellaneda
  • A. Schnieke
  • F. Thiele
  1. 1.Johann Wolfgang Goethe-UniversitätGermany

Personalised recommendations