Skip to main content

Pitfalls Related to Inflammatory Disorders

  • Chapter
  • 1384 Accesses

Surgery for spinal inflammatory disorders represents a measure to manage progressive conditions nonrespond-ing to conservative treatment.Surgery in these often fragile patients has to deal with their associated systemic illnesses, including low bone density, poor renal and metabolic function, secondary diabetes from corti-costeroid treatment, secondary immunodeficiency from the use of immunosuppressant drugs, and poor respiratory function.The treatment of these conditions requires highly specialized centers providing integrated care, with dedicated anesthesiologists, rheumatologists, and surgeons.Surgery is necessary in a minority of patients, and most surgeons will never perform this surgery, which is difficult, risky, and often life-threatening.

Analysis of complications of surgery in inflamma-tory disorders of the cervical spine will deal with patients affected by rheumatoid arthritis (RA) and anky-losing spondylitis (AS), which are the most common inflammatory diseases affecting this spinal segment.RA normally affects the hypermobile segments.Therefore, the cervical spine is the most common involved spinal segment in patients with RA, because of its hypermobility.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Bland JH, Eddy WM (1968) Hemiplegia and rheumatoid hemiarthritis. Arthritis Rheum 11:72–79

    Article  PubMed  CAS  Google Scholar 

  2. Boden SD, Dodge LD, Bohlman HH, Rechtine GR (1993) Rheumatoid arthritis of the cervical spine. A long term analysis with predictors of paralysis and recovery. J Bone Joint Surg 75A:1282–1297

    Google Scholar 

  3. Mark JS, Sharp J (1981) Rheumatoid cervical myelopathy. Q J Med 199:307–319

    Google Scholar 

  4. Plotz GM, Schutz U, Grob D (1998) Occipitocervical fusion in chronic polyarthritis. Z Rheumatol 57:147–158

    Article  PubMed  CAS  Google Scholar 

  5. Henderson FC, Geddes JF, Crockard HA (1993) Neuropa-thology of the brainstem and spinal cord in end stage rheumatoid arthritis: implications for treatment. Ann Rheum Dis 52:629–637

    Article  PubMed  CAS  Google Scholar 

  6. Corbett M, Dalton S, Young A, Silman A, Shipley M (1993) Factors predicting death, survival and functional outcome in a prospective study of early rheumatoid disease over fifteen years. Br J Rheumatol 32:717–723

    Article  PubMed  CAS  Google Scholar 

  7. Neva MH, Myllykangas-Luosujarvi R, Kautiainen H, Kauppi M (2001) Mortality associated with cervical spine disorders: a population-based study of 1666 patients with rheumatoid arthritis who died in Finland in 1989. Rheumatology 40:123–127

    Article  PubMed  CAS  Google Scholar 

  8. O'Brien MF, Casey AT, Crockard A, Pringle J, Stevens JM (2002) Histology of the craniocervical junction in chronic rheumatoid arthritis: a clinicopathologic analysis of 33 operative cases. Spine 27(20):2245–2254

    Article  PubMed  Google Scholar 

  9. Casey AT, Crockard HA, Bland JM, Stevens J, Moskovich R, Ransford A (1996) Predictors of outcome in the quadripa-retic nonambulatory myelopathic patient with rheumatoid arthritis: a prospective study of 55 surgically treated Ranawat class IIIb patients. J Neurosurg 85:574–581

    Article  PubMed  CAS  Google Scholar 

  10. Casey AT, Crockard HA (1995) In the rheumatoid patient: surgery to the cervical spine. Br J Rheumatol 34:1079–1086

    Article  PubMed  CAS  Google Scholar 

  11. Brislin BT, Hilibrand AS, Taylor BA (2002) Complications of anterior and posterior cervical instrumentation. In: Vaccaro AR, Betz RR, Zeidman SM (eds) Principles and practice of spine surgery. C.V. Mosby, St. Louis

