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Predominantly Antibody Deficiencies

  • Asghar Aghamohmmadi
  • Vassilios Lougaris
  • Alessandro Plebani
  • Toshio Miyawaki
  • Anne Durandy
  • Lennart Hammarström
  • Antibody deficiencies are the most common forms of primary immunodeficiency diseases, generally easily controlled by immunoglobulin substitution.

  • Some of antibody deficiencies could be secondary to a T cell deficiency that has to be intensively looked for, since it severely worsens the prognosis and modifies the treatment.

  • In the absence of early diagnosis and appropriate management, primary antibody deficiency can lead to serious morbidity and early mortality.

  • A diagnostic delay in affected patients with primary antibody deficiency still remains a significant problem due to limited awareness of their presenting features.

  • Clinical history is the most important aspect of suspecting a diagnosis of primary antibody deficiency.

  • Defining the molecular defect of antibody deficiencies is essential for accurate diagnosis, including prenatal diagnosis, and appropriate management of patients.

Keywords

Allergy Clin Immunol Common Variable Immunodeficiency Primary Immunodeficiency Disease Antibody Deficiency Common Variable Immune Deficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2008

Authors and Affiliations

  • Asghar Aghamohmmadi
    • 1
  • Vassilios Lougaris
    • 2
  • Alessandro Plebani
    • 2
  • Toshio Miyawaki
    • 3
  • Anne Durandy
    • 4
  • Lennart Hammarström
    • 5
  1. 1.Division of Allergy and Clinical Immunology Children’s Medical Center HospitalTehran University of Medical SciencesTehranIran
  2. 2.Department of Pediatrics and Institute for Molecular Medicine “A. Nocivelli”University of BresciaBresciaItaly
  3. 3.Department of Pediatrics Faculty of MedicineToyama Medical and Pharmaceutical UniversityToyamaJapan
  4. 4.INSERM U768Hôpital Necker-Enfants MaladesParisFrance
  5. 5.Division of Clinical Immunology Department of Laboratory MedicineKarolinska InstituteStockholmSweden

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