Skip to main content

Herz- und Herz-Lungen-Transplantation

  • Chapter
Herzchirurgie
  • 8909 Accesses

Zusammenfassung

Ein chronisches Herzversagen aktiviert pathophysiologische Mechanismen, wobei dem Ren in-Angiotensin-Aldosteron-System und dem erhöhten Sympathikotonus zentrale Rollen zukommen. Eine intensive, mindestens mehrere Monate lang durchgeführte medikamentöse Therapie mit ACE-(Angiotensin-Converting-Enzym-)Inhibitoren oder Angiotensinrezeptorblockern ist deshalb Voraussetzung für die Indikationsstellung zur Herztransplantation; ß-Blocker, Aldosteronantagonisten und natürlich Diuretika komplettieren eine Kombinationstherapie, die individuell zugeschnitten, u. U. mehrmalig adjustiert und mit anderen Medikamenten wie Digitalis, Hydralazinen und Nitraten erweitert werden kann (Richtlinien der Internationalen Gesellschaft für Herz- und Lungentransplantation; Mehra et al. 2006a).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 309.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 399.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Aigner C, Winkler G, Jaksch P et al. (2005) Extended donor criteria for lung transplantation — a clinical reality. Eur J Cardiothorac Surg 27: 757–761

    Article  PubMed  Google Scholar 

  • Bailey L, Concepcion W, Shattuck H, Huang L (1986) Method of heart transplantation for treatment of hypoplastic left heart syndrome. J Thorac Cardiovasc Surg 92: 1–5

    CAS  PubMed  Google Scholar 

  • Bardy GH, Lee KL, Mark DB et al. (2005) Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med 352: 225–235

    Article  CAS  PubMed  Google Scholar 

  • Beizer FO, Southard JH (1988) Principles of solid-organ preservation by cold storage. Transplantation 21: 673–686

    Google Scholar 

  • Beyersdorf F (2004) Myocardial und endothelial protection for heart transplantation in the new millennium: Lessons learned and future directions. J Heart Lung Transplant 23: 657–665

    Article  PubMed  Google Scholar 

  • Boucek MM, Waltz DA, Edwards LB et al. (2006) Registry of the ISHLT: Ninth official pediatric heart transplantation report. J Heart Lung Transplant 25: 893–903

    Article  PubMed  Google Scholar 

  • Bretschneider HJ, Hübner G, Knoll D, Lohr B, Nordbeck H, Spieckermann PG (1975) Myocardial resistance and tolerance to ischemia: Physiological and biochemical basis. J Cardiovasc Surg 16: 241–260

    CAS  Google Scholar 

  • Chin C, Naftel D, Pahl E et al. (2006) Cardiac re-transplantation in pediatrics; A multi-institutional study. J Heart Lung Transplant 25: 1420–1424

    Article  PubMed  Google Scholar 

  • Collins GM, Wicomb WN (1983) Present status of kidney preservation for transplantation. J Heart Transplant 2: 94–103

    Google Scholar 

  • Dreyfus G, Jebara V, Mihaileanu S, Carpentier AF (1991) Total orthotopic heart transplantation: An alternative to the standard technique. Ann Thorac Surg 52: 1181–1184

    CAS  PubMed  Google Scholar 

  • Groetzner J, Meiser B, Landwehr P et al. (2004) Mycophenolate mofetil and sirolimus as calcineurin inhibitor-free immunosuppression for late cardiac-transplant recipients with chronic renal failure. Transplantation 77: 568–574

    Article  CAS  PubMed  Google Scholar 

  • Groetzner J, Reichart B, Roemer U et al. (2005) Cardiac transplantation in pediatric patients: Fifteen-year experience of a single center. Ann Thorac Surg 79: 53–61

    Article  PubMed  Google Scholar 

  • Gronda E, Bourge RC, Costanzo MR et al. (2006) Heart rhythm considerations in heart transplant candidates and considerations for ventricular assist devices: International Society for Heart and Lung Transplantation guidelines for the care of cardiac transplant candidates. J Heart Lung Transplant 25: 1043–1056

    Article  PubMed  Google Scholar 

  • Hölscher M, Groenewoud AF (1991) Current status of the HTK solution of Bretschneider in organ preservation. Transplant Proc 23: 2334–2337

    PubMed  Google Scholar 

  • Human PA, Holl J, Vosloo S et al. (1993) Extended cardiopulmonary preservation: University of Wisconsin solution versus Bretschneider’s cardioplegic solution. Ann Thor Surg 55: 1123–1130

