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A Method for Semi-automatic Standard Integration in Systems Biology

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Database and Expert Systems Applications (DEXA 2008)

Part of the book series: Lecture Notes in Computer Science ((LNISA,volume 5181))

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Abstract

The development of standards for biological pathways has led to a huge amount of model data stored in a variety of different formats represented in XML (e.g. SBML) or OWL (e.g. BioPAX). There is an urgent need for the conversion of data between the formats, but the fact that the transformation is hard to realize hampers the integration of data in the area. This article proposes a general, semi-automatic solution by transforming XML Schema based data into an OWL format. Biologists will be supported in querying data of any format and comparing different data files or schemas to each other using OWL as a common format for matching. Additionally, a backwards transformation to XML Schema is provided. The paper presents a first architectural approach and its prototype implementation. The evaluation showed that the approach is promising.

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References

  1. Aumueller, D., Do, H.-H., et al.: Schema and ontology matching with coma. In: Proceedings of the 2005 ACM SIGMOD international conference on Management of data, June 2005, pp. 906–908. SIGMOD, ACM Press, New York (2005)

    Chapter  Google Scholar 

  2. Bohring, H., Auer, S.: Mapping xml to owl ontologies. In: Proceedings of the 13. Leipziger Informatik-Tage, vol. 72, pp. 147–156 (2005)

    Google Scholar 

  3. Brischniz: The xml2owl demonstration platform (last checked: 2008-06-10), http://xml2owl.sourceforge.net/

  4. Collins, F.S., Green, E.D., et al.: A vision for the future of genomics research. Nature 422, 835–847 (2003)

    Article  Google Scholar 

  5. Davidson, S., Overton, C.G., et al.: Challenges in integrating biological data sources. Journal of Computational Biology 2(4), 557–572 (1995)

    Article  Google Scholar 

  6. Doan, A., Halevy, A.: Semantic integration research in the database community: A brief survey. AI Magazine 26 (March 2005)

    Google Scholar 

  7. Ferdinand, M., Zirpins, C., et al.: Lifting xml schema to owl. In: Web Engineering - 4th International Conference, ICME 2004, pp. 354–358. Springer, Heidelberg (2004)

    Google Scholar 

  8. Gibbons, F.: The psi mi to biopax converter approach, from an email-conversation (last checked 2008-06-10) (May 2006), http://llama.med.harvard.edu/~fgibbons

  9. Hermjakob, H., Montecchi-Palazzi, L., et al.: The hupo psi’s molecular interaction format - a community standard for the representation of protein interaction data. Nature Biotechnology 22(2), 177–183 (2004)

    Article  Google Scholar 

  10. Joshi-Tope, G., Gillespie, M., et al.: Reactome: a knowledgebase of biological pathways. Nucleic Acids Research 33, D428-D432 (2005)

    Article  Google Scholar 

  11. Shengping, L., Jing, M., et al.: Xsdl: Making xml semantics explicit. In: Bussler, C.J., Tannen, V., Fundulaki, I. (eds.) SWDB 2004. LNCS, vol. 3372, pp. 64–83. Springer, Heidelberg (2005)

    Google Scholar 

  12. Lambrix, P.: Ontologies in Bioinformatics and Systems Biology. In: Artificial Intelligence Methods and Tools for Systems Biology, October 2005. Computational Biology, vol. 5, pp. 129–147. Springer, Heidelberg (2005)

    Google Scholar 

  13. Lambrix, P., He, T.: Sambo -a system for aligning and merging biomedical ontologies. Journal of Web Semantics, Special issue on Semantic Web for the Life Sciences 4, 196–206 (2006)

    Google Scholar 

  14. Fridman Noy, N.: PROMPT (last checked 2008-06-10) (2000), http://protege.stanford.edu/plugins/prompt/prompt.html

  15. Rahm, E., Bernstein, P.A.: A survey of approaches to automatic schema matching. The VLDB Journal 10, 334–350 (2001)

    Article  MATH  Google Scholar 

  16. Reif, G.: The weesa project (last checked 2008-06-10) (2005), http://www.infosys.tuwien.ac.at/weesa/

  17. Rübenacker, O., Moraru, I., et al.: Kinetic modeling using biopax ontology. In: IEEE International Conference on Bioinformatics and Biomedicine, pp. 339–348 (2007)

    Google Scholar 

  18. Strömbäck, L., Hall, D., et al.: A review of standards for data exchange within systems biology. Proteomics 7(6), 857–867 (2007)

    Article  Google Scholar 

  19. Uhrmacher, A.M., Rolfs, A., et al.: Dfg research training group 1387/1: diem osiris - integrative development of modelling and simulation methods for regenerative systems. it - Information Technology 49(6), 388–395 (2007)

    Article  Google Scholar 

  20. W3C. Extensible Markup Language (1999), http://www.w3.org/XML

  21. W3C. XML Path Language (November 1999), http://www.w3.org/TR/XPath

  22. W3C. Xml schema (May 2001), http://www.w3.org/XML/Schema

  23. W3C. Web Ontology Language (2004), http://www.w3.org/2004/OWL/

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Sourav S. Bhowmick Josef Küng Roland Wagner

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Köhn, D., Strömbäck, L. (2008). A Method for Semi-automatic Standard Integration in Systems Biology. In: Bhowmick, S.S., Küng, J., Wagner, R. (eds) Database and Expert Systems Applications. DEXA 2008. Lecture Notes in Computer Science, vol 5181. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85654-2_66

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  • DOI: https://doi.org/10.1007/978-3-540-85654-2_66

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-85653-5

  • Online ISBN: 978-3-540-85654-2

  • eBook Packages: Computer ScienceComputer Science (R0)

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