Abstract
Darier’s Disease
Synonyms
Synonyms for Darier’s disease are keratosis follicularis, Darier’s disease, and dyskeratosis follicularis.
Definition
Darier’s disease is an autosomal−dominant abnormality of keratinization that shows keratotic papules originating from both follicles and interfollicular epidermis. Later, papules appear crusted and verrucous.
Surface Microscopy
After removing dirty brownish keratotic plaques (acantholysis), areas of regularly arranged punctiform papillary capillaries (“naked papillae”) emerge. The papillary dermis has not changed.
Histopathology
Focal suprabasal acantholytic dyskeratosis and lacunae in the slightly acanthotic epidermis as well as hyperkeratosis and patchy parakeratosis are typical signs. Eosinophilic dyskeratotic cells with premature cornification (corps ronds and grains) issue in the epidermis.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
Rights and permissions
Copyright information
© 2008 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
(2008). D. In: Compendium of Surface Microscopic and Dermoscopic Features. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78973-4_4
Download citation
DOI: https://doi.org/10.1007/978-3-540-78973-4_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-78972-7
Online ISBN: 978-3-540-78973-4
eBook Packages: MedicineMedicine (R0)