Zusammenfassung
Dieses Kapitel stellt statistische Verfahren zur Auswertung einer klinischen Studie mit einem kategoriellen Merkmal als primärem Zielkriterium vor. Es behandelt im Wesentlichen Methoden für qualitativ messbare Zielkriterien mit nur zwei Ausprägungen, auch binäre oder dichotome Zielkriterien genannt. Ein binäres Zielkriterium ist beispielsweise die Kategorisierung des Behandlungsergebnisses in Erfolg und Misserfolg. Die meisten der vorgestellten Methoden lassen sich auf Zielkriterien mit mehr als zwei Kategorien verallgemeinern. Zur Darstellung der Vorgehensweise bei der statistischen Auswertung einer klinischen Studie mit qualitativem Zielkriterium ziehen wir eine Therapiestudie zur Wirksamkeit eines neuen Thrombolytikums zur Behandlung des akuten Herzinfarktes heran.
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Schumacher, M., Schulgen/Kristiansen, G., Olschewski, M. (2008). Statistische Analyse eines qualitativen Zielkriteriums - Auswertung einer klinischen Studie zur Behandlung des akuten Herzinfarkts. In: Methodik klinischer Studien. Statistik und ihre Anwendungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85136-3_4
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