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Intraepithelial Neoplasia of the Respiratory Tract

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Book cover Intraepithelial Neoplasia

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Abstract

Leukoplasia, squamous epithelial dysplasia and inverted papilloma are the common forms of upper respiratory tract intraepithelial neoplasia. All three lesions are frequently present before the development of carcinoma; Squamous epithelial dysplasia usually has no characteristic clinical features and is only identified in histological sections. Leukoplasia and inverted papilloma, by contrast, do have clinical features and some of them show squamous epithelial dysplasia on histological examination. Lung carcinoma arises from bronchial epithelium and alveolar epithelium. There is evidence that intraepithelial neoplasia (pre-invasive, preneoplastic lesions) of bronchial epithelium (basal cell, columnar cell or metaplastic squamous epithelium) and alveolar epithelium precedes the development of lung carcinoma. Intraepithelial neoplasia shows varying degrees of bronchial and alveolar epithelial dysplasia accompanied by molecular change. Intraepithelial neoplasia is graded into low- and high-grade depending on the degree of nuclear atypia and irregularity of cellular arrangement.

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Author information

Authors and Affiliations

  1. Department of Pathology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, China

    Guofeng Wang MD

  2. Department of Pathology, School of Medicine, Zhejiang University, China

    Maode Lai M.D.

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  1. Guofeng Wang MD
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  2. Maode Lai M.D.
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Editors and Affiliations

  1. School of Medicine, Zhejiang University, 310058, Hangzhou, China

    Maode Lai

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© 2009 Higher Education Press, Beijing and Springer-Verlag GmbH Berlin Heidelberg

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Wang, G., Lai, M. (2009). Intraepithelial Neoplasia of the Respiratory Tract. In: Lai, M. (eds) Intraepithelial Neoplasia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85453-1_1

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  • DOI: https://doi.org/10.1007/978-3-540-85453-1_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-85452-4

  • Online ISBN: 978-3-540-85453-1

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