Acute Skin Failure

  • Laurence Valeyrie-Allanore
  • Saskia Oro
  • Jean-Claude Roujeau
  • Widespread skin diseases can be life-threatening.

  • Skin is much more than an inert barrier.

  • Skin contributes to important functions including thermoregulation, metabolism, innate, and acquired immune defense.

  • Skin failure can result from several dermatological diseases.

  • A few easy symptomatic measures can improve rapidly the systemic consequences from skin failure.


Atopic Dermatitis Stratum Corneum Toxic Epidermal Necrolysis Bullous Pemphigoid Cutaneous Blood 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Roujeau J-C, Revuz J. Intensive care in dermatology. In Champion RH, Pye RJ (eds.) Rec Adv Dermatol 1990;8:85–99Google Scholar
  2. 2.
    Braff MH, Bardan A, Nizet V, Gallo RL. Cutaneous defense mechanisms by antimicrobial peptides. J Invest Dermatol 2005;125:9–13PubMedCrossRefGoogle Scholar
  3. 3.
    Wang B, Amerio P, Sauder DN. Role of cytokines in epidermal Langerhans cell migration. J Leukoc Biol 1999;66:33–9PubMedGoogle Scholar
  4. 4.
    Udey MC. Langerhans cells on guard in the epidermis: poised to dSEARCH and…?. J Invest Dermatol 2006; 126:705–7PubMedCrossRefGoogle Scholar
  5. 5.
    Reilly TP, Lash LH, Doll MA, Hein DW, Woster PM, Svensson CK. A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions. J Invest Dermatol 2000;114:1164–73PubMedCrossRefGoogle Scholar
  6. 6.
    Roosterman D, Goerge T, Schneider SW, Bunnett NW, Steinhoff M. Neuronal control of skin function: the skin as a neuroimmunoendocrine organ. Physiol Rev 2006;86:1309–79PubMedCrossRefGoogle Scholar
  7. 7.
    Kelemen JJ 3rd, Cioffi WG Jr., Mason AD Jr., Mozingo DW, McManus WF, Pruitt BA Jr. Effect of ambient temperature on metabolic rate after thermal injury. Ann Surg 1996;223:406–12PubMedCrossRefGoogle Scholar
  8. 8.
    Choileain NN, MacConmara M, Zang Y, Murphy TJ, Mannick JA, Lederer JA. Enhanced regulatory T cell activation is an element of the host response to injury. J Immunol 2006;176:225–36Google Scholar
  9. 9.
    Bagot M, Charue D, Heslan M, Wechsler J, Roujeau JC, Revuz J. Impaired antigen presentation in toxic epidermal necrolysis. Arch Dermatol 1993;129:721–7PubMedCrossRefGoogle Scholar
  10. 10.
    Barber RC, Chang LY, Arnoldo BD, Purdue GF, Hunt JL, Horton JW, Aragaki CC. Innate immunity SNPs are associated with risk for severe sepsis after burn injury. Clin Med Res 2006; 4:250–5PubMedCrossRefGoogle Scholar
  11. 11.
    Roujeau J-C, Lock C, Bastuji-Garin S, Mhalla S, Enginger V, Bernbard P. High number of deaths in elderly patients with extensive bullous pemphigoid. Arch Dermatol 1998;134:465–9PubMedCrossRefGoogle Scholar
  12. 12.
    Joly P, Benichou J, Lock C et al. Predictors of survival for patients with bullous pemphigoid. Arch Dermatol 2005;141:691–8PubMedCrossRefGoogle Scholar
  13. 13.
    Sigurdsson V, Toonstra J, Hezemans-Boer M, van Vloten WA. Erythroderma. A clinical and follow-up study of 102 patients, with special emphasis on survival. J Am Acad Dermatol 1996;35:53–7PubMedCrossRefGoogle Scholar
  14. 14.
    Revuz J, Penso D, Roujeau J-C et al. Toxic epidermal necrolysis: clinical findings and prognosis factors in 87 patients. Arch Dermatol 1987;123:1160–5PubMedCrossRefGoogle Scholar
  15. 15.
    Ortega MR, Ganz T, Milner SM. Human beta defensin is absent in burn blister fluid. Burns 2000;26:724–6PubMedCrossRefGoogle Scholar
  16. 16.
    Bastuji-Garin S, Fouchard N, Bertocchi M, Revuz J, Roujeau J-C, Revuz J, et al. SCORTEN: a severity-of-illness score for toxic epidermal necrolysis. J Invest Dermatol 2000; 115:149–53PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Laurence Valeyrie-Allanore
    • 1
  • Saskia Oro
    • 2
  • Jean-Claude Roujeau
    • 1
  1. 1.Service de DermatologieCentre hospitalier universitaireFrance
  2. 2.Department of DermatologyHôpital Henri Mondor Université ParisXIICréteilFrance

Personalised recommendations