• Photosensitive disorders include idiopathic pho-todermatoses and photo-toxic and photo-allergic diseases related to identified photosensitizing molecules (also called chromophores).

  • Severe acute cutaneous reactions (from diffuse erythema to large bullous) are mainly observed with photo-toxic reactions caused by external agents (systemic or topically applied) which lower the threshold for abnormal UVR responses. Extensive burns have been particularly reported after therapeutic phototherapy or cosmetic use of psoralens for tanning.

  • Various photo-toxic and photo-allergic clinical reactions have been described with systemic drugs, especially with quinolones and propionic acid derivatives.

  • Diagnosing photosensitive disorders first depends on clinical examination with precise interrogation concerning possible sun exposure, and research of photosensitizing drugs.


Atopic Dermatitis Contact Dermatitis Tiaprofenic Acid Propionic Acid Derivative Extensive Burn 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Murphy GM (2001) Diseases associated with photosensitivity. J Photochem Photobiol B 64:93–98PubMedCrossRefGoogle Scholar
  2. 2.
    Murphy GM (2004) Investigation of photosensitive disorders. Photodermatol Photoimmunol Photomed 20:305–311PubMedCrossRefGoogle Scholar
  3. 3.
    Kalu PU, Myers S (2006) Recreational use of psoralens to fortify skin tanning. Burns 32:929–931PubMedCrossRefGoogle Scholar
  4. 4.
    Morison WL, Marwaha S, Beck L (1997) PUVA-induced phototoxicity: incidence and causes. J Am Acad Dermatol 36:183–185PubMedCrossRefGoogle Scholar
  5. 5.
    Herr H, Cho HJ, Yu S (2007) Burns caused by accidental overdose of photochemotherapy (PUVA). Burns 33:372–375PubMedCrossRefGoogle Scholar
  6. 6.
    Braye F, Latarjet J, Fovatier JL, Comparin JP, Tranchand P, Boucaud C (1997) Extensive burns caused by the abusive use of photosensitizing agents. J Burn Care Rehabil 18:321–325PubMedCrossRefGoogle Scholar
  7. 7.
    Lok C, Galizia JP, Labeille B, Cieslak C, Gontier MF, Turc Y, Schmidt JL, Fournier A, Pellerin P, Denoeux JP (1990) Artificial tanning and extensive burns. Ann Dermatol Venereol 117:809–810PubMedGoogle Scholar
  8. 8.
    Voss A, Leverkus M, Broecker EB, Goebeler M (2001) Topical psoralen photochemotherapy with lethal outcome. Arch Dermatol 137:383PubMedGoogle Scholar
  9. 9.
    Al-Qattan (2000) Pediatric burns induced by psoralens in Saudi Arabia. Burns 26:653–655PubMedCrossRefGoogle Scholar
  10. 10.
    Kaddu S, Kerl H, Wolf P (2001) Accidental bullous phototoxic reactions to bergamot aromatherapy oil. J Am Acad Dermatol 45:458–461PubMedCrossRefGoogle Scholar
  11. 11.
    Vuillamie M, Parienti JJ, Dompmartin A, Leroy D (2006) Incidence of drug-induced photosensitization during phototherapy. Ann Dermatol Venereol 133:333–339PubMedGoogle Scholar
  12. 12.
    Geary P (1996) Burns related to the use of psoralens as a tanning agent. Burns 22:636–637PubMedCrossRefGoogle Scholar
  13. 13.
    Nettelblad H, Vahlqvist C, Krysander L, Sjoberg F (1996) Psoralens used for cosmetic sun tanning: an unusual cause of extensive burn injury. Burns 22:636–637CrossRefGoogle Scholar
  14. 14.
    Cameron H, Dawe RS (2000) Photosensitizing drugs may lower the narrow-band ultraviolet B (TL-01) minimal erythema dose. Br J Dermatol 142:389–390PubMedCrossRefGoogle Scholar
  15. 15.
    Serrano G, Bonillo J, Aliaga A, Cuadra J, Pujol C, Pelufo C (1990) Piroxicam-induced photosensitivity and contact sensitivity to thiosalicylic acid. J Am Acad Dermatol 23:479–483PubMedCrossRefGoogle Scholar
