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Natural Products in Cancer Chemoprevention and Chemotherapy

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Herbal Drugs: Ethnomedicine to Modern Medicine

Abstract

Medicinal plants are an important source of diverse chemical compounds that have been used for the past several centuries in the treatment of cancer. About 25% of drugs in the modern pharmacopoeia are derived from plants, including several anticancer drugs currently in clinical use such as vincristine, vinblastine, paclitaxel, podophyllotoxin, camptothecin and combretastatin. These natural products, their derivatives and analogues based on these drugs constitute an arsenal against various types of neoplasms. The traditional use of plants provides a lead for cancer chemopreventive molecules. The development of new derivatives from bioactive compounds of food origin has been a viable way to reduce toxicity and increase their effectiveness against cancer. The combined efforts of botanists, pharmacologists, chemists and biologists are required to discover new effective drugs to fight cancer. An evaluation of the mode of action of these bioactive molecules will be helpful in designing novel drugs targeting mitosis. This article discusses natural products currently in clinical use, and under clinical trials, for cancer chemotherapy and chemoprevention.

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References

  1. Demain AL, Zhang L (2005) Natural products and drug discovery. In: Zhang L, Demain AL (eds) Natural Products: Drug Discovery and Therapeutic Medicine. Humana,Totowa, NJ, p 3

    Google Scholar 

  2. Schippmann U, Leaman DJ, Cunnningham AB (2002) Biodiversity and the Ecosystem: Approaches in Agriculture, Forestry and Fisheries. 9th Regular Session of the Commission on Genetic Resources for Food and Agriculture. FAO, Rome, Italy 1

    Google Scholar 

  3. Anonymous (1994) Lancet 343:1513

    Google Scholar 

  4. Gupta R (1986) Integration of medicinal plants cultivation in forest and forest plantations of north-western Himalaya. In: Agroforestry Systems: A New Challenge. Indian Society of Tree Scientists, Solan, India, p 59

    Google Scholar 

  5. Van Wyk B-E, Wink M (2004) Medicinal Plants of the World. Briza, Pretoria, Briza

    Google Scholar 

  6. Merillon JM, Ramawat KG (2007) Biotechnology for medicinal plants: research need. In: Ramawat KG, Merillon JM (eds) Biotechnology: Secondary Metabolites, Plants and Microbes. Science Publishers, Enfield, NH, p 1

    Google Scholar 

  7. Ramawat KG, Goyal S (2008) Indian herbal drugs scenario in global perspectives. In: Ramawat KG, Merillon JM (eds) Bioactive Compounds and Medicinal Plants. Springer, Berlin Heidelberg New York, p 323

    Chapter  Google Scholar 

  8. Salim AA, Chin Y-W, Kinghorn AD (2008) Drug discovery from plants. In: Ramawat KG, Merillon JM (eds) Bioactive Compounds and Medicinal Plants. Springer, Berlin Heidelberg New York, p 1

    Chapter  Google Scholar 

  9. Ramawat KG (2007) Production of alkaloids. In: Ramawat KG, Merillon JM (eds) Biotechnology: Secondary Metabolites, Plants and Microbes. Science Publishers, Enfield, NH, p 179

    Google Scholar 

  10. Chin Y-W, Balunas MJ, Chai HB, Kinghorn AD (2006) AAPS J 8:E239

    CAS  Google Scholar 

  11. Wink M, Alfermann W, Franke R, Wetterauer B et al (2005) Plant Gen Resourc 3:90

    Article  CAS  Google Scholar 

  12. Taylor JLS, Rabe T, McGaw LJ, Jager AK, Staden JV (2001) Plant Growth Regul 34:23

    Article  CAS  Google Scholar 

  13. Issa AY, Volate SR, Wargovich MJ (2006) J Food Composit Analysis 19:405

    Article  CAS  Google Scholar 

  14. Parkin DM (2001) Lancet Oncol 2:533

    Article  CAS  Google Scholar 

  15. Jemal A, Muarray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, Feuer EJ, Thun MJ (2005) CA-A Cancer J Clin 55:10

