Zusammenfassung
In diesem Kapitel werden alle nicht von Lymphozyten abgeleiteten Neoplasien, die primär im Lymphknoten auftreten, behandelt. Es sind einerseits seltene spezifische Neoplasien, wie das palisadenförmige Myofibroblastom, Neoplasien der nicht-lymphozytären Zellen des Lymphknotens, wie verschiedene Formen der malignen Histiozytosen, der Mastozytosen, der Tumoren der dendritischen Zellarten und unterschiedliche Neoplasien der Blut- und Lymphgefäße des Lymphknotens. Diese Tumoren sind zwar selten, erfordern aber wegen ihrer besonderen Ausprägung im Lymphknoten als wichtige Differenzialdiagnosen eine spezielle Beachtung.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsLiteratur
Alten J, Klapper W, Leuschner I, Eckert C, Beier R, Vallo E, Krause M, Claviez A, Vieth S, Bleckmann K, Moricke A, Schrappe M, Cario G (2015) Secondary histiocytic sarcoma may cause apparent persistence or recurrence of minimal residual disease in childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 62:1656–1660
Badalian-Very G, Vergilio JA, Degar BA, MacConaill LE, Brandner B, Calicchio ML, Kuo FC, Ligon AH, Stevenson KE, Kehoe SM, Garraway LA, Hahn WC, Meyerson M, Fleming MD, Rollins BJ (2010) Recurrent BRAF mutations in Langerhans cell histiocytosis. Blood 116:1919–1923
Badalian-Very G, Vergilio JA, Fleming M, Rollins BJ (2013) Pathogenesis of Langerhans cell histiocytosis. Annu Rev Pathol 8:1–20
Chan AC, Chan KW, Chan JK, Au WY, Ho WK, Ng WM (2001) Development of follicular dendritic cell sarcoma in hyaline-vascular Castleman’s disease of the nasopharynx: tracing its evolution by sequential biopsies. Histopathology 38:510–518
Chan JK, Fletcher CD, Nayler SJ, Cooper K (1997) Follicular dendritic cell sarcoma. Clinicopathologic analysis of 17 cases suggesting a malignant potential higher than currently recognized. Cancer 79:294–313
Chan JK, Frizzera G, Fletcher CD, Rosai J (1992) Primary vascular tumors of lymph nodes other than Kaposi’s sarcoma. Analysis of 39 cases and delineation of two new entities. Am J Surg Pathol 16:335–350
Chen W, Jaffe R, Zhang L, Hill C, Block AM, Sait S, Song B, Liu Y, Cai D (2013) Langerhans cell sarcoma arising from chronic lymphocytic lymphoma/small lymphocytic leukemia: lineage analysis and BRAF V600E mutation study. N Am J Med Sci 5:386–391
Chilosi M, Facchetti F, Calio A, Zamo A, Brunelli M, Martignoni G, Rossi A, Montagna L, Piccoli P, Dubini A, Tironi A, Tomassetti S, Poletti V, Doglioni C (2014) Oncogene-induced senescence distinguishes indolent from aggressive forms of pulmonary and non-pulmonary Langerhans cell histiocytosis. Leuk Lymphoma 55:2620–2626
Cimpean AM, Raica M (2013) Intranodal hemorrhagic spindle cell tumor with amianthoid fibers - report of a case with emphasis to mast cell reaction and d2-40 expression. In Vivo (Brooklyn) 27:395–399
Dalia S, Jaglal M, Chervenick P, Cualing H, Sokol L (2014) Clinicopathologic characteristics and outcomes of histiocytic and dendritic cell neoplasms: the moffitt cancer center experience over the last twenty five years. Cancers (Basel) 6:2275–2295
de Saint-Maur PP, Audouin J, Cazier A, Le Tourneau A, Molina T, Diebold J (2011) Nodal intralymphatic papillary endothelial tumour with Dabska-like features: report of a case in two mesenteric lymph nodes. Histopathology 59:1027–1029
