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Applications of Scanning Near-Field Optical Microscopy in Life Science

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Applied Scanning Probe Methods XII

Part of the book series: NanoScience and Technology ((NANO))

Abstract

Scanning Near-Field Optical Microscopy (SNOM) is capable of attaining sub-diffraction resolution by exploiting nanoscopic light sources to illuminate the samples, such as nanoapertures or sharp metallic tips. In this chapter, after describing the basic principles of SNOM, we review the state-of-the-art in the experimental implementations and applications of fluorescence, infrared and Raman SNOM for the detection and imaging of DNA oligonucleotides, viruses and cellular membrane proteins.

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Authors and Affiliations

  1. CNR-Istituto per i Processi Chimico-Fisici, Salita Sperone c.da Papardo, I-98158 Messina, Italy

    Pietro Giuseppe Gucciardi

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  1. Pietro Giuseppe Gucciardi
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Editors and Affiliations

  1. Nanoprobe Laboratory for Bio- & Nanotechnology & Biomimetics (NLB2), Ohio State University, 201 W. 19th Ave, Columbus, Ohio 43210-1142, USA

    Bharat Bhushan

  2. Universität Münster FB 16 Physikalisches Institut, Wilhelm-Klemm-Str. 10, 48149 Münster, Germany

    Harald Fuchs

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Gucciardi, P.G. (2009). Applications of Scanning Near-Field Optical Microscopy in Life Science. In: Bhushan, B., Fuchs, H. (eds) Applied Scanning Probe Methods XII. NanoScience and Technology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85039-7_3

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