    Google Scholar 

  16. Hanahan D, Weinberg RA (2000) Cell 100:57

    Article  CAS  Google Scholar 

  17. Deorukhkar A, Krishnan S, Sethi G, Aggarwal BB (2007) Expert Opin Investigat Drugs 16:1753

    Article  CAS  Google Scholar 

  18. Newman DJ, GM Cragg, KM Snader (2000) Nat Prod Rep 17:215

    Article  CAS  Google Scholar 

  19. Newman DJ, Cragg GM, Snader KM (2003) J Nat Prod 66:1022

    Article  CAS  Google Scholar 

  20. Balunas MJ, Kinghorn AD (2005) Life Sci 78:431

    Article  CAS  Google Scholar 

  21. Mann J (2002) Nat Rev 2:143

    Article  CAS  Google Scholar 

  22. Abdullaev FI (2002) Exp Biol Med 227:20

    CAS  Google Scholar 

  23. Tsao AS, Kim ES, Hong WK (2004) CA-A Cancer J Clin 54:150

    Google Scholar 

  24. Park EJ, Pezzuto JM (2002) Cancer Metastasis Rev 21:231

    Article  CAS  Google Scholar 

  25. Reddy L, Odhav B, Bhoola KD (2003) Pharmacol Therapeut 99:1

    Article  CAS  Google Scholar 

  26. Aggarwal BB, Shishodia S (2006) Biochem Pharmacol 71:1397

    Article  CAS  Google Scholar 

  27. Kelloff GJ, Crowell JA, Steele VE, Lubet RA, Malone WA, Boone CW, Kopelovich L, Hawk ET, Lieberman R, Lawrence JA, Ali L, Viner JL, Sigman CC (2000) J Nutr 130:467s

    CAS  Google Scholar 

  28. Greenwald P (2002) Br Med J 324:714

    Article  CAS  Google Scholar 

  29. Ramawat KG, Merillon JM (eds) (2008) Bioactive Compounds and Medicinal Plants. Springer, Berlin Heidelberg New York

    Google Scholar 

  30. Ferguson LR, Philpott M (2007) Curr Cancer Drug Targets 7:459

    Article  CAS  Google Scholar 

  31. Shukla S, Gupta S (2005) Nutr Cancer 53:18

    Article  CAS  Google Scholar 

  32. Soobrattee MA, Bahorun T, Aruoma OI (2006) Free Radicals Biol Med 27:19

    CAS  Google Scholar 

  33. Scalbert A, Johnson IT Saltmarsh M (2006) Am J Clin Nutr 81:215s

    Google Scholar 

  34. Gutteridge JMC, Halliwell B (1994) Oxford University Press, Oxford, UK

    Google Scholar 

  35. Cheynier V (2005) Am J Clin Nutr 81:223s

    CAS  Google Scholar 

  36. Kuntz S, Wenzel U, Daniel H (1999) Eur J Nutr 38:133

    Article  CAS  Google Scholar 

  37. Manach C, Williamson G, Morand C, Scalbert A, Remesy C (2005) Am J Clin Nutr 81:230s

    CAS  Google Scholar 

  38. Waffo–Teguo P, Stephanie K, Tristan R, Merillon JM (2008) Grapevine stilbenes and biological effects. In: Ramawat KG, Merillon JM (eds) Bioactive Compounds and Medicinal Plants. Springer, Berlin Heidelberg New York, p 25

    Chapter  Google Scholar 

  39. Vitrac X, Krissa S, Decendit A, Deffieux G, Merillon JM (2004) In: Ramawat KG (ed) Biotechnology of Medicinal Plants. Science Publishers, Enfield, NH, p 33

    Google Scholar 

  40. Shishodia S, Aggarwal BB (2006) Resveratrol: a polyphenol for all seasons. CRC Press/Taylor and Francis, Boca Raton, FL

