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Aquaporins pp 233-249 | Cite as

Role of Aquaporin-7 and Aquaporin-9 in Glycerol Metabolism; Involvement in Obesity

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Part of the Handbook of Experimental Pharmacology book series (HEP, volume 190)

The discovery of aquaporin (AQP) has had a great impact on life sciences. So far, 13 AQPs have been identified in human. AQP3, 7, 9, and 10 are subcategorized as aquaglyceroporins which permeabilize glycerol as well as water. Many investigators have demonstrated that AQPs play a crucial role in maintaining water homeostasis, but the physiological significance of some AQPs as a glycerol channel has not been fully understood. Adipocyte is considered to be a major source of glycerol which is one of substrates for hepatic gluconeogenesis. This review focuses on recent studies of glycerol metabolism through AQP7 and AQP9, and discusses the importance of glycerol channel in adipose tissues and liver.

Keywords

Microsomal Triglyceride Transfer Protein Hormone Sensitive Lipase Glycerol Kinase Glycerol Metabolism Peroxisome Proliferator Response Element 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  1. 1.Toshiyuki Hibuse Yamada-okaSuitaJapan
  2. 2.Toshiyuki Hibuse Department of Metabolic MedicineGraduate School of Medicine, Osaka UniversitySuitaJapan

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