Abstract
Infections in solid organ transplant recipients continue to be a significant source of morbidity and mortality. More than 80% of recipients develop at least one infection during the first year [16]. Kidney transplant recipients have the lowest risk of infection as compared to lung, liver, and heart allograft recipients, and this is likely related to the more elective nature of the surgery and better overall status of the patient prior to transplantation. Infections in this patient population, however, can lead to graft dysfunction, allograft rejection, alterations in immune status, and affect the overall transplant outcome [11]. Moreover, chronic graft rejection will necessitate more rigorous immunosuppression which will, in turn, increase the risk of developing infections with immunomodulating viruses [16]. There is thus a fine balance between developing the adequate immunosuppressive regimen that will prevent allograft rejection while at the same time not posing a significant risk for infection.
Keywords
- Renal Transplant Recipient
- Cerebral Spinal Fluid
- Renal Transplant Patient
- Infectious Mononucleosis
- Solid Organ Transplant Recipient
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Adami, J., Gabel, H., Lindelof, B., et al.: Cancer risk following organ transplantation: a nationwide cohort study in Sweden. Br. J. Cancer 89(7), 1221–1227 (2003)
Asberg, A., Humar, A., Rollag, H., et al.: Oral valganciclovir is noninferior to intravenous ganciclovir for the treatment of cytomegalovirus disease in solid organ transplant recipients. Am. J. Transplant. 7(9), 2106–2113 (2007)
Bohl, D.L., Brennan, D.C.: BK virus nephropathy and kidney transplantation. Clin. J. Am. Soc. Nephrol. 2 Suppl 1, S36–S46 (2007)
Brennan, D.C.: Cytomegalovirus in renal transplantation. J. Am. Soc. Nephrol. 12(4), 848–855 (2001)
Caillard, S., Agodoa, L.Y., Bohen, E.M., Abbott, K.C.: Myeloma, Hodgkin disease, and lymphoid leukemia after renal transplantation: characteristics, risk factors and prognosis. Transplantation 81(6), 888–895 (2006)
Cruzado, J.M., Gil-Vernet, S., Ercilla, G., et al.: Hepatitis C virus-associated membranoproliferative glomerulonephritis in renal allografts. J. Am. Soc. Nephrol. 7(11), 2469–2475 (1996)
Farrugia, E., Schwab, T.R.: Management and prevention of cytomegalovirus infection after renal transplantation. Mayo Clin. Proc. 67(9), 879–890 (1992)
Fishman, J.A.: Pneumocystis carinii and parasitic infections in transplantation. Infect. Dis. Clin. N. Am. 9(4), 1005–1044 (1995)
Fishman, J.A., Rubin, R.H.: Infection in organ-transplant recipients. N Engl J. Med. 338(24), 1741–1751 (1998)
Khoury, J.A., Storch, G.A., Bohl, D.L., et al.: Prophylactic versus preemptive oral valganciclovir for the management of cytomegalovirus infection in adult renal transplant recipients. Am. J. Transplant. 6(9), 2134–2143 (2006)
Kubak, B., Maree, C.L., Pegues, D., Hwang, A.: Infections in kidney transplantation. Handbook of kidney transplantation 4th ed. Ed Danovitch G, 2004. Lippincott Williams & Wilkins, Philadelphia
Morales, J.M.: Hepatitis C virus infection and renal disease after renal transplantation. Transplant. Proc. 36(3), 760–762 (2004)
Nalesnik, M.A., Makowka, L., Starzl, T.E.: The diagnosis and treatment of posttransplant lymphoproliferative disorders. Curr. Probl. Surg. 25(6), 367–472 (1988)
Penn, I.: Cancers complicating organ transplantation. N Engl J. Med. 323(25), 1767–1769 (1990)
Roth, D., Cirocco, R., Zucker, K., et al.: De novo membranoproliferative glomerulonephritis in hepatitis C virus-infected renal allograft recipients. Transplantation 59(12), 1676–1682 (1995)
Rubin, R.H.: Infectious disease complications of renal transplantation. Kidney Int. 44(1), 221–236 (1993)
Swinnen, L.J., Costanzo-Nordin, M.R., Fisher, S.G., et al.: Increased incidence of lymphoproliferative disorder after immunosuppression with the monoclonal antibody OKT3 in cardiac-transplant recipients. N Engl J. Med. 323(25), 1723–1728 (1990)
Waldman, M., Kopp, J.B.: Parvovirus-B19-associated complications in renal transplant recipients. Nat. Clin. Pract. Nephrol. 3(10), 540–550 (2007)
Winston, D.J., Emmanouilides, C., Busuttil, R.W.: Infections in liver transplant recipients. Clin. Infect. Dis. 21, 1077–1089 (1995). quiz 1090–1071
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© 2009 Springer Berlin Heidelberg
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Ghoussoub, R., Brennan, D.C. (2009). Clinical Aspects of Infection. In: Liapis, H., Wang, H. (eds) Pathology of Solid Organ Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79343-4_3
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DOI: https://doi.org/10.1007/978-3-540-79343-4_3
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