Abstract
Many studies have shown the functional relevance of cross-modal plasticity in blind men. However, few researches have focused on whether such functional plasticity is associated with macroscopic changes of structural anatomy in brain regions. Fortunately, deformation based morphometry (DBM) provides an important tool for the computational anatomy research. In this study we detected the changes of regional volume in brain structures between the blind men and normal controls with DBM method. Information of the difference is derived from the deformation field acquired during HAMMER non-rigid registration. The experimental results show that the regions expanded in the blind men’s brain are located at Brodmann 19,31 while the contracted regions located at Brodmann 17,18. This research is very helpful to discover the relationship between structural anatomy and functional data of blind men at a macroscopic level from neuroimaging perspective.
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References
N Sadato, A Pascual-Leone, J Grafman, et al. Neural networks for Braille reading by the blind. Brain, 1998, 121:1213–1229.
C Buchel, C Price, R S J Frackowiak, et al. Different activation patterns in the visual cortex of late and congenitally blind subjects. Brain, 1998, 121: 409–419.
L G Cohen, P Celnik, A Pascual-Leone, et al. Functional relevance of cross-modal plasticity in blind humans. Nature, 1997, 389: 180–183.
A Sterr, M Müller, T Elbert, et al. Changed perceptions in Braille readers. Nature, 1998, 391: 134–135.
J. Ashburner, Computational neuroanatomy, PhD Thesis, University of London, England, 2001.
J. Ashburner and K.J. Friston, Voxel-based morphometry—the methods, Neuroimage, 11(6),805–21,2000.
J. Ashburner and K.J. Friston, Why voxel-based morphometry should be used, Neuroimage, 14:1238–43, 2001.
C. Gaser, H.P. Volz, S. Kiebel, S. Riehemann, and H. Sauer, Detecting structural changes in whole brain based on nonlinear deformations—Application to schizophrenia research, NeuroImage, 10: 107–113, 1999.
C. Davatzikos, M. Vaillant, S. Resnick, J. L. Prince, S.I. Letovsky, and R.N. Bryan, A computerized method for morphological analysis of the corpus callosum, J.Compt.Assisted Tomogr, 20: 88–97,1996.
M.K. Chung, K.J. Worsley, T. Paus, C. Cherif, D.L. Collins, J.N. Giedd et al., A unified statistical approach to deformation-based morphometry, NeuroImage, 14(3): 595–606, 2001.
D. Shen and C. Davatzikos, HAMMER: hierarchical attribute matching mechanism for elastic registration, IEEE Trans. Med. Imaging, 21:1421–1439, 2002.
D.W. Shattuck and R.M. Leahy, Graph Based Analysis and Correction of Cortical Volume Topology, IEEE Transactions on Medical Imaging, 20(11):1167–1177, 2001.
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Yang, C., Wu, S., Bai, Y., Gao, H. (2008). Deformation-Based Morphometric study on Blind men’s brain structures. In: Peng, Y., Weng, X. (eds) 7th Asian-Pacific Conference on Medical and Biological Engineering. IFMBE Proceedings, vol 19. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79039-6_55
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DOI: https://doi.org/10.1007/978-3-540-79039-6_55
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-79038-9
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