Abstract
There is a wide range of highly significant scientific problems which on appropriate physical scales can be formulated as partial differential equations defined on so-called complex domains. Such complex domains often occur when material is transported through an environment of high geometrical complexity, for example porous media, domains with many obstacles, or membrane systems that are folded in a topologically complex configuration. The latter often occurs in cell biology, where the biological membranes inside the cell are strikingly topologically complex. In addition the medium in which, for example, proteins diffuse in the cell nucleus, is a complex porous media type of environment as many macro-molecules and protein-DNA complexes like the chromatin form a highly irregular structure in which many bio-molecular interactions occur. The distribution of biomolecules inside cells and tissues, their over-abundance or absence in metabolism, signalling etc., is the cause of many human diseases, therefore numerical simulations will be essential for future diagnostic abilities. Under appropriate assumptions the resulting molecular transport can be formulated as a PDE (Partial Differential Equation). The first challenge for any numerical discretisation is the generation of a cover for the underlying computational domain. Here, the mesh free Partition of Unity Method (PUM) offers a number of new degrees of freedom, as patches can be shifted, their size increased or diminished, with no need to create a non-overlapping cover at all times as is characteristic for traditional Finite Element and Finite Volume discretisations. Further advances in cover creation algorithms as discussed in this paper will allow the routine simulation of problems on domains with more complex geometries than have been treatable before.
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References
I. Babuška, U. Banerjee, and J. E. Osborn, Meshless and Generalized Finite Element Methods: A Survey of Some Major Results, Meshfree Methods for Partial Differential Equations (M. Griebel and M. A. Schweitzer, eds.), Lecture Notes in Computational Science and Engineering, vol. 26, Springer, 2002, pp. 1–20.
Ainsworth, Mark and Oden, J. Tinsley (1993). A unified approach to a posteriori error estimation using element residual methods. Numerische Mathematik, 65(1)
Babuška and J. M. Melenk, The partition of unity method, Internat. J. Numer. Methods Engrg., 40(4), (1997), 727–758.
Belytschko, T., Y. Y. Lu, and L. Gu, Element-free Galerkin methods, Int. J. Numer. Meth. Engrg. 37 (1994), 229–256.
Bouchekhima, A.-N., Frigerio, L., and Kirkilionis, M. A. (2007). Geometric Quantification of the Plant Endoplasmatic Reticulum. Warwick Preprint 11/2007. Submitted to Journal of Microscopy.
Costa, M., Marchi, M., Cardarelli, F., Roy, A., Beltram, F., Maffei, L. and Ratto, G.M., Dynamic regulation of ERK2 nuclear, translocation and mobility in living cells, Journal of Cell Science 119, pp. 4952–4963, 2006.
Domijan, M. and Kirkilionis, M. (2007). Bistability and Oscillations in Chemical Reaction Networks. Warwick Preprint 04/2007. Submitted to Journal of Mathematical Biology.
Domijan, M. and Kirkilionis, M. (2007). Graph Theory and Qualitative Analysis of Reaction Networks. Warwick Preprint 13/2007. Accepted: Networks and Heterogeneous Media, 2008.
Eigel, M., E. George, and M. Kirkilionis, A Meshfree Partition of Unity Method for Diffusion Equations on Complex Domains, Warwick Preprint:10/2007. Submitted to IMA J. Num. Anal.
Gerlich, D. and Ellenberg, J., 4D imaging to assay complex dynamics in live specimens. Nat Cell Biol, Vol. Suppl, pp. S14–S19, 2003.
Goodwin, J. S. and Kenworthy, A. K, Photobleaching approaches to investigate diffusional mobility and trafficking of Ras in living cells. Methods Cell Biol, Vol. 37, pp. 154–164, 2005.
Griebel, M. and Schweitzer, M.A., A Particle-partition of unity method. II. Efficient cover construction and reliable integration, SIAM J. Sci. Comput., 23(5) (2002), 1655–1682 (electronic).
McNally, J. G., Quantitative FRAP in analysis of molecular binding dynamics in vivo. Methods Cell Biol, Vol. 85, pp. 329–351, 2008.
Robinson, C. V., Sali, A., and Baumeister, W. (2007). The molecular sociology of the cell. Nature, 450(7172), 973–982
Sbano, L. and Kirkilionis, M. (2007). Molecular Systems with Infinite and Finite Degrees of Freedom. Part I: Continuum Approximation. Warwick Preprint 05/2007. Submitted to J. Math. Biol.
Sbano, L. and Kirkilionis, M. (2007). Molecular Systems with Infinite and Finite Degrees of Freedom. Part II: Deterministic Dynamics and Examples. Warwick Preprint 07/2007. Submitted to J. Math. Biol.
Sbano, L. and Kirkilionis, M. (2007). Multiscale Analysis of Reaction Networks. Warwick Preprint 12/2007.
Tian, R., G. Yagawa, H. Terasaka, Linear dependence problems, of partition of unity-based generalized FEMs, Comput. Methods Appl. Mech. Engrg., 195 (2006), 4768–4782.
Weiss, M.; Hashimoto, H. and Nilsson, T. Anomalous protein diffusion in living cells as seen by fluorescence correlation spectroscopy. Biophys J, Vol. 84, pp. 4043–4052, 2003.
Ainsworth, M. and Tinsley, J., A Posteriori Error Estimation in Finite Element Analysis, John Wiley & Sons., 2000.
Braess, D., Finite elements: Theory, fast solvers, and applications in solid mechanics, Cambridge University Press, 2001.
Cioranescu, D. and Donato, P., An Introduction to homogenization. Oxford University Press, 1999.
Schweitzer, M.A., A parallel multilevel partition of unity method for elliptic partial differential equations, Lecture Notes in Computational Science and Engineering, vol. 29, Springer, 2003.
Strang, G. and Fix, G. J., An Analysis of the Finite Element Method, Prentice-Hall, 1973.
Griebel, M. and Schweitzer, M.A., (eds.), Meshfree Methods for Partial Differential Equations, Lecture Notes in Computational Science and Engineering, vol. 26, Springer, 2002.
Griebel, M. and Schweitzer, M.A., A Particle-Partition of Unity Method Part VII: Adaptivity, Lecture Notes in Computational Science and Engineering, vol. 57, Springer, 2007.
Griebel, M. and Schweitzer, M.A., (eds.), Meshfree Methods for Partial Differential Equations II, Lecture Notes in Computational Science and Engineering, vol. 43, Springer, 2005.
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Eigel, M., George, E., Kirkilionis, M. (2008). The Partition of Unity Meshfree Method for Solving Transport-Reaction Equations on Complex Domains: Implementation and Applications in the Life Sciences. In: Griebel, M., Schweitzer, M.A. (eds) Meshfree Methods for Partial Differential Equations IV. Lecture Notes in Computational Science and Engineering, vol 65. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79994-8_5
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