Acute Generalized Exanthematous Pustulosis

  • Alexis Sidoroff
  • AGEP, mostly caused by drugs, is characterized by the acute occurrence of numerous sterile pinhead-sized pustules on an oedematous erythema accompanied by fever and leucocytosis.

  • The drugs with the highest risk to cause AGEP are antibacterial agents like ampicillin/amoxicillin, and quinolones, pristinamycin, anti-infective sulfonamides, the antimycotic drug terbinafine, (hydroxy)chloroquine, and diltiazem, but a large number of other drugs as well as infections have been reported as triggers.

  • AGEP is an acute and sometimes severe reaction, but resolves quickly and without special treatment when the culprit drug is withdrawn.


Toxic Epidermal Necrolysis Pustular Psoriasis Acute Generalize Exanthematous Pustulosis Chromium Picolinate Culprit Drug 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2009

Authors and Affiliations

  • Alexis Sidoroff
    • 1
  1. 1.Department of Dermatology and VenereologyMedical University of InnsbruckInnsbruckAustria

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