Merkel cell carcinoma (MCC), also known as primary neuroendocrine skin carcinoma or Merkel cell tumor, is a cutaneous malignancy of neuroendocrine origin, first described by Toker in 1972. Although MCC is rare, it has been shown to have a higher mortality rate than malignant melanoma with a 5-year disease-specific survival rate of 64% . During the past two decades, the incidence of MCC reportedly increased threefold (from 0.15/100,000 in 1986 to 0.44/100,000 in 2001), representing an annual percentage incidence increase of 8% . The increasing incidence, the aggressive behavior of this malignancy, the unknown etio-pathogenesis, and the paucity of options for the treatment of advanced disease call for the need of optimal, standardized management of this neoplasm.
KeywordsSentinel Lymph Node Biopsy Small Cell Lung Cancer Merkel Cell Carcinoma Wide Local Excision Isolate Limb Perfusion
- 4.Miller R, Rabkin C (1998) Merkel cell carcinoma and melanoma: etiological similarities and differences. Cancer Epidemiol Biomarkers Prev 8:153–158Google Scholar
- 13.Hausschild A, Garbe C (1998) Cutaneous neuroendocrine carcinoma (Merkel cell carcinoma). Quality Assurance Committee of the German Society of Dermatology and the Professional Organization of German Dermatologists e. V. Hautarzt 48(suppl 1):S27–29Google Scholar
- 26.Jabbour J, Cumming R, Scolyer RA et al (2007) Merkel cell carcinoma: assessing the effect of wide local excision, lymph node dissection, and radiotherapy on recurrence and survival in early stage disease- results from a review of 82 consecutive cases diagnosed between 1992 and 2004. Ann Surg Oncol 14:1943–1952PubMedCrossRefGoogle Scholar