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Intraepithelial Neoplasia of the Digestive Tract

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Intraepithelial Neoplasia

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Abstract

The development of oral squamous cell carcinoma is a process similar to cervical intraepithelial neoplasia. Oral intraepithelial neoplasia (OIN) is not only a change in terminology but also represents substantial progress in unifying the definition of precancerous lesions. Oral precancerous lesions are clinically classified as leukoplakia, erythroplakia and erythroleukoplakia which are histologically classified as simple hyperplasia, squamous oral intraepithelial neoplasia (OIN-I, OIN-II, OIN-III) and invasive carcinoma. Nearly all cases of esophageal carcinoma develop from intraepithelial neoplasia. Esophageal intraepithelial neoplasia includes squamous and columnar (Barrett’s esophagus) types. Barrett’s esophagus is the most important precursor lesion of esophagus adenocarcinoma. Gastric intraepithelial neoplasia (dysplasia) arises from either the native (normal) gastric epithelium or intestinalized gastric epithelium. Colorectal intraepithelial neoplasia can be categorized as low-and high-grade. Low-grade intraepithelial neoplasia is a mild epithelial disorder. High-grade intraepithelial neoplasia is characterized by cytological and histological features of malignancy in mucosal epithelium without definite evidence of stromal invasion.

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Author information

Authors and Affiliations

  1. Department of Pathology, School of Medicine, Zhejiang University, China

    Maode Lai M.D. & Jian Chen PhD.

  2. Department of Pathology, Zhejiang Provincial Hospital, China

    Zhongsheng Zhao M.D.

Authors
  1. Maode Lai M.D.
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  2. Zhongsheng Zhao M.D.
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  3. Jian Chen PhD.
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Editors and Affiliations

  1. School of Medicine, Zhejiang University, 310058, Hangzhou, China

    Maode Lai

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© 2009 Higher Education Press, Beijing and Springer-Verlag GmbH Berlin Heidelberg

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Lai, M., Zhao, Z., Chen, J. (2009). Intraepithelial Neoplasia of the Digestive Tract. In: Lai, M. (eds) Intraepithelial Neoplasia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85453-1_2

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  • DOI: https://doi.org/10.1007/978-3-540-85453-1_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-85452-4

  • Online ISBN: 978-3-540-85453-1

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