    CAS  Google Scholar 

  • Kajihara N, Morita S, Tanoue Y et al. (2006) The UW solution has greater potential for longer preservation periods than the Celsior solution: comparative study for ventricular and coronary endothelial function after 24-h heart preservation. Eur J Cardiothorac Surg 29: 784–789

    Article  PubMed  Google Scholar 

  • Kobashigawa J, Miller L, Renlund D et al. (1998) A randomized active-controlled trial of mycophenolate mofetil in heart transplant recipients. Mycophenolate Mofetil Investigators. Transplantation 66; 507–515

    Article  CAS  PubMed  Google Scholar 

  • Kobashigawa JA, Miller LW, Russell SD et al.; Study Investigators (2006) Tacrolimus with mycophenolate mofetil (MMF) or sirolimus vs. cyclosporine with MMF in cardiac transplant patients: 1-year report. Am J Transplant 6: 1377–1386

    Article  CAS  PubMed  Google Scholar 

  • Losman JG, Barnard CN, Barclay TD (1977) Hemodynamic evaluation of left ventricular bypass with a homologous cardiac graft. J Thorac Cardiovasc Surg 74: 695–708

    CAS  PubMed  Google Scholar 

  • Lower RR, Dong E, Shumway NE (1965) Long-term survival of cardiac homografts. Surgery 58: 110–119

    CAS  PubMed  Google Scholar 

  • Lower RR, Shumway NE (1960) Studies on the orthotopic homotrans-plantations of the canine heart. Surg Forum 11: 18–19

    CAS  PubMed  Google Scholar 

  • Mehra MR, Jessup M, Gronda E, Costanzo MR (2006a) Rationale and process: International Society for Heart and Lung Transplantation guidelines for the care of cardiac transplant candidates. J Heart Lung Transplant 25: 1003–1024

    Article  Google Scholar 

  • Mehra MR, Kobashigawa J, Starling R et al. (2006b) Listing criteria for heart transplantation: International Society for Heart and Lung Transplantation guidelines for the care of cardiac transplant candidates. J Heart Lung Transplant 25: 1024–1042

    Article  PubMed  Google Scholar 

  • Meiser B, Kaczmarek I, Mueller M et al. (2007) Low dose Tacrolimus/Sirolimus and steroid withd rawal in heart recipients is highly efficacious. J Heart Lung Transplant, in press

    Google Scholar 

  • Meiser B, Reichart B, Adamidis I, Ueberfuhr P, Kaczmarek I (2005) First experience with de novo calcineurin-inhibitor-free immunosuppression following cardiac transplantation. Transplantation 5: 827–831

    Article  Google Scholar 

  • Meiser BM (2005a) The best dosing of initial tacrolimus applications is trough level adapted. Transplantation 79: 10–11

    Article  CAS  PubMed  Google Scholar 

  • Meiser BM (2005b) Therapeutic drug monitoring of mycophenolic acid in cardiac transplant recipients: Does it make sense? Curr Opin Organ Trans 10: 350–354

    Article  Google Scholar 

  • Meiser, BM, Groetzner J, Kaczmarek I et al. (2004) Tacrolimus or cyclosporine — which is the better partner for mycophenolate mofetil in heart transplant recipients? Tansplantation 78: 591–598

    Article  CAS  Google Scholar 

  • Meiser BM, Pfeiffer M, Schmidt D et al. (1999) Combination therapy with tacrolimus and mycophenolate mofetil following cardiac transplantation: Importance of mycophenolic acid therapeutic drug monitoring. J Heart Lung Transplant 18: 143–149

    Article  CAS  PubMed  Google Scholar 

  • Meiser BM, Überfuhr P, Fuchs A et al. (1998) Single-center randomized trial comparing tacrolimus (FK506) and cyclosporine in the prevention of acute myocardial rejection. J Heart Lung Transplant 17: 782–788

    CAS  PubMed  Google Scholar 

  • Menasche P, Termingnon JL, Pradier F et al. (1994) Experimental evaluation of Celsior, a new heart preservation solution. Eur Cardiothorac Surg 8: 207–213

    Article  CAS  Google Scholar 

  • Michel P, Vial R, Rodriguez C, Ferrara R (2002) A comparative study of the most widely used solutions for cardiac graft preservation during hypothermia. J Heart Lung Transplant 21: 1030–1039

    Article  PubMed  Google Scholar 

  • Moss AJ, Zareba W, Hall WJ et al. (2002) Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med 346: 877–883

    Article  PubMed  Google Scholar 

  • Müller C, Fürst H, Reichenspurner H, Briegel J, Groh J, Reichart B (1999) Lung procurement by low-potassium, dextran and the effect on preservation injury. Transplantation 68: 1139–1143