  16. 16.
    Shea CR, Olack GA, Morrison H, Chen N, Hasan T (1993) Phototoxicity of lumidoxycycline. J Invest Dermatol 101:329–333PubMedCrossRefGoogle Scholar
  17. 17.
    Watanabe Y, Kawada A, Ohnishi Y, Tajima S, Ishibashi A (1999) Photosensitivity due to alprazolam with positive oral photochallenge test after 17 days administration. J Am Acad Dermatol 40:832–833PubMedCrossRefGoogle Scholar
  18. 18.
    Ferguson J (1995) Fluoroquinolone photosensitization: a review of clinical and laboratory studies. Photochem Photobiol 62:954–958CrossRefGoogle Scholar
  19. 19.
    Man I, Murphy J, Ferguson J (1999) Fluoroquinolone phototoxicity: a comparison of moxifloxacin and lomefloxacin in normal volunteers. J Antimicrob Chemother 43:77–82PubMedCrossRefGoogle Scholar
  20. 20.
    Scheife RT, Crammer WR, Decker EL (1993) Photosensitizing potential of Ofloxacin. Int J Dermatol 32:413–416PubMedCrossRefGoogle Scholar
  21. 21.
    Tokura Y, Nishijima T, Yagi H, Furukawa F, Takigawa M (1996) Photohaptenic properties of fluoroquinolones. Photochem Photobiol 64:838–844PubMedCrossRefGoogle Scholar
  22. 22.
    Guzzo C, Kaidbey K (1990) Persistent light reactivity from systemic quinine. Photodermatol Photoimmunol Photomed 7:166–168PubMedGoogle Scholar
  23. 23.
    Leroy D, Dompmartin A, Lorier E, Leport Y, Audebert C (1990) Photosensitivity induced by fenofibrate. Photodermatol Photoimmunol Photomed 7:136–138PubMedGoogle Scholar
  24. 24.
    Auffret N, Janssen F, Chevallier P, Guillemein R, Amrein C, Le Beller C (2006) Voriconazole photosensitivity: 7 cases. Ann Dermatol Venereol 133:330–332PubMedGoogle Scholar
  25. 25.
    McCarthy KL, Playford EG, Looke DF, Whitby M (2007) Severe photosensitivity causing multifocal squamous cell carcinomas secondary to prolonged voriconazole therapy. Clin Infect Dis 44:55–56CrossRefGoogle Scholar
  26. 26.
    Luu M, Lai SE, Patel J, Guitart J, Lacouture ME (2007) Photosensitive rash due to the epidermal growth factor receptor inhibitor erlotinib. Photodermatol Photoimmunol Photomed 23:42–45PubMedCrossRefGoogle Scholar
  27. 27.
    Guzzo C, Kaidby K (1995) Recurrent recall of sunburn by methotrexate. Photodermatol Photoimmunol Photomed 2:55–56Google Scholar
  28. 28.
    Hock-Leong E, Gil Y (2003) Photo recall phenomenon: an adverse reaction to taxanes. Dermatology 207:196–198CrossRefGoogle Scholar
  29. 29.
    Gould JW, Mercurio MG, Elmets CA (1995) Cutaneous photosensitivity diseases induced by exogenous agents. J Am Acad Dermatol 33:551–573PubMedCrossRefGoogle Scholar
  30. 30.
    Durieu C, Marguery MC, Giordano-Labadie F, Journe F, Loche F, Bazex J (2001) Photoaggravated contact allergy and contact photoallergy caused by ketoprofen: 19 cases. Ann Dermatol Venereol 128:1020–1024PubMedGoogle Scholar
  31. 31.
    Leonard F, Adamski H, Bonnevalle A, Bottlaender A, Bourrain JL, Goujon-Henry C, Leroy D (2005) The prospective multicenter study on standard photopatch tests by the French Society of Photodermatology from 1991 to 2001. Ann Dermatol Venereol 132:313–320PubMedCrossRefGoogle Scholar
  32. 32.
    Musa KA, Matxain JM, Eriksson LA (2007) Mechanism of photoinduced decomposition of Ketoprofen. J Med Chem 50:1735–1743PubMedCrossRefGoogle Scholar
  33. 33.
    Le Coz CJ, Bottlaender A, Scrivener JN, Santinelli F, Cribier BJ, Heid E (1998) Photocontact dermatitis from ketoprofen and tiaprofenic acid: cross-reactivity study in 12 consecutive patients. Contact Dermatitis 38:245–252PubMedCrossRefGoogle Scholar