    Google Scholar 

  41. Aggarwal BB, Bhardwaj A, Aggarwal RS et al (2004) Anticancer Res 24:2783

    CAS  Google Scholar 

  42. DeLorgeril M, Salen P (1998) Lancet 351:1440

    Article  CAS  Google Scholar 

  43. Renaud S, De Lorgeril M (1992) Lancet 339:1523

    Article  CAS  Google Scholar 

  44. Delmas D, Jannin B, Latruffe N (2005) Mol Nutr Food Res 49:377

    Article  CAS  Google Scholar 

  45. Delmas D, Lancon A, Colin D, Jannin B, Latruffe N (2006) Curr Drug Targets 7:423

    Article  CAS  Google Scholar 

  46. Henry-Vitrac C, Desmouliere A, Girard D, Merillon J-M, Krisa S (2006) Eur J Nutr 45:376

    Article  CAS  Google Scholar 

  47. Khan N, Afaq F, Saleem M et al (2006) Cancer Res 66:2500

    Article  CAS  Google Scholar 

  48. Pan MH, Lin CC, Lin JK, Chen WJ (2007) J Agric Food Chem 55:5030

    Article  CAS  Google Scholar 

  49. Kumar NB (2005) Evidence Based Integrative Med 2:13

    Article  Google Scholar 

  50. Dixon RA, Sumner LW (2003) Plant Physiol 131:878

    Article  CAS  Google Scholar 

  51. Lamartiniere CA (2006) http://handle.dtic.mil/100.2/ada463968

  52. Shim HY, Park JH, Paik HD, Nah SY, Kim DS, Han YS (2007) Anticancer Drugs 18:649

    Article  CAS  Google Scholar 

  53. Aggarwal BB, Shishodia S, Young-Joon S (2007) The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease. Springer, Berlin Heidelberg New York

    Google Scholar 

  54. Shishodia S, Sethi G, Aggarwal BB (2005) Ann NY Acad Sci 1056:206

    Article  CAS  Google Scholar 

  55. Shukla Y, Singh M (2007) Food Chem Toxicol 45:683

    Article  CAS  Google Scholar 

  56. Kim SO, Chun KS, Kundu JK, Surh YJ (2004) Biofactors 21:27

    Google Scholar 

  57. Bhutani M, Pathak AK, Nair AS et al (2007) Clin Cancer Res 13:3024

    Article  CAS  Google Scholar 

  58. Min JK, Han KY, Kim EC et al (2004) Cancer Res 64:644

    Article  CAS  Google Scholar 

  59. Senderowicz AM (2005) Prog Drug Res 63:183

    Article  CAS  Google Scholar 

  60. Milner JA (2006) Nutr Cancer 56:216

    Article  CAS  Google Scholar 

  61. Kim EC, Min JK, Kim TY, Lee SJ, Yang HO, Han S, Kim YM, Kwon YG (2005) Biochem Biophys Res Comm 335:300

    Article  CAS  Google Scholar 

  62. Newman DJ, Cragg GM (2005) The discovery of anticancer drugs from natural sources. In: Zhang L, Demain AL (eds) Natural Products: Drug Discovery and Therapeutic Medicine. Humana, Totowa, NJ, p 129

    Google Scholar 

  63. Strohl W (1997) Industrial antibiotics: today and the future. In: Strohl W (ed) Biotechnology of Antibiotics, 2nd edn. Dekker, New York, p 1