    Google Scholar 

  12. Casey AT, Crockard HA, Bland JM et al (1996) Surgery on the rheumatoid cervical spine for the non-ambulant myelo-pathic patient — too much too late? Lancet 347:1004–1007

    Article  PubMed  CAS  Google Scholar 

  13. Christensson D, Saveland H, Rydholm U (2000) Cervical spine surgery in rheumatoid arthritis. A Swedish nationwide registration of 83 patients. Scand J Rheumatol 29:314–319

    Article  PubMed  CAS  Google Scholar 

  14. Hamilton JD, Gordon MM, McInnes IB et al (2000) Improved medical and surgical management of cervical spine disease in patients with rheumatoid arthritis over 10 years. Ann Rheum Dis 59:434–438

    Article  PubMed  CAS  Google Scholar 

  15. Redlund-Johnell I (1985) Cervical dislocations in rheumatoid arthritis. Lakartidningen 82:4510–4512

    PubMed  CAS  Google Scholar 

  16. Casey ATH, Crockard HA, Pringle J, O'Brien MF, Stevens JM (2002) Rheumatoid arthritis of the cervical spine: current techniques for management. Orthop Clin North Am 33:291–309

    Article  PubMed  Google Scholar 

  17. Santavirta S, Konttinen YT, Sanelin J et al (1990) Operations for the unstable cervical spine in rheumatoid arthritis: sixteen cases of subaxial subluxation. Acta Orthop Scand 61:106–110

    Article  PubMed  CAS  Google Scholar 

  18. Eulderink F, Meijers KAE (1976) Pathology of the cervical spine in rheumatoid arthritis: a controlled study of 44 spines. J Pathol 120:91–108

    Article  PubMed  CAS  Google Scholar 

  19. Larsson EM, Holtas S, Zygmut S (1989) Pre- and postoperative MR imaging of the craniocervical junction in rheumatoid arthritis. Am J Rheumatol 152:561–566

    CAS  Google Scholar 

  20. Halla JT, Jr Hardin JG (1990) The spectrum of atlanto-axial facet joint involvement in rheumatoid arthritis. Arthritis Rheum 33:325–329

    Article  PubMed  CAS  Google Scholar 

  21. Krieg JC, Clark CR, Goetz DD (1993) Cervical spine arthro-desis in rheumatoid arthritis: a long-term follow-up. Yale J Biol Med 66:257–262

    PubMed  CAS  Google Scholar 

  22. Olerud C, Larsson BE, Rodriguez M (1997) Subaxial cervical spine subluxation in rheumatoid arthritis: a retrospective analysis of 16 operated patients after 1–5 years. Acta Orthop Scand 68:109–115

    Article  PubMed  CAS  Google Scholar 

  23. Santavirta S, Konttinen YT, Laasonen E et al (1991) Ten-year results of operations for rheumatoid cervical spine disorders. J Bone Joint Surg 73:116–120

    CAS  Google Scholar 

  24. Agarwal AK, Peppelman WC, Kraus DR et al (1992) Recurrence of cervical spine instability in rheumatoid arthritis following previous fusion: can disease progression be prevented by early surgery? J Rheumatol 19:1364–1370

    PubMed  CAS  Google Scholar 

  25. Kraus DR, Peppelman WC, Agarwaal AK et al (1991) Incidence of subaxial subluxation in patients with generalized rheumatoid arthritis who have had previous occipital cervical fusions. Spine 16(Suppl10):486–489

    Article  Google Scholar 

  26. Zygmunt SC, Christensson D, Saveland H et al (1995) Occipito-cervical fixation in rheumatoid arthritis — an analysis of surgical risk factors in 163 patients. Acta Neurochir (Wien) 135:25–31

    Article  CAS  Google Scholar 

  27. Matsunaga S, Onishi T, Sakou T (2001) Significance of occipitoaxial angle in subaxial lesion after occipitocervical fusion. Spine 26:161–165

    Article  PubMed  CAS  Google Scholar 

  28. Crockard HA, Calder I, Ransford AO (1990) One-stage tran-soral decompression and posterior fixation in rheumatoid atlanto-axial subluxation. J Bone Joint Surg Br 72B:682–685

