Skip to main content

Building Block Oriented Synthesis

  • Chapter
Elements of Synthesis Planning
  • 2091 Accesses

Abstract

If substructures with special features (branches, stereogenic centers) of the target correspond to readily available starting materials, it is advisable to incorporate those as building blocks in the synthesis. Guidelines are given as to how to identify suitable building blocks.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 49.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 64.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. P. L. Stotter, R. E. Hornish, J. Am. Chem. Soc. 1973, 95, 4444–4446.

    Article  CAS  Google Scholar 

  2. K. Kondo, A. Negishi, K. Matsui, D. Tunemoto, S. Masamune, J. Chem. Soc., Chem. Commun. 1972, 1311–1312.

    Google Scholar 

  3. D. Seebach, H.-O. Kalinowski, Nachr. Chem. Tech. Lab. 1976, 24, 415–418.

    Google Scholar 

  4. S. Hanessian, Aldrichimica Acta 1989, 22, 3–14.

    CAS  Google Scholar 

  5. B. Giese, R. Rupaner, Synthesis 1988, 219–221.

    Google Scholar 

  6. H. H. Meyer, Liebigs Ann. Chem. 1977, 732–736.

    Google Scholar 

  7. K. Mori, Y.-B. Seu, Liebigs Ann. Chem. 1986, 205–209.

    Google Scholar 

  8. H. Kotsuki, I. Kadota, M. Ochi, J. Org. Chem. 1990, 55, 4417–4422.

    Article  CAS  Google Scholar 

  9. Y. Masaki, K. Nagata, Y. Serizawa, K. Kaji, Tetrahedron Lett. 1982, 23, 5553–5554.

    Article  CAS  Google Scholar 

  10. K. C. Nicolaou, T. Ohshima, S. Hosokawa, F. L. van Delft, D. Vourloumis, J. Y. Xu, J. Pfefferkorn, S. Kim, J. Am. Chem. Soc. 1998, 120, 8674–8680.

    Article  CAS  Google Scholar 

  11. S. M. Ceccarelli, U. Piarulli, C. Gennari, Tetrahedron 2001, 57, 8531–8542.

    Article  CAS  Google Scholar 

  12. X.-T. Chen, C. E. Gutteridge, S. K. Bhattacharya, B. Zhou, T. R. R. Pettus, T. Hascall, S. J. Danishefsky, Angew. Chem., Int. Ed. Engl. 1998, 37, 185–186. (Angew. Chem. 1998, 110, 195–197).

    Article  CAS  Google Scholar 

  13. J. W. Scott in Asymmetric Synthesis (Eds.: J. D. Morrison, J. W. Scott), Academic Press, New York, vol. 4, 1984, pp. 1–226.

    Google Scholar 

  14. S. Hanessian, J. Franco, B. Larouche, Pure. Appl. Chem. 1990, 62, 1887–1910.

    Article  CAS  Google Scholar 

  15. G. Just, C. Luthe, Can. J. Chem. 1980, 58, 1799–1805.

    Article  CAS  Google Scholar 

  16. R. W. Hoffmann, W. Ladner, Chem. Ber. 1983, 116, 1631–1642.

    Article  CAS  Google Scholar 

  17. R. Stürmer, Liebigs Ann. Chem. 1991, 311–313.

    Google Scholar 

  18. H. Redlich, W. Francke, Angew. Chem., Int. Ed. Engl. 1980, 19, 630–631. (Angew. Chem. 1980, 92, 640–641).

    Article  Google Scholar 

  19. H. Redlich, J. Xiang-jun, Liebigs Ann. Chem. 1982, 717–722.

    Google Scholar 

  20. P. M. Koskinen, A. M. P. Koskinen, Synthesis 1998, 1075–1091.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to R.W. Hoffmann .

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Hoffmann, R. (2009). Building Block Oriented Synthesis. In: Elements of Synthesis Planning. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79220-8_4

Download citation

Publish with us

Policies and ethics