    Google Scholar 

  64. Bull AT, AC Ward, M Goodfellow (2000) Microbiol Mol Biol Rev 64:573

    Article  CAS  Google Scholar 

  65. Cragg GM, D Newman (2000) Exp Opin Invest Drugs 9:2783

    Article  CAS  Google Scholar 

  66. Butler MS (2005) Nat Prod Rep 22:162

    Article  CAS  Google Scholar 

  67. Lee KH (2004) J Nat Prod 67:273

    Article  CAS  Google Scholar 

  68. Purohit MC, Bahuguna R, Maithani UC, Purohit AN, Rawat MSM (1999) Curr Sci 77:1078

    CAS  Google Scholar 

  69. Nadeem M, Palni LMS, Kumar A, Nandi SK (2007) Planta Med 73:388

    Article  CAS  Google Scholar 

  70. Pandey H, Nandi SK, Kumar A, Palni UT, Palni LMS (2007) Acta Physiol Plant 29:121

    Article  CAS  Google Scholar 

  71. Giri A, Narasu ML (2000) Cytotechnol 34:17

    Article  CAS  Google Scholar 

  72. Handa SS, Chawla AS, Maninder A (1989) Fitoterapia 60:195

    CAS  Google Scholar 

  73. Altmann K-H, Gertsch J (2007) Nat Prod Rep 24:327

    Article  CAS  Google Scholar 

  74. Lee K-H (1999) J Biomed Sci 6:236

    CAS  Google Scholar 

  75. Gigant B, Wang C, Ravelli RB, Roussi F, Steinmetz MO, Curmi PA, Sobel A, Knossow M (2005) Nature 435:519

    Article  CAS  Google Scholar 

  76. Fahy J (2001) Curr Pharmaceut Design 7:1181

    Article  CAS  Google Scholar 

  77. Croteau R, Ketchum REB, Long RM, Kaspera R (2006) Phytochem Rev 5:75

    Article  CAS  Google Scholar 

  78. Schiff PB, Fant J, Horwitz S (1979) Nature 277:665

    Article  CAS  Google Scholar 

  79. Horwitz SB (2004) J Nat Prod 67:136

    Article  CAS  Google Scholar 

  80. Gueritte-Voegelein F, Guenard D, Lavelle F et al (1991) J Med Chem 34:992

    Article  CAS  Google Scholar 

  81. Wall ME, Wani MC (1996) J Ethnopharmacol 51:239

    Article  CAS  Google Scholar 

  82. Tabata H (2004) Adv Biochem Eng Biotechnol 7:1

    Google Scholar 

  83. Kintzios S (2008) Secondary metabolite production from plant cell cultures: the success stories of rosmarinic acid and taxol. In: Ramawat KG, Merillon JM (eds) Bioactive compounds and Medicinal Plants. Springer, Berlin Heidelberg New York, p 85

    Chapter  Google Scholar 

  84. Takeya K (2003) Plant tissue culture of taxoids. In: Itokawa H, Lee K-H (eds) Taxus-The Genus Taxus. Taylor & Francis, London, p 134

    Google Scholar 

  85. Tabata H (2006) Curr Drug Targets 7:453

    Article  CAS  Google Scholar 

  86. Wall ME, MC Wani, CE Cook, KH Palmer, AT McPhail, GA Sim (1966) J Am Chem Soc 88:3888

    Article  CAS  Google Scholar 

  87. Govindachari TR, Viswanathan N (1972) Indian J Chem 10:453

    CAS  Google Scholar 

  88. Duflos A, Kruczynski A, Barnet JM (2002) Curr Med Chem Anticancer Agents 2:55

    Article  CAS  Google Scholar 

  89. Plosker GL, Figgitt D (2003) Drugs 63:803

    Article  CAS  Google Scholar 

  90. Seidman AD (2003) Semin Oncol 30:6

    CAS  Google Scholar 

  91. Okouneva T, Hill BT, Wilson L, Jordan MA (2003) Mol Cancer Ther 2:427

    CAS  Google Scholar 

  92. Horwitz SB (1994) Nature 367:593

    Article  CAS  Google Scholar 

  93. Belani CP, Langer C (2002) Lung Cancer 38:13

    Article  Google Scholar 

  94. Fossella FV, Lynch T, Shepherd FA (2002) Lung Cancer 38:5

    Article  Google Scholar 

  95. Tozer GM, Kanthou C, Parkins CS, Hill SA (2002) Int J Exp Pathol 83:2

    Article  Google Scholar 

  96. Cirla A, Mann J (2003) Nat Prod Rep 20:558

    Article  CAS  Google Scholar 

  97. West CML, Price P (2004) Anticancer Drugs 15:179

    Article  CAS  Google Scholar 

  98. Hamel E, Lin CM, Plowman J et al (1996) Biochem Pharmacol 51:53

    Article  CAS  Google Scholar 

  99. Kantarjian HM, Talpaz M, Santini V, Murgo A, Cheson B, O’Brian SM (2001) Cancer 92:1591

    Article  CAS  Google Scholar 

  100. Kedei N, Lundberg DJ, Toth A, Welburn P, Garfield SH, Blumberg PM (2004) Cancer Res 64:3243

    Article  CAS  Google Scholar 

  101. Kamsteeg M, Rutherford T, Sapi E, et al (2003) Oncogene 22:2611

    Article  CAS  Google Scholar 

  102. Jia W, Yan H, Bu X, Liu G, Zhao Y (2004) J Clin Oncol 22:9663

    Google Scholar 

  103. Uma Shaanker R, Ramesha BT, Ravikanth G, Gunaga R, Vasudeva R, Ganeshaiah KN (2008) Chemical profiling of Nothapodytes nimmoniana for camptothecin, an important anticancer alkaloid: towards development of a sustainable production system. In: Ramawat KG, Merillon JM (eds) Bioactive Compounds and Medicinal Plants.e Springer, Berlin Heidelberg New York, p 197