    Google Scholar 

  29. Crockard HA, Essigman WK, Stevens JM et al (1985) Surgical treatment of cervical cord compression in rheumatoid arthritis. Ann Rheum Dis 44:809–816

    Article  PubMed  CAS  Google Scholar 

  30. Crockard HA, Pozo JL, Ransford AO et al (1986) Transoral decompression and posterior fusion for rheumatoid atlanto-axial subluxation. J Bone Joint Surg Br 68B:350–356

    Google Scholar 

  31. Crockard HA (1995) Spine update: surgical management of cervical rheumatoid problems. Spine 20(23):2584–2590

    Article  PubMed  CAS  Google Scholar 

  32. Crockard HA (1985) The transoral approach to the base of the brain and upper cervical cord. Ann R Coll Surg Engl 67:321–325

    PubMed  CAS  Google Scholar 

  33. Crockard HA (1995) Transoral surgery: some lessons learned. Br J Neurosurg 9:283–293

    Article  PubMed  CAS  Google Scholar 

  34. Grob D, Wursch R, Grauer W et al (1997) Atlantoaxial fusion and retrodental pannus in rheumatoid arthritis. Spine 22(14):1580–1583

    Article  PubMed  CAS  Google Scholar 

  35. O'Brien MF (1998) The craniocervical junction: anterior problems and surgical solutions. In: Devlin VJ (ed) Anterior spinal column surgery: spine: state of the art review. Hanley & Belfus, Philadelphia, pp 529–570

    Google Scholar 

  36. Dickman CA, Locantro J, Fessler RG (1992) The influence of transoral odontoid resection on stability of the craniover-tebral junction. J Neurosurg 77(4):525–530

    Article  PubMed  CAS  Google Scholar 

  37. Kandziora F, Mittlmeier T, Kerschbaumer F (1999) Stage-related surgery for cervical spine instability in rheumatoid arthritis. Eur Spine J 8:371–381

    Article  PubMed  CAS  Google Scholar 

  38. Casey ATH, Crockard HA, Stevens J (1997) Vertical translo-cation. Part II. Outcomes after surgical treatment of rheumatoid cervical myelopathy. J Neurosurg 87:863–869

    Article  PubMed  CAS  Google Scholar 

  39. Denaro V (1992) Artrite reumatoide a localizzazione cervicale bassa (C3–C7). Giornale Italiano di Ortopedia e Traumatologia. Estratti dal LXXVII congresso della SIOT. 131–136

    Google Scholar 

  40. Urist MR (1958) Osteotomy of the cervical spine. J Bone Joint Surg Am 40:833–843

    PubMed  Google Scholar 

  41. Vale FL, Oliver M, Cahill DW (1999) Rigid occipitocervical fusion. J Neurosurg 91(Suppl 2):144–150

    PubMed  CAS  Google Scholar 

  42. Vanden Berghe A, Ackerman C, Veys E et al (1991) Occipitocervical fusion in rheumatoid arthritis. Acta Orthop Belg 57(Suppl 1):94–98

    PubMed  Google Scholar 

  43. Denaro E (1991) Stenosis of the cervical spine causes, diagnosis and treatment. Springer, Berlin

    Book  Google Scholar 

  44. Roy-Camille R, Mazel CH, Saillant G (1987) Treatment of cervical spine injuries by a posterior osteosynthesis with plate and screws. In: Kehr P, Weidner A (eds) cervical spine I. Springer, Berlin

    Google Scholar 

  45. An HS (1995) Internal fixation of the cervical spine: current indications and techniques. J Am Acad Orthop Surg 3:194–206

    PubMed  Google Scholar 

  46. Wertheim SB (1987) Occipitocervical fusion: indications, techniques, and long term results in thirteen patients. J Bone Joint Surg Am 69:833–836

    PubMed  CAS  Google Scholar 

  47. Mc Cullen GM, Garfin SR (2000) Spine update: cervical spine internal fixation using screw and screw-plate constructs. Spine 25:643–652