  34. 34.
    Leroy D, Dompmartin A, Szczurko C, Michel M, Louvet S (1997) Photodermatitis from ketoprofen with cross-reactivity to fenofibrate and benzophenones. Photodermatol Photoimmunol Photomed 13:93–97PubMedGoogle Scholar
  35. 35.
    Zhang XM, Nakagawa M, Kawai K, Kawai K (1998) Erythema-multiforme-like eruption following photoallergic contact dermatitis from oxybenzone. Contact Dermatitis 38:43–44PubMedCrossRefGoogle Scholar
  36. 36.
    Kowalzick L, Ziegler H (2006) Photoallergic contact dermatitis from topical diclofenac in Solaraze gel. Contact Dermatitis 54: 348–349PubMedCrossRefGoogle Scholar
  37. 37.
    Bouyssou-Gauthier ML, Bedane C, Boulinguez S, Bonnetblanc JM (1999) Photosensitivity with sulfasalazopyridine hypersensitivity syndrome. Dermatology 198:388–390PubMedCrossRefGoogle Scholar
  38. 38.
    Murphy GM, White JR, Hawk JL (1990) Allergic airborne contact dermatitis to Compositae with photosensitivity — chronic actinic dermatitis in evolution. Photodermatol Photoimmunol Photomed 7:38–39PubMedGoogle Scholar
  39. 39.
    Wain EM, Smith CH (2006) Acute severe blistering in a 24-year-old man — diagnosis. Arch Dermatol 142: 1059–1064PubMedCrossRefGoogle Scholar
  40. 40.
    Leenutaphong V, Hölzle E, Plewig G (1990) Solar urticaria: studies on mechanisms of tolerance 122:601–606Google Scholar
  41. 41.
    Beattie PE, Dawe RS, Ibbotson SH, Ferguson J (2003) Characteristics and prognosis of idiopathic solar urticaria: a cohort of 87 cases. Arch Dermatol 139:1149–1154PubMedCrossRefGoogle Scholar
  42. 42.
    Shimauchi T, Kabashima K, Tokura Y (2007) Solar urticaria as a manifestation of Churg–Strauss syndrome. Clin Exp Dermatol 32:209–210PubMedCrossRefGoogle Scholar
  43. 43.
    Stinco G, Di Gaetano L, Rizzi C, Patrone P (2007) Leukocytoclastic vasculitis in urticaria induced by sun exposure. Photodermatol Photoimmunol Photomed 23:39–41PubMedCrossRefGoogle Scholar
  44. 44.
    Iwatsuki K, Masataka S, Takenobu Y (2006) Pathogenic link between hydroa vacciniforme and Epstein–Barr Virus-associated hematologic disorders. Arch Dermatol 142:587–595PubMedCrossRefGoogle Scholar
  45. 45.
    Hawk JL (2004) Chronic actinic dermatitis. Photodermatol Photoimmunol Photomed 20:312–314PubMedCrossRefGoogle Scholar
  46. 46.
    Creamer D, MacGregor JM, Hawk JLM (1998) Chronic actinic dermatitis occurring in young patients with atopic dermatitis. Br J Dermatol 139:1112–1113PubMedCrossRefGoogle Scholar
  47. 47.
    Russell SC, Dawe RS, Collins P, Man I, Ferguson J (1998) The photosensitivity dermatitis and actinic reticuloid syndrome (chronic actinic dermatitis) occurring in seven young atopic dermatitis patients. Br J Dermatol 138:496–501PubMedCrossRefGoogle Scholar
  48. 48.
    Menagé H du P, Hawk JL, White IR (1998) Sesquiterpene lactone mix contact sensitivity and its relationship to chronic actinic dermatitis: a follow-up study. Contact Dermatitis 39:119–122CrossRefGoogle Scholar
  49. 49.
    Belhadjali H, Marguery MC, Lamant L, Giordano-Labadie F, Bazex J (2003) Photosensitivity in Sweet's syndrome: two cases that were photoinduced and photoaggravated. Br J Dermatol 149:675–677PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • M. -T. Leccia
    • 1
  • J. -C. Beani
    • 1
  1. 1.Dermatologie, Pôle Pluridisciplinaire de Médecine, CHU Albert MichallonGrenoble cedexFrance

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