Ducassou S, Seyrig F, Thomas C, Lambilliotte A, Marec-Berard P, Berger C, Plat G, Brugiere L, Ouache M, Barkaoui M, Armari-Alla C, Lutz P, Leverger G, Rialland X, Mansuy L, Pacquement H, Jeziorski E, Gandemer V, Chalard F, Chateil JF, Tazi A, Emile JF, Donadieu J, Investigators of the French LCHSG (2013) Thymus and mediastinal node involvement in childhood Langerhans cell histiocytosis: long-term follow-up from the French national cohort. Pediatr Blood Cancer 60:1759–1765
Edelweiss M, Medeiros LJ, Suster S, Moran CA (2007) Lymph node involvement by Langerhans cell histiocytosis: a clinicopathologic and immunohistochemical study of 20 cases. Hum Pathol 38:1463–1469
Facchetti F, Incardona P, Lonardi S, Fisogni S, Legrenzi L, Chioda C, Ponzoni M, Chiodera PL (2009) Nodal inflammatory pseudotumor caused by luetic infection. Am J Surg Pathol 33:447–453
Falleti J, Siano M, De Cecio R, Somma A, Pettinato G, Insabato L (2009) Nodal and extranodal soft tissue polymorphous hemangioendothelioma: a case report and review of the literature. Tumori 95:94–97
Feldman AL (2013) Clonal relationships between malignant lymphomas and histiocytic/dendritic cell tumors. Surg Pathol Clin 6:619–629
Feldman AL, Arber DA, Pittaluga S, Martinez A, Burke JS, Raffeld M, Camos M, Warnke R, Jaffe ES (2008) Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone. Blood 111:5433–5439
Flucke U, Vogels RJ, de Saint Aubain Somerhausen N, Creytens DH, Riedl RG, van Gorp JM, Milne AN, Huysentruyt CJ, Verdijk MA, van Asseldonk MM, Suurmeijer AJ, Bras J, Palmedo G, Groenen PJ, Mentzel T (2014) Epithelioid Hemangioendothelioma: clinicopathologic, immunhistochemical, and molecular genetic analysis of 39 cases. Diagn Pathol 9:131
Fonseca R, Yamakawa M, Nakamura S, van Heerde P, Miettinen M, Shek TW, Myhre Jensen O, Rousselet MC, Tefferi A (1998) Follicular dendritic cell sarcoma and interdigitating reticulum cell sarcoma: a review. Am J Hematol 59:161–167
Gandhi A, Malhotra KP, Sharma S (2015) Inflammatory myofibroblastic tumor of inguinal lymph nodes, simulating lymphoma. J Cancer Res Ther 11:645
Go H, Jeon YK, Huh J, Choi SJ, Choi YD, Cha HJ, Kim HJ, Park G, Min S, Kim JE (2014) Frequent detection of BRAF(V600E) mutations in histiocytic and dendritic cell neoplasms. Histopathology 65:261–272
Harmon CM, Brown N (2015) Langerhans cell histiocytosis: a clinicopathologic review and molecular pathogenetic update. Arch Pathol Lab Med 139:1211–1214
Haroche J, Cohen-Aubart F, Emile JF, Arnaud L, Maksud P, Charlotte F, Cluzel P, Drier A, Hervier B, Benameur N, Besnard S, Donadieu J, Amoura Z (2013) Dramatic efficacy of vemurafenib in both multisystemic and refractory Erdheim-Chester disease and Langerhans cell histiocytosis harboring the BRAF V600E mutation. Blood 121:1495–1500
Hervier B, Haroche J, Arnaud L, Charlotte F, Donadieu J, Neel A, Lifermann F, Villabona C, Graffin B, Hermine O, Rigolet A, Roubille C, Hachulla E, Carmoi T, Bezier M, Meignin V, Conrad M, Marie L, Kostrzewa E, Michot JM, Barete S, Taly V, Cury K, Emile JF, Amoura Z, French Histiocytoses Study G (2014) Association of both Langerhans cell histiocytosis and Erdheim-Chester disease linked to the BRAFV600E mutation. Blood 124:1119–1126
Hisaoka M, Hashiomoto H, Daimaru Y (1998) Intranodal palisaded myofibroblastoma with so-called amianthoid fibers: a report of two cases with a review of the literature. Pathol Int 48:307–312