    Article  PubMed  CAS  Google Scholar 

  48. Matsunaga S, Ijiri K, Koga H (2000) Results of a longer than 10-year follow-up of patients with rheumatoid arthritis treated by occipitocervical fusion. Spine 25(14):1749–1753

    Article  PubMed  CAS  Google Scholar 

  49. Deutsch H, Haid RW, Rodts GE, Mummaneni PV (2005) Occipitocervical fixation: long-term results. Spine 30(5):530–535

    Article  PubMed  Google Scholar 

  50. Heidecke V, Rainov NG, Burkert W (1998) Occipito-cervical fusion with the cervical Cotrel-Dubousset rod system. Acta Neurochir (Wien) 140(9):969–976

    Article  CAS  Google Scholar 

  51. An HS, Cooper M (1998) Cervical spine instrumentation. In: An HS (ed) Principles and techniques of spine surgery. Williams & Wilkins, Philadelphia, pp 65–73

    Google Scholar 

  52. Ebraheim NA, Rupp RE, Savolaine ER, Brown JA (1995) Posterior plating of the cervical spine. J Spinal Disord 8:111–115

    Article  PubMed  CAS  Google Scholar 

  53. Grob D, Dvorak J, Panjabi MM et al (1994) The role of plate and screw fixation in occipitocervical fusion in rheumatoid arthritis. Spine 19:2545–2551

    Article  PubMed  CAS  Google Scholar 

  54. Joseph V, Al Jahwari AS, Rampersaud YR (2008) Mediastinal migration of distal occipito-thoracic instrumentation. Eur Spine J 17(Suppl 2):S257–S262

    Article  PubMed  Google Scholar 

  55. Edwend M, Ducker TB (1993) Rheumatoid C1–2 spinal instability. J Spinal Disord 6:535–536

    Article  Google Scholar 

  56. Eyres KS, Gray DH, Robertson P (1998) Posterior surgical treatment for the rheumatoid cervical spine. Br J Rheumatol 37:756–759

    Article  PubMed  CAS  Google Scholar 

  57. Fehring TK, Brooks AL (1987) Upper cervical instability in rheumatoid arthritis. Clin Orthop 221:137–148

    PubMed  Google Scholar 

  58. Grob D, Dvorak J, Panjabi M et al (1991) Posterior occipito-cervical fusion: a preliminary report of a new technique. Spine 16(Suppl 3):S17–S24

    Article  PubMed  CAS  Google Scholar 

  59. Millbrink J, Nyman R (1990) Posterior stabilization of the cervical spine in rheumatoid arthritis: clinical results and magnetic resonance imaging correlation. J Spinal Disord 3:308–315

    Article  Google Scholar 

  60. Shen FH, Samartzis D, Jenis LG, An HS (2004) Rheumatoid arthritis: evaluation and surgical management of the cervical spine. Spine J 4:689–700

    Article  PubMed  Google Scholar 

  61. Szpalski M, Gunzburg R (2002) What are the advances for surgical therapy of inflammatory diseases of the spine? Best Pract Res Clin Rheumatol 16(1):141–154

    Article  PubMed  Google Scholar 

  62. Christensson D, Saveland H, Zygmunt S et al (1999) Cervical laminectomy without fusion in patients with rheumatoid arthritis. J Neurosurg 90(Suppl 4):186–190

    PubMed  CAS  Google Scholar 

  63. Stambough JL, Balderston RA, Grey S (1990) Technique for occipito-cervical fusion in osteopenic patients. J Spinal Disord 3:404–407

    PubMed  CAS  Google Scholar 

  64. Ito H, Neo M, Fujibayashi S, Miyata M, Yoshitomi H, Nakamura T (2008) Atlantoaxial transarticular screw fixa-tion with posterior wiring using polyethylene cable. Spine 33(15):1655–1661