    Article  PubMed  Google Scholar 

  • Novitzky D, Cooper DKG, Lanza RP, Barnard CN (1985) Further cardiac transplant procedures in patients with heterotopic heart transplants. Ann Thorac Surg 39: 149–154

    Article  CAS  PubMed  Google Scholar 

  • Novitzky D, Wicomb WN, Cooper DKC, Rose AG, Fraser RC, Barnard CN (1984) Electrocardiographic, haemodynamic and endocrine changes occuring during experimental brain death in the Chacma baboon. J Heart Transplant 4: 63–69

    Google Scholar 

  • Pahl E, Naftel DC, Kuhn MA et al. (2005) The impact and outcome of transplant coronary artery disease in a pediatric population: A 9-year multi-institutional study. J Heart Lung Transplant 24: 945–951

    Article  Google Scholar 

  • Patterson GA, Cooper JD (1988) Status of lung transplantation. Surg Clin North Am 68: 545–558

    CAS  PubMed  Google Scholar 

  • Reichart B, Meiser B, Vigano M et al. (1998) European Multicenter Tacrolimus (FK506) Heart Pilot Study: one-year results — European Tacrolimus Multicenter Heart Study Group. J Heart Lung Transplant 17: 775–781

    CAS  PubMed  Google Scholar 

  • Reitz BA, Burton NA, Jamieson SW et al. (1980) Heart and lung transplantation, autotransplantation and allotransplantation in primates with extended survival. J Thorac Cardiovasc Surg 80: 360–372

    CAS  PubMed  Google Scholar 

  • Rinaldi M, Pellegrini C, Martinelli L et al. (1997) FK506 effectiveness in reducing acute rejection after heart transplantation: a prospective randomized study. J Heart Lung Transplant 16: 1001–1010

    CAS  PubMed  Google Scholar 

  • Rosenthal D, Chrisant MRK, Edens E et al. (2004) ISHLT: Practice guidelines for management of heart failure in children. J Heart Lung Transplant 23: 1313–1333

    Article  PubMed  Google Scholar 

  • Ross M, Kouretas P, Gamberg P et al. (2006) Ten-and 20-year survivor of pediatric orthotopic heart transplantation. J Heart Lung Transplant 25: 261–270

    Article  PubMed  Google Scholar 

  • Sarsam MA, Campbell CS, Yonan NA, Deiraniya AK, Rahman AN (1993) An alternative surgical technique in orthotopic cardiac transplantation. J Card Surg 8: 344–349

    Article  CAS  PubMed  Google Scholar 

  • Shaw LM, Holt DW, Oellerich M, Meiser B, van Gelder T (2001) Current issues in therapeutic drug monitoring of mycophenolic acid: report of a roundtable discussion. Ther Drug Monit 23: 305–315

    Article  CAS  PubMed  Google Scholar 

  • Taylor DO, Barr ML, Meiser BM, Pham SM, Mentzer RM, Gass AL (2001) Suggested guidelines for the use of tacrolimus in cardiac transplant recipients. J Heart Lung Transplant 20: 734–738

    Article  CAS  PubMed  Google Scholar 

  • Taylor DO, Barr ML, Radovancevic B et al. (1999) A randomized, multi-center comparison of tacrolimus and cyclosporine immunosup-pressive regimens in cardiac transplantation: decreased hyperlipidemia and hypertension with tacrolimus. J Heart Lung Transplant 18: 336–345

    Article  CAS  PubMed  Google Scholar 

  • Taylor DO, Edwards LB, Boucek MM et al. (2007) Registry of the International Society for Heart and Lung Transplantation: Twenty-fourth official adult heart transplantation report. J Heart Lung Transplant 26: 769–781

    Article  PubMed  Google Scholar 

  • van Gelder T, Meur YL, Shaw L et al. (2006) Therapeutic drug monitoring of mycophenolate mofetil in transplantation. Ther Drug Monit 28: 145–154

    Article  PubMed  CAS  Google Scholar 

  • Wenke K, Meiser B, Thiery J, Reichart B (2005) Impact of simvastatin therapy after heart transplantation an 11-year prospective evaluation. Herz 30: 431–432

    Article  PubMed  Google Scholar 

  • Yacoub MH, Banner NR, Khaghani A et al. (1990) Heart-lung transplantation for cystic fibrosis and subsequent domino heart transplantation. J Heart Transplant 9: 459–466; discussion: 466–467

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Reichart, B., Meiser, B. (2010). Herz- und Herz-Lungen-Transplantation. In: Herzchirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79713-5_32

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-79713-5_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-79712-8

  • Online ISBN: 978-3-540-79713-5

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics