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Microbial Megaplasmids pp 311–325Cite as

Megaplasmid pMP118 of Lactobacillus salivarius

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Part of the book series: Microbiology Monographs ((MICROMONO,volume 11))

Abstract

Lactobacillus salivarius UCC118 habours a multiple-replicon genome, including a 242 kb megaplasmid designated pMP118. pMP118 carries a number of contingency genes, which work in conjunction with chromosomally encoded genes and pathways to broaden the metabolic flexibility of this strain. This increases the potential viability of UCC118 in the competitive environment of the gastrointestinal tract. Annotation and functional studies have indicated that pMP118 contributes significantly to the probiotic properties of UCC118, encoding a bile salt hydrolase gene and a potent broad-spectrum bacteriocin. pMP118-related megaplasmids have been established as a general feature of the species Lactobacillus salivarius. Megaplasmids have also been identified in six other Lactobacillus species of intestinal origin. Dissemination of the pMP118-related megaplasmids may have occurred by a conjugation apparatus, which is now non-functional in pMP118. The analysis of pMP118 highlights the contribution of this replicon to the biology and ecology of this commensal species.

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Acknowledgments

Work in PWOT's laboratory is supported by Science Foundation Ireland (CSET and RFP programmes).

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Authors and Affiliations

  1. Department of Microbiology & Alimentary Pharmabiotic Centre, University College Cork, Ireland

    Paul W. O'Toole & Emma J. Raftis

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  1. Paul W. O'Toole
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  2. Emma J. Raftis
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Editors and Affiliations

  1. Institut fuer Biologie, Mikrobiologie, Humboldt-Universität zu Berlin, Chausseestr. 117, Berlin, 10115, Germany

    Edward Schwartz

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O'Toole, P.W., Raftis, E.J. (2009). Megaplasmid pMP118 of Lactobacillus salivarius . In: Schwartz, E. (eds) Microbial Megaplasmids. Microbiology Monographs, vol 11. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85467-8_15

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