    Article  PubMed  Google Scholar 

  65. Harms J, Melcher RP (2001) Posterior C1-C2 fusion with polyaxial screw and rod fixation. Spine 26:2467–2471

    Article  PubMed  CAS  Google Scholar 

  66. Calin A, Elswood J (1988) The relationship between pelvic, spinal and hip involvement in ankylosing spondylitis–one disease process or several? Br J Rheumatol 27(5):393–395

    Article  PubMed  CAS  Google Scholar 

  67. Calin A (1985) Ankylosing spondylitis. In: Kelley WN (ed) Textbook of rheumatology. WB Saunders, Philadelphia, pp 993–1006

    Google Scholar 

  68. Smith-Petersen MN, Larson CB, Aufranc OE (1945) Osteotomy of the spine for correction of flexion deformity in rheumatoid arthritis. J Bone Joint Surg Am 27:1–11

    Google Scholar 

  69. Simmons ED, DiStefano RJ, Zheng Y, Simmons EH (2006) Thirty-six years experience of cervical extension osteotomy in ankylosing spondylitis. Spine 31(26):006–3012

    Article  Google Scholar 

  70. McMaster MJ (1997) Osteotomy of the cervical spine in anky-losing spondylitis. J Bone Joint Surg Br 79(2):197–203

    Article  PubMed  CAS  Google Scholar 

  71. Hoh DJ, Khoueir P, Wang MY (2008) Management of cervical deformity in ankylosing spondylitis. Neurosurg Focus 24(1):E9

    Article  PubMed  Google Scholar 

  72. Shimizu K, Matsushita M, Fujibayashi S, Toguchida J, Ido K, Nakamura T (1996) Correction of kyphotic deformity of the cervical spine in ankylosing spondylitis using general anesthesia and internal fixation. J Spinal Disord 9:540–543

    Article  PubMed  CAS  Google Scholar 

  73. Mehdian SM, Freeman BJ, Licina P (1999) Cervical osteotomy for ankylosing spondylitis: an innovative variation on an existing technique. Eur Spine J 8:505–509

    Article  PubMed  CAS  Google Scholar 

  74. McAfee PC, Cassidy JR, Davis RF et al (1991) Fusion of the occiput to the upper cervical spine: a review of 37 cases. Spine 16(Suppl 10):S490–S494

    Article  PubMed  CAS  Google Scholar 

  75. Sansur CA, Fu KG, jr Oskouian RJ, Jagannathan J, Kuntz C IV, Shaffrey CI (2008) Surgical management of global sagittal deformity in ankylosing spondylitis. Neurosurg Focus 24(1):E8

    Article  PubMed  Google Scholar 

  76. Graham AW, Swank ML, Kinard RE et al (1996) Posterior cervical arthrodesis and stabilization with a lateral mass plate. Spine 21:323–329

    Article  PubMed  CAS  Google Scholar 

  77. Hunter T, Dubo H (1978) Spinal fractures complicating ankylosing spondylitis. Ann Intern Med 88(4):546–549

    Article  PubMed  CAS  Google Scholar 

  78. Olerud C, Frost A, Bring J (1996) Spinal fractures in patients with ankylosing spondylitis. Eur Spine J 5(1):51–55

    Article  PubMed  CAS  Google Scholar 

  79. Westerveld LA, Verlaan JJ, Oner FC (2009). Spinal fractures in patients with ankylosing spinal disorders: a systematic review of the literature on treatment, neurological status and complications. Eur Spine J 18(2):145–156

    Article  PubMed  CAS  Google Scholar 

  80. Denaro V, Gulino G, Papapietro N, Denaro L (1998) Treatment of metastasis of the cervical spine. Chir Organi Mov 83:127–137