Horny HP, Ruck P, Krober S, Kaiserling E (1997) Systemic mast cell disease (mastocytosis). General aspects and histopathological diagnosis. Histol Histopathol 12:1081–1089
Hure MC, Elco CP, Ward D, Hutchinson L, Meng X, Dorfman DM, Yu H (2012) Histiocytic sarcoma arising from clonally related mantle cell lymphoma. J Clin Oncol 30:e49–e53
Jones D (2010) Histiocytic and dendritic cell neoplasms. Surg Pathol Clin 3:1165–1183
Kandemir NO, Barut F, Ekinci T, Karagulle C, Ozdamar SO (2010) Intranodal palisaded myofibroblastoma (intranodal hemorrhagic spindle cell tumor with amianthoid fibers): a case report and literature review. Diagn Pathol 5:12
Kansal R, Quintanilla-Martinez L, Datta V, Lopategui J, Garshfield G, Nathwani BN (2013) Identification of the V600D mutation in Exon 15 of the BRAF oncogene in congenital, benign langerhans cell histiocytosis. Genes Chromosomes Cancer 52:99–106
Kleist B, Poetsch M, Schmoll J (2003) Intranodal palisaded myofibroblastoma with overexpression of cyclin D1. Arch Pathol Lab Med 127:1040–1043
Krokowski M, Merz H, Thorns C, Bernd HW, Schade U, Le Tourneau A, Diebold J, Feller AC (2008) Sarcoma of follicular dendritic cells with features of sinus lining cells – a new subtype of reticulum cell sarcoma? Virchows Arch 452:565–570
Kuo TT, Shih LY, Chan HL (1988) Kimura’s disease. Involvement of regional lymph nodes and distinction from angiolymphoid hyperplasia with eosinophilia. Am J Surg Pathol 12:843–854
Montes-Moreno S, Garcia OA, Santiago-Ruiz G, Ferreira JA, Garcia JF, Pinilla MA (2010) Primary luetic lymphadenopathy simulating sarcoma-like inflammatory pseudotumour of the lymph node. Histopathology 56:656–658
Nakamura S, Hara K, Suchi T, Ito M, Ikeda H, Nagahama M, Nakayama A, Nakagawa A, Kaneshima H, Asai J (1988) Interdigitating cell sarcoma. A morphologic, immunohistologic, and enzyme-histochemical study. Cancer 61:562–568
Nguyen T, Eltorky MA (2007) Intranodal palisaded myofibroblastoma. Arch Pathol Lab Med 131:306–310
O’Malley DP, Agrawal R, Grimm KE, Hummel J, Glazyrin A, Dim DC, Madhusudhana S, Weiss LM (2015) Evidence of BRAF V600E in indeterminate cell tumor and interdigitating dendritic cell sarcoma. Ann Diagn Pathol 19:113–116
O’Malley DP, Duong A, Barry TS, Chen S, Hibbard MK, Ferry JA, Hasserjian RP, Thompson MA, Richardson MS, Jaffe R, Sidhu JS, Banks PM (2010) Co-occurrence of Langerhans cell histiocytosis and Rosai-Dorfman disease: possible relationship of two histiocytic disorders in rare cases. Mod Pathol 23:1616–1623
Ohtake H, Yamakawa M (2013) Interdigitating dendritic cell sarcoma and follicular dendritic cell sarcoma: histopathological findings for differential diagnosis. J Clin Exp Hematop 53:179–184
Perkins SM, Shinohara ET (2013) Interdigitating and follicular dendritic cell sarcomas: a SEER analysis. Am J Clin Oncol 36:395–398
Pileri SA, Grogan TM, Harris NL, Banks P, Campo E, Chan JK, Favera RD, Delsol G, De Wolf-Peeters C, Falini B, Gascoyne RD, Gaulard P, Gatter KC, Isaacson PG, Jaffe ES, Kluin P, Knowles DM, Mason DY, Mori S, Muller-Hermelink HK, Piris MA, Ralfkiaer E, Stein H, Su IJ, Warnke RA, Weiss LM (2002) Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the International Lymphoma Study Group based on 61 cases. Histopathology 41:1–29
Requena L, Kutzner H (2013) Hemangioendothelioma. Semin Diagn Pathol 30:29–44
Satpathy AT, Tan BT (2015) Cellular morphology of BRAF V600E-positive Langerhans cell histiocytosis. Blood 126:1857
