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Angiogenesis and Vasculogenesis in Multiple Myeloma: Role of Inflammatory Cells

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Multiple Myeloma

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 183))

Abstract

Angiogenesis plays a central role in the progression of both solid and hematologic tumors. We have focused our attention on multiple myeloma (MM) and on bone marrow stromal cells. These, in fact, both support tumor cell survival and participate in angiogenesis by releasing a broad number of angiogenic cytokines. Macrophages and mast cells may participate in this process through other mechanisms, such as vasculogenic mimicry. Lastly, it has been shown that hematopoietic stem and progenitor cells (HSPCs) are involved in vasculogenesis in MM.

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Acknowledgments

This work was supported in part by grants from Associazione Italiana per la Ricerca sul Cancro (AIRC), Milan; the Ministry of Education, University and Research (MIUR, PRIN Projects 2007), Rome; the Ministry of Health, Progetto Oncologia 2006, Rome; Humanitas Mirasole S.p.A., Rome; Fondazione Cassa di Risparmio di Puglia, Bari, Italy.

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Authors and Affiliations

  1. Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico – Piazza Giulio Cesare, 11, I-70124, Bari, Italy

    Angelo Vacca

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  1. Angelo Vacca
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  2. Domenico Ribatti
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Correspondence to Angelo Vacca .

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Editors and Affiliations

  1. Medizinische Klinik und Poliklinik, Abt. Hämatologie, Onkologie und, Universitätsklinikum Heidelberg, Hospitalstr. 3, Heidelberg, 69115, Germany

    Thomas Moehler

  2. Medizinische Klinik und Poliklinik, Abt. Innere Medizin V, Universitätsklinikum Heidelberg, Hospitalstr. 3, Heidelberg, 69115, Germany

    Hartmut Goldschmidt

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Vacca, A., Ribatti, D. (2011). Angiogenesis and Vasculogenesis in Multiple Myeloma: Role of Inflammatory Cells. In: Moehler, T., Goldschmidt, H. (eds) Multiple Myeloma. Recent Results in Cancer Research, vol 183. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85772-3_4

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  • DOI: https://doi.org/10.1007/978-3-540-85772-3_4

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-85771-6

  • Online ISBN: 978-3-540-85772-3

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