    PubMed  CAS  Google Scholar 

  81. Denaro V (1988) Treatment of metastases and systemic tumors of the cervical spine. Neuro Orthopedics 6:101–110

    Google Scholar 

  82. Amamilo SC (1989) Fractures of the cervical spine in patients with ankylosing spondylitis. Orthop Rev 18(3):339–344

    PubMed  CAS  Google Scholar 

  83. Bland JH (1974) Rheumatoid arthritis of the cervical spine. J Rheumatol 1:319–341

    Google Scholar 

  84. Casey ATH, Crockard HA, Geddes JF, Stevens J (1997) Vertical translocation: the enigma of the disappearing atlan-todens interval in patients with myelopathy and rheumatoid arthritis. Part I. Clinical, radiological, and neuropathological features. J Neurosurg 87:856–862

    Article  PubMed  CAS  Google Scholar 

  85. Crockard HA, Johnston F (1993) Development of transoral approaches to lesions of the skull base and craniocervical junction. Neurosurgery Q 3:61–82

    Google Scholar 

  86. Eleraky MA, Masferrer R, Sonntag VK (1998) Posterior atlantoaxial facet screw fixation in rheumatoid arthritis. J Neurosurg 89:8–12

    Article  PubMed  CAS  Google Scholar 

  87. El-Khoury GY, Wener MH, Menezes AH, Dolan KD, Kathol MEH (1980) Cranial settling in rheumatoid arthritis. Radiology 137:637–642

    PubMed  CAS  Google Scholar 

  88. Finkelstein JA, Chapman JR, Mirza S (1999) Occult vertebral fractures in ankylosing spondylitis. Spinal Cord 37(6):444–447

    Article  PubMed  CAS  Google Scholar 

  89. Graham B, Van Peteghem PK (1989) Fractures of the spine in ankylosing spondylitis. Diagnosis, treatment, and complications. Spine 14(8):803–807

    Article  PubMed  CAS  Google Scholar 

  90. Huang RC, Girardi FP, Poynton AR et al (2003) Treatment of multilevel cervical spondylotic myeloradiculopathy with posterior decompression and fusion with lateral mass plate fixation and local bone graft. J Spinal Disord Tech 16:123–129

    Article  PubMed  Google Scholar 

  91. Magerl F, Seemann PS (1985) Stable posterior fusion of the atlas and axis by transarticular screw fixation. In: Kehr P, Weidner A (eds) Cervical spine. Springer, New York, pp 322–327

    Google Scholar 

  92. Matsunaga S, Sakou T, Sunahara N et al (1997) Biomechanical analysis of buckling alignment of the cervical spine: predictive value for subaxial subluxation after occipitocervi-cal fusion. Spine 22:765–771

    Article  PubMed  CAS  Google Scholar 

  93. Moskovich R, Crockard HA, Shott S et al (2000) Occipitocervical stabilization for myelopathy in patients with rheumatoid arthritis. J Bone Joint Surg Am 82A: 349–365

    Google Scholar 

  94. Paus AC, Steen H, Røislien J, Mowinckel P, Teigland J (2008) High mortality rate in rheumatoid arthritis with sub-luxation of the cervical spine: a cohort study of operated and nonoperated patients. Spine 33(21):2278–2283

    Article  PubMed  Google Scholar 

  95. Ronkainen A, Niskanen M, Auvinen A, Aalto J, Luosujarvi R (2006) Cervical spine surgery in patients with rheumatoid arthritis: longterm mortality and its determinants. J Rheumatol 33:517–522

    PubMed  Google Scholar 

  96. Stanley D, Laing RJ, Forster DM et al (1994) Posterior decompression and fusion in rheumatoid disease of the cervical spine: redressing the balance. J Spinal Disord 7:439–443

    Article  PubMed  CAS  Google Scholar 

  97. Szpalski M, Gunzburg R (2002) Surgical therapy and spinal inflammatory disease. Best Practice Res Clin Rheum 16(1):141–154

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Alberto Di Martino .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Martino, A.D., Denaro, L., Longo, U.G., Denaro, V. (2010). Pitfalls Related to Inflammatory Disorders. In: Denaro, L., D'Avella, D., Denaro, V. (eds) Pitfalls in Cervical Spine Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85019-9_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-85019-9_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-85018-2

  • Online ISBN: 978-3-540-85019-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics