Merkel Cell Carcinoma

  • Martina UlrichEmail author
  • Jean Kanitakis

Core Messages

  • Merkel cell carcinoma (MCC), also known as primary neuroendocrine skin carcinoma or Merkel cell tumor, is a cutaneous malignancy of neuroendocrine origin, first described by Toker in 1972. Although MCC is rare, it has been shown to have a higher mortality rate than malignant melanoma with a 5-year disease-specific survival rate of 64% [1]. During the past two decades, the incidence of MCC reportedly increased threefold (from 0.15/100,000 in 1986 to 0.44/100,000 in 2001), representing an annual percentage incidence increase of 8% [2]. The increasing incidence, the aggressive behavior of this malignancy, the unknown etio-pathogenesis, and the paucity of options for the treatment of advanced disease call for the need of optimal, standardized management of this neoplasm.


Sentinel Lymph Node Biopsy Small Cell Lung Cancer Merkel Cell Carcinoma Wide Local Excision Isolate Limb Perfusion 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Klinik für Dermatologie, Allergologie und VenerologieCharité – Universitätsmedizin Berlin, HauttumorzentrumBerlinGermany

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