    Chapter  Google Scholar 

  104. Shiraga T, Tozuka Z, Ishimura R, Kawamura A, Kagawama A (2005) Biol Pharm Bull 28:124

    Article  CAS  Google Scholar 

  105. Sandor V, Bakke S, Robey RW, Kang MH, Blagosklonny MV, Bender J, Brooks R, Piekarz RL, Tucker E, Figg WD, Chan KK, Goldspiel B, Fojo AT, Balcerzak SP, Bates SE (2002) Clin Cancer Res 8:718

    CAS  Google Scholar 

  106. Holwell SE, Cooper PA, Grosios K (2002) Anticancer Res 22:707

    CAS  Google Scholar 

  107. Bernier SG, Lazarus DD, Clark E et al (2004) Proc Natl Acad Sci USA 101:10768

    Article  CAS  Google Scholar 

  108. Chun E, Han CK, Yoon JH, Sim TB, Kim Y-K, Lee K-Y (2005) Int J Cancer 114:124

    Article  CAS  Google Scholar 

  109. Hayakawa Y, Rovero S, Forni G, Smyth MJ (2003) Proc Natl Acad Sci USA 100:9464

    Article  CAS  Google Scholar 

  110. Cragg GM, Newman DJ (2004) J Nat Prod 67:232

    Article  CAS  Google Scholar 

  111. Honore S, Kamath K, Braguer D, Wilson L, Briand C, Jordan MA (2003) Mol Cancer Ther 2:1303

    CAS  Google Scholar 

  112. Rajendran P, Jaggi M, Singh MK, Mukherjee R, Burman AC (2008) Invest New Drugs 26:25

    Article  CAS  Google Scholar 

  113. D’Incalci M, Brunelli D, Marangon E et al (2007) Curr Pharmaceut Design 13:2744

    Article  CAS  Google Scholar 

  114. Capdeville R, Buchdunger E, Zimmermann J, Matter A (2002) Nat Rev Drug Discovery 1:493

    Article  CAS  Google Scholar 

  115. Jordan MA, Wilson L (2004) Nat Rev Cancer 4:253

    Article  CAS  Google Scholar 

  116. Zhou J, Giannakakou P (2005) Curr Med Chem-Anticancer Agents 5:65

    Article  CAS  Google Scholar 

  117. Meijerman I, Beijnen JH, Schellens JHM (2006) Oncologist 11:742

    Article  CAS  Google Scholar 

  118. Sparreboom A, Cox MC, Acharya MR et al (2004) J Clin Oncol 22:2489

    Article  CAS  Google Scholar 

  119. Beijinen JH, Schellens JH (2004) Lancet Oncol 5:489

    Article  CAS  Google Scholar 

  120. Mathijssen RH, Verweij J, de Bruijn P et al (2002) J Natl Cancer Inst 94:1247

    CAS  Google Scholar 

  121. Raucy JL (2003) Drug Metab Dispos 31:533

    Article  CAS  Google Scholar 

  122. Brobst DE, Ding X, Creech KL et al (2004) J Pharmacol Exp Ther 310:528

    Article  CAS  Google Scholar 

  123. Owsley E, Chiang JY (2003) Biochem Biophys Res Commun 304:191

    Article  CAS  Google Scholar 

  124. Cordell GA (2002) Phytochem Rev 1:261

    Article  CAS  Google Scholar 

  125. Ackler JR, Tester WJ, Leighton JC (2005) J Clin Oncol 23:8171

    Google Scholar 

  126. Ying QL, Liu Y, Xuan T (2007) Curr Bioactive Comp 3:37

    Article  Google Scholar 

  127. Kelling J, Sullivan K, Wilson L, Jordan MA (2003) Cancer Res 63:2794

    CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Biomolecular Technology Department of Botany, M. L. Sukhadia University, Udaipur-313001, India

    K.G. Ramawat & Shaily Goyal

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  1. K.G. Ramawat
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  2. Shaily Goyal
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  1. Botany Dept, M.L. Sukhadia University, Udaipur-313002, India

    K.G. Ramawat (Prof. Dr.) (Prof. Dr.)

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Ramawat, K., Goyal, S. (2009). Natural Products in Cancer Chemoprevention and Chemotherapy. In: Ramawat, K. (eds) Herbal Drugs: Ethnomedicine to Modern Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79116-4_10

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