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Yanagida, M.: Cell cycle mechanisms of sister chromatid separation; roles of Cut1/separin and Cut2/securin. Genes Cells, 5, 1–8 (2000)
Sullivan, M.; Lehane, C.; Uhlmann, F.: Orchestrating anaphase and mitotic exit: separase cleavage and localization of Slk19. Nat. Cell Biol., 3, 771–777 (2001)
Amon, A.: Together until separin do us part. Nat. Cell Biol., 3, E12–14 (2001)
Siomos, M.F.; Badrinath, A.; Pasierbek, P.; Livingstone, D.; White, J.; Glotzer, M.; Nasmyth, K.: Separase is required for chromosome segregation during meiosis I in Caenorhabditis elegans. Curr. Biol., 11, 1825–1835 (2001)
Jager, H.; Herzig, A.; Lehner, C.F.; Heidmann, S.: Drosophila separase is required for sister chromatid separation and binds to PIM and THR. Genes Dev., 15, 2572–2584 (2001)
Hauf, S.; Waizenegger, I.C.; Peters, J.-M.: Cohesin cleavage by separase required for anaphase and cytokinesis in human cells. Science, 293, 1320–1323 (2001)
Ross, K.E.; Cohen-Fix, O.: Separase: a conserved protease separating more than just sisters. Trends Cell Biol., 12, 1–3 (2002)
Zou, H.; Stemman, O.; Anderson, J.S.; Mann, M.; Kirschner, M.W.: Anaphase specific auto-cleavage of separase. FEBS Lett., 528, 246–250 (2002)
Hornig, N.C.; Knowles, P.P.; McDonald, N.Q.; Uhlmann, F.: The dual mechanism of separase regulation by securin. Curr. Biol., 12, 973–982 (2002)
Waizenegger, I.C.; Gimenez-Abian, J.F.; Wernic, D.; Peters, J.-M.: Regulation of human separase by securin binding and autocleavage. Curr. Biol., 12, 1368–1378 (2002)
Stegmeier, F.; Visintin, R.; Amon, A.: Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase. Cell, 108, 207–220 (2002)
Buonomo, S.B.C.; Rabitsch, K.P.; Fuchs, J.; Gruber, S.; Sullivan, M.; Uhlmann, F.; Petronczki, M.; Toth, A.; Nasmyth, K.: Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19. Dev. Cell, 4, 727–739 (2003)
Sullivan, M.; Uhlmann, F.: A non-proteolytic function of separase links the onset of anaphase to mitotic exit. Nat. Cell Biol., 5, 249–254 (2003)
Chestukhin, A.; Pfeffer, C.; Milligan, S.; DeCaprio, J.A.; Pellman, D.: Processing, localization, and requirement of human separase for normal anaphase progression. Proc. Natl. Acad. Sci. USA, 100, 4574–4579 (2003)
Queralt, E.; Lehane, C.; Novak, B.; Uhlmann, F.: Downregulation of PP2A (Cdc55) phosphatase by separase initiates mitotic exit in budding yeast. Cell, 125, 719–732 (2006)
Kudo, N.R.; Wassmann, K.; Anger, M.; Schuh, M.; Wirth, K.G.; Xu, H.; Helmhart, W.; Kudo, H.; McKay, M.; Maro, B.; Ellenberg, J.; de Boer, P.; Nasmyth, K.: Resolution of chiasmata in oocytes requires separase-mediated proteolysis. Cell, 126, 135–146 (2006)
Gimenez-Abian, J.F.; Diaz-Martinez, L.A.; Waizenegger, I.C.; Gimenez-Martin, G.; Clarke, D.J.: Separase is required at multiple pre-anaphase cell cycle stages in human cells. Cell Cycle, 4, 1576–1584 (2005)
Kawasaki, Y.; Nagao, K.; Nakamura, T.; Yanagida, M.: Fission yeast MAP kinase is required for the increased securin-separase interaction that rescues separase mutants under stresses. Cell Cycle, 5, 1831–1839 (2006)
Fan, H.Y.; Sun, Q.Y.; Zou, H.: Regulation of Separase in meiosis: Separase is activated at the metaphase I–II transition in Xenopus oocytes during meiosis. Cell Cycle, 5, 198–204 (2006)
Terret, M.E.; Wassmann, K.; Waizenegger, I.; Maro, B.; Peters, J.M.; Verlhac, M.H.: The meiosis I-to-meiosis II transition in mouse oocytes requires separase activity. Curr. Biol., 13, 1797–1802 (2003)
Kitajima, T.S.; Miyazaki, Y.; Yamamoto, M.; Watanabe, Y.: Rec8 cleavage by separase is required for meiotic nuclear divisions in fission yeast. EMBO J., 22, 5643–5653 (2003)
Nagao, K.; Yanagida, M.: Securin can have a separase cleavage site by substitution mutations in the domain required for stabilization and inhibition of separase. Genes Cells, 11, 247–260 (2006)
Sullivan, M.; Hornig, N.C.; Porstmann, T.; Uhlmann, F.: Studies on substrate recognition by the budding yeast separase. J. Biol. Chem., 279, 1191–1196 (2004)
Wirth, K.G.; Wutz, G.; Kudo, N.R.; Desdouets, C.; Zetterberg, A.; Taghybeeglu, S.; Seznec, J.; Ducos, G.M.; Ricci, R.; Firnberg, N.; Peters, J.M.; Nasmyth, K.: Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression. J. Cell Biol., 172, 847–860 (2006)
Pandey, R.; Heidmann, S.; Lehner, C.F.: Epithelial re-organization and dynamics of progression through mitosis in Drosophila separase complex mutants. J. Cell Sci., 118, 733–742 (2005)
Ikai, N.; Yanagida, M.: Cdc48 is required for the stability of Cut1/separase in mitotic anaphase. J. Struct. Biol., 156, 50–61 (2006)
Gorr, I.H.; Boos, D.; Stemmann, O.: Mutual inhibition of separase and Cdk1 by two-step complex formation. Mol. Cell, 19, 135–141 (2005)
Papi, M.; Berdougo, E.; Randall, C.L.; Ganguly, S.; Jallepalli, P.V.: Multiple roles for separase auto-cleavage during the G2/M transition. Nat. Cell Biol., 7, 1029–1035 (2005)
Nagao, K.; Adachi, Y.; Yanagida, M.: Separase-mediated cleavage of cohesin at interphase is required for DNA repair. Nature, 430, 1044–1048 (2004)
Liu, Z.; Makaroff, C.A.: Arabidopsis separase AESP is essential for embryo development and the release of cohesin during meiosis. Plant Cell, 18, 1213–1225 (2006)
Pereira, G.; Schiebel, E.: Separase regulates INCENP-Aurora B anaphase spindle function through Cdc14. Science, 302, 2120–2124 (2003)
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(2009). Separase. In: Chang, A. (eds) Class 3 Hydrolases. Springer Handbook of Enzymes, vol S6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85705-1_3
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DOI: https://doi.org/10.1007/978-3-540-85705-1_3
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