Saygin C, Uzunaslan D, Ozguroglu M, Senocak M, Tuzuner N (2013) Dendritic cell sarcoma: a pooled analysis including 462 cases with presentation of our case series. Crit Rev Oncol Hematol 88:253–271
Sotlar K, Saeger W, Stellmacher F, Stahmer J, Jackle S, Valent P, Horny HP (2006) „Occult“ mastocytosis with activating c-kit point mutation evolving into systemic mastocytosis associated with plasma cell myeloma and secondary amyloidosis. J Clin Pathol 59:875–878
Tanda F, Massarelli G, Cossu A, Bosincu L, Cossu S, Ibba M (1993) Primary spindle cell tumor of lymph node with „amianthoid“ fibers: a histological, immunohistochemical and ultrastructural study. Ultrastruct Pathol 17:195–205
Tantravahi SK, Salama ME, Deininger MN (2014) Aggressive systemic mastocytosis mimicking lymphoma: description of an unusual presentation and review of the literature on current management strategies. Leuk Lymphoma 55:2963–2966
Van der Valk P, Ruiter DJ, Den Ottolander GJ, Te Velde J, Spaander PJ, Meijer CJ (1982) Dendritic reticulum cell sarcoma? Four cases of a lymphoma probably derived from dendritic reticulum cells of the follicular compartment. Histopathology 6:269–287
Vermi W, Facchetti F, Rosati S, Vergoni F, Rossi E, Festa S, Remotti D, Grigolato P, Massarelli G, Frizzera G (2004) Nodal and extranodal tumor-forming accumulation of plasmacytoid monocytes/interferon-producing cells associated with myeloid disorders. Am J Surg Pathol 28:585–595
Vos JA, Abbondanzo SL, Barekman CL, Andriko JW, Miettinen M, Aguilera NS (2005) Histiocytic sarcoma: a study of five cases including the histiocyte marker CD163. Mod Pathol 18:693–704
Wang E, Hutchinson CB, Huang Q, Sebastian S, Rehder C, Kanaly A, Moore J, Datto M (2010) Histiocytic sarcoma arising in indolent small B-cell lymphoma: report of two cases with molecular/genetic evidence suggestive of a ’transdifferentiation’ during the clonal evolution. Leuk Lymphoma 51:802–812
West DS, Dogan A, Quint PS, Tricker-Klar ML, Porcher JC, Ketterling RP, Law ME, McPhail ED, Viswanatha DS, Kurtin PJ, Dao LN, Ritzer RD, Nowakowski GS, Feldman AL (2013) Clonally related follicular lymphomas and Langerhans cell neoplasms: expanding the spectrum of transdifferentiation. Am J Surg Pathol 37:978–986
Wu A, Pullarkat S (2016) Follicular dendritic cell sarcoma. Arch Pathol Lab Med 140:186–190
Xu Z, Jamison B, Bence-Bruckler I (2014) Smouldering systemic mastocytosis with lymph node involvement mimicking malignant lymphoma. Ann Hematol 93:1603–1604
Yu H, Gibson JA, Pinkus GS, Hornick JL (2007) Podoplanin (D2-40) is a novel marker for follicular dendritic cell tumors. Am J Clin Pathol 128:776–782
Zhang D, McGuirk J, Ganguly S, Persons DL (2009) Histiocytic/dendritic cell sarcoma arising from follicular lymphoma involving the bone: a case report and review of literature. Int J Hematol 89:529–532
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature
About this chapter
Cite this chapter
Müller-Hermelink, H.K., Rüdiger, T. (2019). Nichtlymphatische Tumoren des Lymphknotens. In: Müller-Hermelink, H., Kreipe, H. (eds) Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85184-4_28
Download citation
DOI: https://doi.org/10.1007/978-3-540-85184-4_28
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-85183-7
Online ISBN: 978-3-540-85184-4
eBook Packages: Medicine (German Language)